Amniotic Fluid-Soluble Form of Triggering Receptors Expressed on Myeloid Cells: A Physiologic Constituent at Term
Main Author: | |
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Publication Date: | 2017 |
Other Authors: | , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.1159/000446943 http://hdl.handle.net/11449/173062 |
Summary: | Background: Triggering receptors expressed on myeloid cells-1 (TREM-1) are innate immune receptors that mediate inflammatory response. In recent times, the role of these receptors has become the focus of several studies in the gestational context. Evaluation of soluble TREM-1 concentration in normal pregnancy is scarce, and no data are available on the levels of this receptor in the last weeks of normal pregnancy. Method: Amniotic fluid (AF) samples were obtained from 77 patients in the last weeks of normal pregnancy during cesarean section, and the soluble form of TREM-1 (sTREM-1) levels determined using specific sandwich enzyme-linked immunosorbent assay kit. Results: sTREM-1 was detectable in all AF samples, and its levels did not vary in the last weeks of third trimester pregnancy. There was no correlation between sTREM-1 levels in AF and advancing gestational age. Conclusion: sTREM-1 is a physiologic constituent of AF and its levels are not temporally regulated in pregnancies at term. |
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Amniotic Fluid-Soluble Form of Triggering Receptors Expressed on Myeloid Cells: A Physiologic Constituent at TermInflammatory responseInnate immunitySoluble receptorsBackground: Triggering receptors expressed on myeloid cells-1 (TREM-1) are innate immune receptors that mediate inflammatory response. In recent times, the role of these receptors has become the focus of several studies in the gestational context. Evaluation of soluble TREM-1 concentration in normal pregnancy is scarce, and no data are available on the levels of this receptor in the last weeks of normal pregnancy. Method: Amniotic fluid (AF) samples were obtained from 77 patients in the last weeks of normal pregnancy during cesarean section, and the soluble form of TREM-1 (sTREM-1) levels determined using specific sandwich enzyme-linked immunosorbent assay kit. Results: sTREM-1 was detectable in all AF samples, and its levels did not vary in the last weeks of third trimester pregnancy. There was no correlation between sTREM-1 levels in AF and advancing gestational age. Conclusion: sTREM-1 is a physiologic constituent of AF and its levels are not temporally regulated in pregnancies at term.Department of Pathology Botucatu Medical School São Paulo State University UNESPDepartment of Dermatology Botucatu Medical School São Paulo State University UNESPDepartment of Obstetrics and Gynecology Jundiaí Medical SchoolBom Jesus HospitalDepartment of Pathology Botucatu Medical School São Paulo State University UNESPDepartment of Dermatology Botucatu Medical School São Paulo State University UNESPUniversidade Estadual Paulista (Unesp)Jundiaí Medical SchoolUniversidade Estadual de Maringá (UEM)Moço, Natália Prearo [UNESP]Martin, Laura Fernandes [UNESP]De Andrade Ramos, Bruna Ribeiro [UNESP]De Camargo, Rodrigo Paupério SoaresSarmento, Stephanno Gomes PereiraFernandes, Karayna GilFilho, Dionísio ChiarattoMiot, Hélio Amante [UNESP]Da Silva, Márcia Guimarães [UNESP]2018-12-11T17:03:20Z2018-12-11T17:03:20Z2017-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article131-136http://dx.doi.org/10.1159/000446943Gynecologic and Obstetric Investigation, v. 82, n. 2, p. 131-136, 2017.1423-002X0378-7346http://hdl.handle.net/11449/17306210.1159/0004469432-s2.0-84973526779Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGynecologic and Obstetric Investigation0,545info:eu-repo/semantics/openAccess2021-10-23T16:22:28Zoai:repositorio.unesp.br:11449/173062Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T16:22:28Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Amniotic Fluid-Soluble Form of Triggering Receptors Expressed on Myeloid Cells: A Physiologic Constituent at Term |
title |
Amniotic Fluid-Soluble Form of Triggering Receptors Expressed on Myeloid Cells: A Physiologic Constituent at Term |
spellingShingle |
Amniotic Fluid-Soluble Form of Triggering Receptors Expressed on Myeloid Cells: A Physiologic Constituent at Term Moço, Natália Prearo [UNESP] Inflammatory response Innate immunity Soluble receptors |
title_short |
Amniotic Fluid-Soluble Form of Triggering Receptors Expressed on Myeloid Cells: A Physiologic Constituent at Term |
title_full |
Amniotic Fluid-Soluble Form of Triggering Receptors Expressed on Myeloid Cells: A Physiologic Constituent at Term |
title_fullStr |
Amniotic Fluid-Soluble Form of Triggering Receptors Expressed on Myeloid Cells: A Physiologic Constituent at Term |
title_full_unstemmed |
Amniotic Fluid-Soluble Form of Triggering Receptors Expressed on Myeloid Cells: A Physiologic Constituent at Term |
title_sort |
Amniotic Fluid-Soluble Form of Triggering Receptors Expressed on Myeloid Cells: A Physiologic Constituent at Term |
author |
Moço, Natália Prearo [UNESP] |
author_facet |
Moço, Natália Prearo [UNESP] Martin, Laura Fernandes [UNESP] De Andrade Ramos, Bruna Ribeiro [UNESP] De Camargo, Rodrigo Paupério Soares Sarmento, Stephanno Gomes Pereira Fernandes, Karayna Gil Filho, Dionísio Chiaratto Miot, Hélio Amante [UNESP] Da Silva, Márcia Guimarães [UNESP] |
author_role |
author |
author2 |
Martin, Laura Fernandes [UNESP] De Andrade Ramos, Bruna Ribeiro [UNESP] De Camargo, Rodrigo Paupério Soares Sarmento, Stephanno Gomes Pereira Fernandes, Karayna Gil Filho, Dionísio Chiaratto Miot, Hélio Amante [UNESP] Da Silva, Márcia Guimarães [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Jundiaí Medical School Universidade Estadual de Maringá (UEM) |
dc.contributor.author.fl_str_mv |
Moço, Natália Prearo [UNESP] Martin, Laura Fernandes [UNESP] De Andrade Ramos, Bruna Ribeiro [UNESP] De Camargo, Rodrigo Paupério Soares Sarmento, Stephanno Gomes Pereira Fernandes, Karayna Gil Filho, Dionísio Chiaratto Miot, Hélio Amante [UNESP] Da Silva, Márcia Guimarães [UNESP] |
dc.subject.por.fl_str_mv |
Inflammatory response Innate immunity Soluble receptors |
topic |
Inflammatory response Innate immunity Soluble receptors |
description |
Background: Triggering receptors expressed on myeloid cells-1 (TREM-1) are innate immune receptors that mediate inflammatory response. In recent times, the role of these receptors has become the focus of several studies in the gestational context. Evaluation of soluble TREM-1 concentration in normal pregnancy is scarce, and no data are available on the levels of this receptor in the last weeks of normal pregnancy. Method: Amniotic fluid (AF) samples were obtained from 77 patients in the last weeks of normal pregnancy during cesarean section, and the soluble form of TREM-1 (sTREM-1) levels determined using specific sandwich enzyme-linked immunosorbent assay kit. Results: sTREM-1 was detectable in all AF samples, and its levels did not vary in the last weeks of third trimester pregnancy. There was no correlation between sTREM-1 levels in AF and advancing gestational age. Conclusion: sTREM-1 is a physiologic constituent of AF and its levels are not temporally regulated in pregnancies at term. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03-01 2018-12-11T17:03:20Z 2018-12-11T17:03:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1159/000446943 Gynecologic and Obstetric Investigation, v. 82, n. 2, p. 131-136, 2017. 1423-002X 0378-7346 http://hdl.handle.net/11449/173062 10.1159/000446943 2-s2.0-84973526779 |
url |
http://dx.doi.org/10.1159/000446943 http://hdl.handle.net/11449/173062 |
identifier_str_mv |
Gynecologic and Obstetric Investigation, v. 82, n. 2, p. 131-136, 2017. 1423-002X 0378-7346 10.1159/000446943 2-s2.0-84973526779 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Gynecologic and Obstetric Investigation 0,545 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
131-136 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1797789963392122880 |