Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/j.1365-3024.2009.01160.x http://hdl.handle.net/11449/18249 |
Resumo: | P>In this study, we investigated the characteristics of the infection and subsequent immunity induced by Strongyloides venezuelensis in Lewis rats. Animals were infected with 4000 L3 of S. venezuelensis and number of eggs per gram of faeces indicated an acute phase around day 8 and a recovery phase around day 32 after infection. A strong Th2 polarization during recovery phase was ascertained by a significant increase in IgG1 and IgE compared with that in the acute period. A shift in the cytokine profile confirmed these findings. A predominant production of IFN-gamma during the acute phase was followed by IL-10 production during recovery. Together these findings show that experimental infection of Lewis rats with S. venezuelensis presents a kinetics of parasite establishment and immunity similar to that described in other models of helminthic infection. |
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Repositório Institucional da UNESP |
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Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 responseLewis ratsStrongyloides venezuelensisTh2 cellsP>In this study, we investigated the characteristics of the infection and subsequent immunity induced by Strongyloides venezuelensis in Lewis rats. Animals were infected with 4000 L3 of S. venezuelensis and number of eggs per gram of faeces indicated an acute phase around day 8 and a recovery phase around day 32 after infection. A strong Th2 polarization during recovery phase was ascertained by a significant increase in IgG1 and IgE compared with that in the acute period. A shift in the cytokine profile confirmed these findings. A predominant production of IFN-gamma during the acute phase was followed by IL-10 production during recovery. Together these findings show that experimental infection of Lewis rats with S. venezuelensis presents a kinetics of parasite establishment and immunity similar to that described in other models of helminthic infection.São Paulo State Univ UNESP, Biosci Inst, Dept Microbiol & Immunol, São Paulo, BrazilSão Paulo State Univ UNESP, Biosci Inst, Dept Parasitol, São Paulo, BrazilSão Paulo State Univ UNESP, Biosci Inst, Dept Microbiol & Immunol, São Paulo, BrazilSão Paulo State Univ UNESP, Biosci Inst, Dept Parasitol, São Paulo, BrazilWiley-Blackwell Publishing, IncUniversidade Estadual Paulista (Unesp)Chiuso-Minicucci, F. [UNESP]Marra, N. M. [UNESP]Zorzella-Pezavento, S. F. G. [UNESP]Franca, T. G. D. [UNESP]Ishikawa, L. L. W. [UNESP]Amarante, M. R. V. [UNESP]Amarante, Alessandro Francisco Talamini do [UNESP]Sartori, Alexandrina [UNESP]2014-05-20T13:51:06Z2014-05-20T13:51:06Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article74-78http://dx.doi.org/10.1111/j.1365-3024.2009.01160.xParasite Immunology. Malden: Wiley-blackwell Publishing, Inc, v. 32, n. 1, p. 74-78, 2010.0141-9838http://hdl.handle.net/11449/1824910.1111/j.1365-3024.2009.01160.xWOS:000272661500008267723166332970649775724161295270000-0002-5929-1223Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengParasite Immunology2.8361,173info:eu-repo/semantics/openAccess2021-10-23T15:25:15Zoai:repositorio.unesp.br:11449/18249Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T15:25:15Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response |
title |
Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response |
spellingShingle |
Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response Chiuso-Minicucci, F. [UNESP] Lewis rats Strongyloides venezuelensis Th2 cells |
title_short |
Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response |
title_full |
Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response |
title_fullStr |
Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response |
title_full_unstemmed |
Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response |
title_sort |
Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response |
author |
Chiuso-Minicucci, F. [UNESP] |
author_facet |
Chiuso-Minicucci, F. [UNESP] Marra, N. M. [UNESP] Zorzella-Pezavento, S. F. G. [UNESP] Franca, T. G. D. [UNESP] Ishikawa, L. L. W. [UNESP] Amarante, M. R. V. [UNESP] Amarante, Alessandro Francisco Talamini do [UNESP] Sartori, Alexandrina [UNESP] |
author_role |
author |
author2 |
Marra, N. M. [UNESP] Zorzella-Pezavento, S. F. G. [UNESP] Franca, T. G. D. [UNESP] Ishikawa, L. L. W. [UNESP] Amarante, M. R. V. [UNESP] Amarante, Alessandro Francisco Talamini do [UNESP] Sartori, Alexandrina [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Chiuso-Minicucci, F. [UNESP] Marra, N. M. [UNESP] Zorzella-Pezavento, S. F. G. [UNESP] Franca, T. G. D. [UNESP] Ishikawa, L. L. W. [UNESP] Amarante, M. R. V. [UNESP] Amarante, Alessandro Francisco Talamini do [UNESP] Sartori, Alexandrina [UNESP] |
dc.subject.por.fl_str_mv |
Lewis rats Strongyloides venezuelensis Th2 cells |
topic |
Lewis rats Strongyloides venezuelensis Th2 cells |
description |
P>In this study, we investigated the characteristics of the infection and subsequent immunity induced by Strongyloides venezuelensis in Lewis rats. Animals were infected with 4000 L3 of S. venezuelensis and number of eggs per gram of faeces indicated an acute phase around day 8 and a recovery phase around day 32 after infection. A strong Th2 polarization during recovery phase was ascertained by a significant increase in IgG1 and IgE compared with that in the acute period. A shift in the cytokine profile confirmed these findings. A predominant production of IFN-gamma during the acute phase was followed by IL-10 production during recovery. Together these findings show that experimental infection of Lewis rats with S. venezuelensis presents a kinetics of parasite establishment and immunity similar to that described in other models of helminthic infection. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 2014-05-20T13:51:06Z 2014-05-20T13:51:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/j.1365-3024.2009.01160.x Parasite Immunology. Malden: Wiley-blackwell Publishing, Inc, v. 32, n. 1, p. 74-78, 2010. 0141-9838 http://hdl.handle.net/11449/18249 10.1111/j.1365-3024.2009.01160.x WOS:000272661500008 2677231663329706 4977572416129527 0000-0002-5929-1223 |
url |
http://dx.doi.org/10.1111/j.1365-3024.2009.01160.x http://hdl.handle.net/11449/18249 |
identifier_str_mv |
Parasite Immunology. Malden: Wiley-blackwell Publishing, Inc, v. 32, n. 1, p. 74-78, 2010. 0141-9838 10.1111/j.1365-3024.2009.01160.x WOS:000272661500008 2677231663329706 4977572416129527 0000-0002-5929-1223 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Parasite Immunology 2.836 1,173 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
74-78 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell Publishing, Inc |
publisher.none.fl_str_mv |
Wiley-Blackwell Publishing, Inc |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789345580580864 |