Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.ncbi.nlm.nih.gov/pubmed/22739724 http://hdl.handle.net/11449/11418 |
Resumo: | Background: The objective of this study was to determine the early echocardiographic predictors of elevated left ventricular end-diastolic pressure (LVEDP) after a long follow-up period in the infarcted rat model.Material/Methods: Five days and three months after surgery, sham and infarcted animals were subjected to transthoracic echocardiography. Regression analysis and receiver-operating characteristic (ROC) curve were performed for predicting increased LVEDP 3 months after MI.Results: Among all of the variables, assessed 5 days after myocardial infarction, infarct size (OR: 0.760; CI 95% 0.563-0.900; p=0.005), end-systolic area (ESA) (OR: 0.761; Cl 95% 0.564-0.900; p=0.008), fractional area change (FAC) (OR: 0.771; CI 95% 0.574-0.907; p=0.003), and posterior wall-shortening velocity (PWSV) (OR: 0.703; CI 95% 0.502-0.860; p=0.048) were predictors of increased LVEDP. The LVEDP was 3.6 +/- 1.8 mmHg in the control group and 9.4 +/- 7.8 mmHg among the infarcted animals (p=0.007). Considering the critical value of predictor variables in inducing cardiac dysfunction, the cut-off value was 35% for infarct size, 0.33 cm(2) for ESA, 40% for FAC, and 26 mm/s for PWSV.Conclusions: Infarct size, FAC, ESA, and PWSV, assessed five days after myocardial infarction, can be used to estimate an increased LVEDP three months following the coronary occlusion. |
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Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in ratsheart failurecardiac functionremodelingBackground: The objective of this study was to determine the early echocardiographic predictors of elevated left ventricular end-diastolic pressure (LVEDP) after a long follow-up period in the infarcted rat model.Material/Methods: Five days and three months after surgery, sham and infarcted animals were subjected to transthoracic echocardiography. Regression analysis and receiver-operating characteristic (ROC) curve were performed for predicting increased LVEDP 3 months after MI.Results: Among all of the variables, assessed 5 days after myocardial infarction, infarct size (OR: 0.760; CI 95% 0.563-0.900; p=0.005), end-systolic area (ESA) (OR: 0.761; Cl 95% 0.564-0.900; p=0.008), fractional area change (FAC) (OR: 0.771; CI 95% 0.574-0.907; p=0.003), and posterior wall-shortening velocity (PWSV) (OR: 0.703; CI 95% 0.502-0.860; p=0.048) were predictors of increased LVEDP. The LVEDP was 3.6 +/- 1.8 mmHg in the control group and 9.4 +/- 7.8 mmHg among the infarcted animals (p=0.007). Considering the critical value of predictor variables in inducing cardiac dysfunction, the cut-off value was 35% for infarct size, 0.33 cm(2) for ESA, 40% for FAC, and 26 mm/s for PWSV.Conclusions: Infarct size, FAC, ESA, and PWSV, assessed five days after myocardial infarction, can be used to estimate an increased LVEDP three months following the coronary occlusion.Botucatu Medical SchoolUNESP, Botucatu Med Sch, Dept Internal Med, BR-18618970 Botucatu, SP, BrazilUNESP, Botucatu Med Sch, Dept Internal Med, BR-18618970 Botucatu, SP, BrazilInt Scientific Literature, IncUniversidade Estadual Paulista (Unesp)Gaiolla, Paula Schmidt Azevedo [UNESP]Polegato, Bertha Furlan [UNESP]Minicucci, Marcos Ferreira [UNESP]Pio, Stephan M. [UNESP]Silva, Igor A. [UNESP]Santos, Priscila P. [UNESP]Okoshi, Katashi [UNESP]Paiva, Sergio Alberto Rupp de [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]2014-05-20T13:33:21Z2014-05-20T13:33:21Z2012-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBR253-BR258http://www.ncbi.nlm.nih.gov/pubmed/22739724Medical Science Monitor. Smithtown: Int Scientific Literature, Inc, v. 18, n. 7, p. BR253-BR258, 2012.1234-1010http://hdl.handle.net/11449/11418WOS:00030688330000415909715763094205016839015394547121314080140264774387040344716730000-0002-5843-6232Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedical Science Monitor0,619info:eu-repo/semantics/openAccess2021-10-23T20:18:04Zoai:repositorio.unesp.br:11449/11418Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T20:18:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats |
title |
Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats |
spellingShingle |
Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats Gaiolla, Paula Schmidt Azevedo [UNESP] heart failure cardiac function remodeling |
title_short |
Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats |
title_full |
Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats |
title_fullStr |
Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats |
title_full_unstemmed |
Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats |
title_sort |
Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats |
author |
Gaiolla, Paula Schmidt Azevedo [UNESP] |
author_facet |
Gaiolla, Paula Schmidt Azevedo [UNESP] Polegato, Bertha Furlan [UNESP] Minicucci, Marcos Ferreira [UNESP] Pio, Stephan M. [UNESP] Silva, Igor A. [UNESP] Santos, Priscila P. [UNESP] Okoshi, Katashi [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] |
author_role |
author |
author2 |
Polegato, Bertha Furlan [UNESP] Minicucci, Marcos Ferreira [UNESP] Pio, Stephan M. [UNESP] Silva, Igor A. [UNESP] Santos, Priscila P. [UNESP] Okoshi, Katashi [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Gaiolla, Paula Schmidt Azevedo [UNESP] Polegato, Bertha Furlan [UNESP] Minicucci, Marcos Ferreira [UNESP] Pio, Stephan M. [UNESP] Silva, Igor A. [UNESP] Santos, Priscila P. [UNESP] Okoshi, Katashi [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] |
dc.subject.por.fl_str_mv |
heart failure cardiac function remodeling |
topic |
heart failure cardiac function remodeling |
description |
Background: The objective of this study was to determine the early echocardiographic predictors of elevated left ventricular end-diastolic pressure (LVEDP) after a long follow-up period in the infarcted rat model.Material/Methods: Five days and three months after surgery, sham and infarcted animals were subjected to transthoracic echocardiography. Regression analysis and receiver-operating characteristic (ROC) curve were performed for predicting increased LVEDP 3 months after MI.Results: Among all of the variables, assessed 5 days after myocardial infarction, infarct size (OR: 0.760; CI 95% 0.563-0.900; p=0.005), end-systolic area (ESA) (OR: 0.761; Cl 95% 0.564-0.900; p=0.008), fractional area change (FAC) (OR: 0.771; CI 95% 0.574-0.907; p=0.003), and posterior wall-shortening velocity (PWSV) (OR: 0.703; CI 95% 0.502-0.860; p=0.048) were predictors of increased LVEDP. The LVEDP was 3.6 +/- 1.8 mmHg in the control group and 9.4 +/- 7.8 mmHg among the infarcted animals (p=0.007). Considering the critical value of predictor variables in inducing cardiac dysfunction, the cut-off value was 35% for infarct size, 0.33 cm(2) for ESA, 40% for FAC, and 26 mm/s for PWSV.Conclusions: Infarct size, FAC, ESA, and PWSV, assessed five days after myocardial infarction, can be used to estimate an increased LVEDP three months following the coronary occlusion. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-07-01 2014-05-20T13:33:21Z 2014-05-20T13:33:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.ncbi.nlm.nih.gov/pubmed/22739724 Medical Science Monitor. Smithtown: Int Scientific Literature, Inc, v. 18, n. 7, p. BR253-BR258, 2012. 1234-1010 http://hdl.handle.net/11449/11418 WOS:000306883300004 1590971576309420 5016839015394547 1213140801402647 7438704034471673 0000-0002-5843-6232 |
url |
http://www.ncbi.nlm.nih.gov/pubmed/22739724 http://hdl.handle.net/11449/11418 |
identifier_str_mv |
Medical Science Monitor. Smithtown: Int Scientific Literature, Inc, v. 18, n. 7, p. BR253-BR258, 2012. 1234-1010 WOS:000306883300004 1590971576309420 5016839015394547 1213140801402647 7438704034471673 0000-0002-5843-6232 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Medical Science Monitor 0,619 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
BR253-BR258 |
dc.publisher.none.fl_str_mv |
Int Scientific Literature, Inc |
publisher.none.fl_str_mv |
Int Scientific Literature, Inc |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789432347099136 |