Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2014/230129 http://hdl.handle.net/11449/117230 |
Resumo: | In visceral leishmaniasis (VL) endemic areas, a minority of infected individuals progress to disease since most of them develop protective immunity. Therefore, we investigated the risk markers of VL within nonimmune sector. Analyzing infected symptomatic and, asymptomatic, and noninfected individuals, VL patients presented with reduced high-density lipoprotein cholesterol (HDL-C), elevated triacylglycerol (TAG), and elevated very-low-density lipoprotein cholesterol (VLDL-C) levels. A polymorphism analysis of the lipoprotein lipase (LPL) gene using HindIII restriction digestion (N = 156 samples) (H+ = the presence and H = the absence of mutation) revealed an increased adjusted odds ratio (OR) of VL versus noninfected individuals when the H+/H+ was compared with the H-/H-genotype (OR = 21.3; 95% CI = 2.32-3335.3; P = 0.003). The H+/H+ genotype and the H+ allele were associated with elevated VLDL-C and TAG levels (P < 0.05) and reduced HDL-C levels (P < 0.05). An analysis of the L162V polymorphism in the peroxisome proliferator-activated receptor alpha (PPAR alpha) gene (n = 248) revealed an increased adjusted OR when the Leu/Val was compared with the Leu/Leu genotype (OR = 8.77; 95% CI = 1.41-78.70; P = 0.014). High TAG (P = 0.021) and VLDL-C (P = 0.023) levels were associated with susceptibility to VL, whereas low HDL (P = 0.006) levels with resistance to infection. The mutated LPL and the PPAR alpha Leu/Val genotypes may be considered risk markers for the development of VL. |
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Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantumIn visceral leishmaniasis (VL) endemic areas, a minority of infected individuals progress to disease since most of them develop protective immunity. Therefore, we investigated the risk markers of VL within nonimmune sector. Analyzing infected symptomatic and, asymptomatic, and noninfected individuals, VL patients presented with reduced high-density lipoprotein cholesterol (HDL-C), elevated triacylglycerol (TAG), and elevated very-low-density lipoprotein cholesterol (VLDL-C) levels. A polymorphism analysis of the lipoprotein lipase (LPL) gene using HindIII restriction digestion (N = 156 samples) (H+ = the presence and H = the absence of mutation) revealed an increased adjusted odds ratio (OR) of VL versus noninfected individuals when the H+/H+ was compared with the H-/H-genotype (OR = 21.3; 95% CI = 2.32-3335.3; P = 0.003). The H+/H+ genotype and the H+ allele were associated with elevated VLDL-C and TAG levels (P < 0.05) and reduced HDL-C levels (P < 0.05). An analysis of the L162V polymorphism in the peroxisome proliferator-activated receptor alpha (PPAR alpha) gene (n = 248) revealed an increased adjusted OR when the Leu/Val was compared with the Leu/Leu genotype (OR = 8.77; 95% CI = 1.41-78.70; P = 0.014). High TAG (P = 0.021) and VLDL-C (P = 0.023) levels were associated with susceptibility to VL, whereas low HDL (P = 0.006) levels with resistance to infection. The mutated LPL and the PPAR alpha Leu/Val genotypes may be considered risk markers for the development of VL.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Laboratorio de Investigacao MedicaUniv Sao Paulo, Inst Med Trop Sao Paulo, Lab Soroepidemiol & Imunobiol, BR-05403000 Sao Paulo, BrazilUniv Estadual Paulista, Inst Biociencias, Dept Parasitol, BR-18618970 Botucatu, SP, BrazilUniv Fed Piaui, Inst Doencas Trop Natan Portella, BR-64001450 Teresina, PI, BrazilUniv Estado Rio de Janeiro, Inst Social Med, Dept Epidemiol, BR-20550900 Rio De Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, Inst Estudos Saude Colet, BR-21941598 Rio De Janeiro, RJ, BrazilUniv Sao Paulo, Fac Med, Dept Prevent Med, BR-01246903 Rio De Janeiro, RJ, BrazilUniv Estadual Paulista, Inst Biociencias, Dept Parasitol, BR-18618970 Botucatu, SP, BrazilCNPq: 154581/2006-2FAPESP: 06/60006-9Laboratorio de Investigacao MedicaLIM/38 HC-FMUSPHindawi Publishing CorporationUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Univ Fed PiauiUniversidade do Estado do Rio de Janeiro (UERJ)Universidade Federal do Rio de Janeiro (UFRJ)Teixeira Carvalho, Marcia DiasAlonso, Diego Peres [UNESP]Vieira Vendrame, Celia MariaCosta, Dorcas LamounierNery Costa, Carlos HenriqueWerneck, Guilherme LoureiroMartins Ribolla, Paulo Eduardo [UNESP]Goto, Hiro2015-03-18T15:55:35Z2015-03-18T15:55:35Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/epub+zipapplication/pdfhttp://dx.doi.org/10.1155/2014/230129Mediators Of Inflammation. New York: Hindawi Publishing Corporation, 10 p., 2014.0962-9351http://hdl.handle.net/11449/11723010.1155/2014/230129WOS:000342939400001WOS000342939400001.pdfWOS000342939400001.epub3577149748456880Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMediators Of Inflammation3.5491,370info:eu-repo/semantics/openAccess2024-01-21T06:21:41Zoai:repositorio.unesp.br:11449/117230Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-21T06:21:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum |
title |
Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum |
spellingShingle |
Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum Teixeira Carvalho, Marcia Dias |
title_short |
Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum |
title_full |
Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum |
title_fullStr |
Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum |
title_full_unstemmed |
Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum |
title_sort |
Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum |
author |
Teixeira Carvalho, Marcia Dias |
author_facet |
Teixeira Carvalho, Marcia Dias Alonso, Diego Peres [UNESP] Vieira Vendrame, Celia Maria Costa, Dorcas Lamounier Nery Costa, Carlos Henrique Werneck, Guilherme Loureiro Martins Ribolla, Paulo Eduardo [UNESP] Goto, Hiro |
author_role |
author |
author2 |
Alonso, Diego Peres [UNESP] Vieira Vendrame, Celia Maria Costa, Dorcas Lamounier Nery Costa, Carlos Henrique Werneck, Guilherme Loureiro Martins Ribolla, Paulo Eduardo [UNESP] Goto, Hiro |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) Univ Fed Piaui Universidade do Estado do Rio de Janeiro (UERJ) Universidade Federal do Rio de Janeiro (UFRJ) |
dc.contributor.author.fl_str_mv |
Teixeira Carvalho, Marcia Dias Alonso, Diego Peres [UNESP] Vieira Vendrame, Celia Maria Costa, Dorcas Lamounier Nery Costa, Carlos Henrique Werneck, Guilherme Loureiro Martins Ribolla, Paulo Eduardo [UNESP] Goto, Hiro |
description |
In visceral leishmaniasis (VL) endemic areas, a minority of infected individuals progress to disease since most of them develop protective immunity. Therefore, we investigated the risk markers of VL within nonimmune sector. Analyzing infected symptomatic and, asymptomatic, and noninfected individuals, VL patients presented with reduced high-density lipoprotein cholesterol (HDL-C), elevated triacylglycerol (TAG), and elevated very-low-density lipoprotein cholesterol (VLDL-C) levels. A polymorphism analysis of the lipoprotein lipase (LPL) gene using HindIII restriction digestion (N = 156 samples) (H+ = the presence and H = the absence of mutation) revealed an increased adjusted odds ratio (OR) of VL versus noninfected individuals when the H+/H+ was compared with the H-/H-genotype (OR = 21.3; 95% CI = 2.32-3335.3; P = 0.003). The H+/H+ genotype and the H+ allele were associated with elevated VLDL-C and TAG levels (P < 0.05) and reduced HDL-C levels (P < 0.05). An analysis of the L162V polymorphism in the peroxisome proliferator-activated receptor alpha (PPAR alpha) gene (n = 248) revealed an increased adjusted OR when the Leu/Val was compared with the Leu/Leu genotype (OR = 8.77; 95% CI = 1.41-78.70; P = 0.014). High TAG (P = 0.021) and VLDL-C (P = 0.023) levels were associated with susceptibility to VL, whereas low HDL (P = 0.006) levels with resistance to infection. The mutated LPL and the PPAR alpha Leu/Val genotypes may be considered risk markers for the development of VL. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-01 2015-03-18T15:55:35Z 2015-03-18T15:55:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2014/230129 Mediators Of Inflammation. New York: Hindawi Publishing Corporation, 10 p., 2014. 0962-9351 http://hdl.handle.net/11449/117230 10.1155/2014/230129 WOS:000342939400001 WOS000342939400001.pdf WOS000342939400001.epub 3577149748456880 |
url |
http://dx.doi.org/10.1155/2014/230129 http://hdl.handle.net/11449/117230 |
identifier_str_mv |
Mediators Of Inflammation. New York: Hindawi Publishing Corporation, 10 p., 2014. 0962-9351 10.1155/2014/230129 WOS:000342939400001 WOS000342939400001.pdf WOS000342939400001.epub 3577149748456880 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mediators Of Inflammation 3.549 1,370 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
10 application/epub+zip application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797790355019530240 |