EFEITOS DA INFUSAO CONTINUA DO PROPOFOL SOBRE A FUNCAO RENAL DO CAO. ESTUDO COMPARATIVO COM O PENTOBARBITAL SODICO
Autor(a) principal: | |
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Data de Publicação: | 1994 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.sba.com.br/arquivos/revista/rba/mai94163.pdf http://hdl.handle.net/11449/64450 |
Resumo: | Little research has been done with propofol in relation to renal function. The aim of this study was to evaluate the effects of the continuous infusion of propofol on renal function in dogs. Sixteen dogs, previously anesthetized with pentobarbital sodium (30 mg.kg-1) for surgical preparation, catheterism and monitoring, were studied. The dogs were mechanically ventilated with air and received alcuronium (0.2 mg.kg-1 in bolus and 0.06 mg.kg-1 - maintenance). The following parameters were studied: heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), aortic blood flow (A(o)BF - by electromagnetic flowmeter installed in the ascending aortic), aortic vascular resistance index (A(o)VRI), renal plasma flow (ERPF - by para-aminohipurate clearance), glomerular filtration rate (GFR - by creatinine clearance), effective renal blood flow (ERBF = ERPF/1 - hematocrit), urinary volume (UV), renal vascular resistance (RVR = MAP.80/ERBF.10-3), urinary sodium excretion (UE(Na)), fractionated sodium excretion (FE(Na)), osmolar clearance (C(osm)) and free water clearance (C(H2O)). These parameters were studied at 15 (M1), 30 (M2), 45 (M3) and 60 (M4) min after beginning pentobarbital sodium infusion (5 mg.kg-1.h-1). The dogs were allocated into two groups of eight animals each: G1 (control-pentobarbital sodium) and G2 (propofol). In G1, pentobarbital was given at the four times studied. G2 dogs received the same treatment as G1 dogs at M1 and M2; infusion of pentobarbital was substituted by propofol (3 mg.kg-1 bolus, followed by 12 mg.kg-1.h-1 continuous infusion) at M3 and M4. Profile Analysis was used to analyze the results statistically. In G1 (pentobarbital), there was a significant increase in RVR (M1 < M4) and a decrease in ERPF and ERBF (M1 > M4). In G2 (propofol) there was only a significant increase in A(o)BF (M1 < M2 = M3). In comparison among groups, these was a significant alteration of FE(Na) at M3 (pentobarbital > propofol). It was observed that the continuous infusion of propofol in dogs, at the given doses, did not alter the basic variables of renal function and hemodynamics studied. We concluded that propofol can be one of the drugs of choice to provide base anesthesia in studies of renal function in dogs. |
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EFEITOS DA INFUSAO CONTINUA DO PROPOFOL SOBRE A FUNCAO RENAL DO CAO. ESTUDO COMPARATIVO COM O PENTOBARBITAL SODICOEffects of continuous infusion of propofol on renal function in the dog. Comparative study with pentobarbital sodiumanesthetic technique, general: continuous infusion, venousanesthetic, venous: propofol, pentobarbital sodiumkidney: clearance, functionmonitoring: hemodynamicalcuroniumpentobarbitalpropofolanimal experimentblood flowblood pressurecontrolled studydogglomerulus filtration rateheart ratehemodynamicsintravenous drug administrationkidney functionnonhumansodium excretionurine volumeLittle research has been done with propofol in relation to renal function. The aim of this study was to evaluate the effects of the continuous infusion of propofol on renal function in dogs. Sixteen dogs, previously anesthetized with pentobarbital sodium (30 mg.kg-1) for surgical preparation, catheterism and monitoring, were studied. The dogs were mechanically ventilated with air and received alcuronium (0.2 mg.kg-1 in bolus and 0.06 mg.kg-1 - maintenance). The following parameters were studied: heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), aortic blood flow (A(o)BF - by electromagnetic flowmeter installed in the ascending aortic), aortic vascular resistance index (A(o)VRI), renal plasma flow (ERPF - by para-aminohipurate clearance), glomerular filtration rate (GFR - by creatinine clearance), effective renal blood flow (ERBF = ERPF/1 - hematocrit), urinary volume (UV), renal vascular resistance (RVR = MAP.80/ERBF.10-3), urinary sodium excretion (UE(Na)), fractionated sodium excretion (FE(Na)), osmolar clearance (C(osm)) and free water clearance (C(H2O)). These parameters were studied at 15 (M1), 30 (M2), 45 (M3) and 60 (M4) min after beginning pentobarbital sodium infusion (5 mg.kg-1.h-1). The dogs were allocated into two groups of eight animals each: G1 (control-pentobarbital sodium) and G2 (propofol). In G1, pentobarbital was given at the four times studied. G2 dogs received the same treatment as G1 dogs at M1 and M2; infusion of pentobarbital was substituted by propofol (3 mg.kg-1 bolus, followed by 12 mg.kg-1.h-1 continuous infusion) at M3 and M4. Profile Analysis was used to analyze the results statistically. In G1 (pentobarbital), there was a significant increase in RVR (M1 < M4) and a decrease in ERPF and ERBF (M1 > M4). In G2 (propofol) there was only a significant increase in A(o)BF (M1 < M2 = M3). In comparison among groups, these was a significant alteration of FE(Na) at M3 (pentobarbital > propofol). It was observed that the continuous infusion of propofol in dogs, at the given doses, did not alter the basic variables of renal function and hemodynamics studied. We concluded that propofol can be one of the drugs of choice to provide base anesthesia in studies of renal function in dogs.Departamento de Anestesiologia Faculdado de Medicina UNESP, 18618-000 Rubiao Junior, BotucatuDepartamento de Anestesiologia Faculdado de Medicina UNESP, 18618-000 Rubiao Junior, BotucatuUniversidade Estadual Paulista (Unesp)Do Nascimento, C. [UNESP]Braz, José Reinaldo Cerqueira [UNESP]Curi, P. R. [UNESP]Vane, Luiz Antonio [UNESP]Castiglia, Yara Marcondes Machado [UNESP]2014-05-27T11:17:55Z2014-05-27T11:17:55Z1994-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article163-170application/pdfhttp://www.sba.com.br/arquivos/revista/rba/mai94163.pdfRevista Brasileira de Anestesiologia, v. 44, n. 3, p. 163-170, 1994.0034-7094http://hdl.handle.net/11449/644502-s2.0-00283559252-s2.0-0028355925.pdf7802830125342070Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira de Anestesiologia0.8500,320info:eu-repo/semantics/openAccess2023-09-30T06:07:08Zoai:repositorio.unesp.br:11449/64450Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-09-30T06:07:08Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
EFEITOS DA INFUSAO CONTINUA DO PROPOFOL SOBRE A FUNCAO RENAL DO CAO. ESTUDO COMPARATIVO COM O PENTOBARBITAL SODICO Effects of continuous infusion of propofol on renal function in the dog. Comparative study with pentobarbital sodium |
title |
EFEITOS DA INFUSAO CONTINUA DO PROPOFOL SOBRE A FUNCAO RENAL DO CAO. ESTUDO COMPARATIVO COM O PENTOBARBITAL SODICO |
spellingShingle |
EFEITOS DA INFUSAO CONTINUA DO PROPOFOL SOBRE A FUNCAO RENAL DO CAO. ESTUDO COMPARATIVO COM O PENTOBARBITAL SODICO Do Nascimento, C. [UNESP] anesthetic technique, general: continuous infusion, venous anesthetic, venous: propofol, pentobarbital sodium kidney: clearance, function monitoring: hemodynamic alcuronium pentobarbital propofol animal experiment blood flow blood pressure controlled study dog glomerulus filtration rate heart rate hemodynamics intravenous drug administration kidney function nonhuman sodium excretion urine volume |
title_short |
EFEITOS DA INFUSAO CONTINUA DO PROPOFOL SOBRE A FUNCAO RENAL DO CAO. ESTUDO COMPARATIVO COM O PENTOBARBITAL SODICO |
title_full |
EFEITOS DA INFUSAO CONTINUA DO PROPOFOL SOBRE A FUNCAO RENAL DO CAO. ESTUDO COMPARATIVO COM O PENTOBARBITAL SODICO |
title_fullStr |
EFEITOS DA INFUSAO CONTINUA DO PROPOFOL SOBRE A FUNCAO RENAL DO CAO. ESTUDO COMPARATIVO COM O PENTOBARBITAL SODICO |
title_full_unstemmed |
EFEITOS DA INFUSAO CONTINUA DO PROPOFOL SOBRE A FUNCAO RENAL DO CAO. ESTUDO COMPARATIVO COM O PENTOBARBITAL SODICO |
title_sort |
EFEITOS DA INFUSAO CONTINUA DO PROPOFOL SOBRE A FUNCAO RENAL DO CAO. ESTUDO COMPARATIVO COM O PENTOBARBITAL SODICO |
author |
Do Nascimento, C. [UNESP] |
author_facet |
Do Nascimento, C. [UNESP] Braz, José Reinaldo Cerqueira [UNESP] Curi, P. R. [UNESP] Vane, Luiz Antonio [UNESP] Castiglia, Yara Marcondes Machado [UNESP] |
author_role |
author |
author2 |
Braz, José Reinaldo Cerqueira [UNESP] Curi, P. R. [UNESP] Vane, Luiz Antonio [UNESP] Castiglia, Yara Marcondes Machado [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Do Nascimento, C. [UNESP] Braz, José Reinaldo Cerqueira [UNESP] Curi, P. R. [UNESP] Vane, Luiz Antonio [UNESP] Castiglia, Yara Marcondes Machado [UNESP] |
dc.subject.por.fl_str_mv |
anesthetic technique, general: continuous infusion, venous anesthetic, venous: propofol, pentobarbital sodium kidney: clearance, function monitoring: hemodynamic alcuronium pentobarbital propofol animal experiment blood flow blood pressure controlled study dog glomerulus filtration rate heart rate hemodynamics intravenous drug administration kidney function nonhuman sodium excretion urine volume |
topic |
anesthetic technique, general: continuous infusion, venous anesthetic, venous: propofol, pentobarbital sodium kidney: clearance, function monitoring: hemodynamic alcuronium pentobarbital propofol animal experiment blood flow blood pressure controlled study dog glomerulus filtration rate heart rate hemodynamics intravenous drug administration kidney function nonhuman sodium excretion urine volume |
description |
Little research has been done with propofol in relation to renal function. The aim of this study was to evaluate the effects of the continuous infusion of propofol on renal function in dogs. Sixteen dogs, previously anesthetized with pentobarbital sodium (30 mg.kg-1) for surgical preparation, catheterism and monitoring, were studied. The dogs were mechanically ventilated with air and received alcuronium (0.2 mg.kg-1 in bolus and 0.06 mg.kg-1 - maintenance). The following parameters were studied: heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), aortic blood flow (A(o)BF - by electromagnetic flowmeter installed in the ascending aortic), aortic vascular resistance index (A(o)VRI), renal plasma flow (ERPF - by para-aminohipurate clearance), glomerular filtration rate (GFR - by creatinine clearance), effective renal blood flow (ERBF = ERPF/1 - hematocrit), urinary volume (UV), renal vascular resistance (RVR = MAP.80/ERBF.10-3), urinary sodium excretion (UE(Na)), fractionated sodium excretion (FE(Na)), osmolar clearance (C(osm)) and free water clearance (C(H2O)). These parameters were studied at 15 (M1), 30 (M2), 45 (M3) and 60 (M4) min after beginning pentobarbital sodium infusion (5 mg.kg-1.h-1). The dogs were allocated into two groups of eight animals each: G1 (control-pentobarbital sodium) and G2 (propofol). In G1, pentobarbital was given at the four times studied. G2 dogs received the same treatment as G1 dogs at M1 and M2; infusion of pentobarbital was substituted by propofol (3 mg.kg-1 bolus, followed by 12 mg.kg-1.h-1 continuous infusion) at M3 and M4. Profile Analysis was used to analyze the results statistically. In G1 (pentobarbital), there was a significant increase in RVR (M1 < M4) and a decrease in ERPF and ERBF (M1 > M4). In G2 (propofol) there was only a significant increase in A(o)BF (M1 < M2 = M3). In comparison among groups, these was a significant alteration of FE(Na) at M3 (pentobarbital > propofol). It was observed that the continuous infusion of propofol in dogs, at the given doses, did not alter the basic variables of renal function and hemodynamics studied. We concluded that propofol can be one of the drugs of choice to provide base anesthesia in studies of renal function in dogs. |
publishDate |
1994 |
dc.date.none.fl_str_mv |
1994-01-01 2014-05-27T11:17:55Z 2014-05-27T11:17:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.sba.com.br/arquivos/revista/rba/mai94163.pdf Revista Brasileira de Anestesiologia, v. 44, n. 3, p. 163-170, 1994. 0034-7094 http://hdl.handle.net/11449/64450 2-s2.0-0028355925 2-s2.0-0028355925.pdf 7802830125342070 |
url |
http://www.sba.com.br/arquivos/revista/rba/mai94163.pdf http://hdl.handle.net/11449/64450 |
identifier_str_mv |
Revista Brasileira de Anestesiologia, v. 44, n. 3, p. 163-170, 1994. 0034-7094 2-s2.0-0028355925 2-s2.0-0028355925.pdf 7802830125342070 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Revista Brasileira de Anestesiologia 0.850 0,320 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
163-170 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1797789247063719936 |