Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer

Detalhes bibliográficos
Autor(a) principal: Gomes, Paulo C. [UNESP]
Data de Publicação: 2011
Outros Autores: de Souza, Bibiana M. [UNESP], Dias, Nathalia B. [UNESP], Cesar-Tognoli, Lilian M. M. [UNESP], Silva-Filho, Luiz C. [UNESP], Tormena, Claudio F., Rittner, Roberto, Richardson, Michael, Cordeiro, Marta N., Palma, Mario Sergio [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.toxicon.2010.11.021
http://hdl.handle.net/11449/19670
Resumo: Nigriventrine was isolated from the armed spider Phoneutria nigriventer, in which it constitutes about 0.4% of the total venom content. Its structure was determined to be [1,1`-(1-hydroxyhydrazine-1,2-diyl)bis(oxy)bis(4-hydroxy-2,6-dioxopiperidine-4 carboxylic acid)] by NMR, HR-ES/IMS and MS/MS methods. The intracerebroventricular application of nigriventrine in rat brain, followed by the detection of c-Fos protein expression, indicated that the compound was neuroactive in the motor cortex, sensory cortex, piriform cortex, median preoptic nucleus, dorsal endopiriform nucleus, lateral septal nucleus and hippocampus of rat brain. Nigriventrine causes convulsions in rats, even when peripherally applied. (c) 2010 Elsevier Ltd. All rights reserved.
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spelling Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventerSpider venomSpectroscopyLow molecular massNeurotoxinGlutamate receptorNatural productNigriventrine was isolated from the armed spider Phoneutria nigriventer, in which it constitutes about 0.4% of the total venom content. Its structure was determined to be [1,1`-(1-hydroxyhydrazine-1,2-diyl)bis(oxy)bis(4-hydroxy-2,6-dioxopiperidine-4 carboxylic acid)] by NMR, HR-ES/IMS and MS/MS methods. The intracerebroventricular application of nigriventrine in rat brain, followed by the detection of c-Fos protein expression, indicated that the compound was neuroactive in the motor cortex, sensory cortex, piriform cortex, median preoptic nucleus, dorsal endopiriform nucleus, lateral septal nucleus and hippocampus of rat brain. Nigriventrine causes convulsions in rats, even when peripherally applied. (c) 2010 Elsevier Ltd. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)INCT-ImunologiaSão Paulo State Univ UNESP, Dept Biol CEIS, Inst Biosci, São Paulo, BrazilSão Paulo State Univ UNESP, Dept Chem, Fac Sci, São Paulo, BrazilUniv Estadual Campinas, Inst Chem, São Paulo, BrazilEzequiel Dias Fdn FUNED, Ctr Res & Dev, Belo Horizonte, MG, BrazilSão Paulo State Univ UNESP, Dept Biol CEIS, Inst Biosci, São Paulo, BrazilSão Paulo State Univ UNESP, Dept Chem, Fac Sci, São Paulo, BrazilFAPESP: 04/07942-2FAPESP: 06/57122-6CNPq: 472870/2004-1Pergamon-Elsevier B.V. LtdUniversidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Fundação Ezequiel Dias (FUNED)Gomes, Paulo C. [UNESP]de Souza, Bibiana M. [UNESP]Dias, Nathalia B. [UNESP]Cesar-Tognoli, Lilian M. M. [UNESP]Silva-Filho, Luiz C. [UNESP]Tormena, Claudio F.Rittner, RobertoRichardson, MichaelCordeiro, Marta N.Palma, Mario Sergio [UNESP]2014-05-20T13:54:59Z2014-05-20T13:54:59Z2011-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article266-274application/pdfhttp://dx.doi.org/10.1016/j.toxicon.2010.11.021Toxicon. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 2, p. 266-274, 2011.0041-0101http://hdl.handle.net/11449/1967010.1016/j.toxicon.2010.11.021WOS:000287629400010WOS000287629400010.pdf2901888624506535Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengToxicon2.3520,692info:eu-repo/semantics/openAccess2024-04-11T14:57:10Zoai:repositorio.unesp.br:11449/19670Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-11T14:57:10Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer
title Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer
spellingShingle Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer
Gomes, Paulo C. [UNESP]
Spider venom
Spectroscopy
Low molecular mass
Neurotoxin
Glutamate receptor
Natural product
title_short Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer
title_full Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer
title_fullStr Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer
title_full_unstemmed Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer
title_sort Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer
author Gomes, Paulo C. [UNESP]
author_facet Gomes, Paulo C. [UNESP]
de Souza, Bibiana M. [UNESP]
Dias, Nathalia B. [UNESP]
Cesar-Tognoli, Lilian M. M. [UNESP]
Silva-Filho, Luiz C. [UNESP]
Tormena, Claudio F.
Rittner, Roberto
Richardson, Michael
Cordeiro, Marta N.
Palma, Mario Sergio [UNESP]
author_role author
author2 de Souza, Bibiana M. [UNESP]
Dias, Nathalia B. [UNESP]
Cesar-Tognoli, Lilian M. M. [UNESP]
Silva-Filho, Luiz C. [UNESP]
Tormena, Claudio F.
Rittner, Roberto
Richardson, Michael
Cordeiro, Marta N.
Palma, Mario Sergio [UNESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Estadual de Campinas (UNICAMP)
Fundação Ezequiel Dias (FUNED)
dc.contributor.author.fl_str_mv Gomes, Paulo C. [UNESP]
de Souza, Bibiana M. [UNESP]
Dias, Nathalia B. [UNESP]
Cesar-Tognoli, Lilian M. M. [UNESP]
Silva-Filho, Luiz C. [UNESP]
Tormena, Claudio F.
Rittner, Roberto
Richardson, Michael
Cordeiro, Marta N.
Palma, Mario Sergio [UNESP]
dc.subject.por.fl_str_mv Spider venom
Spectroscopy
Low molecular mass
Neurotoxin
Glutamate receptor
Natural product
topic Spider venom
Spectroscopy
Low molecular mass
Neurotoxin
Glutamate receptor
Natural product
description Nigriventrine was isolated from the armed spider Phoneutria nigriventer, in which it constitutes about 0.4% of the total venom content. Its structure was determined to be [1,1`-(1-hydroxyhydrazine-1,2-diyl)bis(oxy)bis(4-hydroxy-2,6-dioxopiperidine-4 carboxylic acid)] by NMR, HR-ES/IMS and MS/MS methods. The intracerebroventricular application of nigriventrine in rat brain, followed by the detection of c-Fos protein expression, indicated that the compound was neuroactive in the motor cortex, sensory cortex, piriform cortex, median preoptic nucleus, dorsal endopiriform nucleus, lateral septal nucleus and hippocampus of rat brain. Nigriventrine causes convulsions in rats, even when peripherally applied. (c) 2010 Elsevier Ltd. All rights reserved.
publishDate 2011
dc.date.none.fl_str_mv 2011-02-01
2014-05-20T13:54:59Z
2014-05-20T13:54:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.toxicon.2010.11.021
Toxicon. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 2, p. 266-274, 2011.
0041-0101
http://hdl.handle.net/11449/19670
10.1016/j.toxicon.2010.11.021
WOS:000287629400010
WOS000287629400010.pdf
2901888624506535
url http://dx.doi.org/10.1016/j.toxicon.2010.11.021
http://hdl.handle.net/11449/19670
identifier_str_mv Toxicon. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 2, p. 266-274, 2011.
0041-0101
10.1016/j.toxicon.2010.11.021
WOS:000287629400010
WOS000287629400010.pdf
2901888624506535
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Toxicon
2.352
0,692
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 266-274
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier B.V. Ltd
publisher.none.fl_str_mv Pergamon-Elsevier B.V. Ltd
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799964781589823488

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