Genetics of acheiropodia (the handless and footless families of Brazil). VII. Population dynamics
Autor(a) principal: | |
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Data de Publicação: | 1975 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/230778 |
Resumo: | Since carriers of the acheiropodia gene cannot be distinguished from noncarriers, parents and normal sibs of affected individuals have been used to estimate the fitness of heterozygotes. No significant difference in biologic fitness (viability and fertility) between normal sibs and the general population could be detected. A comparison between acheiropods nonsignificant their normal sibs showed the following: (1) a significant difference in stillbirth rate; (2) a higher mortality rate of acheiropids in the first 5 years of life; (3) a relative viability not larger than .7; (4) a relative fertility no greater than .14, due to 'cosmetic effects'; and (5) a fitness of .10 or lower. The lower number of acheiropodia genes in Brazil has been calculated as 25,000 in the 1970s. The data are compatible with an extremely low mutation rate and a very stable locus. It is suggested that all Brazilian acheiropods can be traced to a single mutation. A conservative estimate of the number of acheiropods to appear in the future in Brazil is 14,000 with an extinction time of no less than 2,300 generations or almost 70,000 years. A variety of other parameters have been calculated. |
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Repositório Institucional da UNESP |
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Genetics of acheiropodia (the handless and footless families of Brazil). VII. Population dynamicsSince carriers of the acheiropodia gene cannot be distinguished from noncarriers, parents and normal sibs of affected individuals have been used to estimate the fitness of heterozygotes. No significant difference in biologic fitness (viability and fertility) between normal sibs and the general population could be detected. A comparison between acheiropods nonsignificant their normal sibs showed the following: (1) a significant difference in stillbirth rate; (2) a higher mortality rate of acheiropids in the first 5 years of life; (3) a relative viability not larger than .7; (4) a relative fertility no greater than .14, due to 'cosmetic effects'; and (5) a fitness of .10 or lower. The lower number of acheiropodia genes in Brazil has been calculated as 25,000 in the 1970s. The data are compatible with an extremely low mutation rate and a very stable locus. It is suggested that all Brazilian acheiropods can be traced to a single mutation. A conservative estimate of the number of acheiropods to appear in the future in Brazil is 14,000 with an extinction time of no less than 2,300 generations or almost 70,000 years. A variety of other parameters have been calculated.Dept. Genet., Fac. Ci. Med. Biol., Botucatu2022-04-29T08:41:59Z2022-04-29T08:41:59Z1975-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article665-675American Journal of Human Genetics, v. 27, n. 5, p. 665-675, 1975.0002-9297http://hdl.handle.net/11449/2307782-s2.0-0016802684Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAmerican Journal of Human GeneticsFreire Maia, A.Li, W. H.Maruyama, T.info:eu-repo/semantics/openAccess2022-04-29T08:41:59Zoai:repositorio.unesp.br:11449/230778Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:41:59Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Genetics of acheiropodia (the handless and footless families of Brazil). VII. Population dynamics |
title |
Genetics of acheiropodia (the handless and footless families of Brazil). VII. Population dynamics |
spellingShingle |
Genetics of acheiropodia (the handless and footless families of Brazil). VII. Population dynamics Freire Maia, A. |
title_short |
Genetics of acheiropodia (the handless and footless families of Brazil). VII. Population dynamics |
title_full |
Genetics of acheiropodia (the handless and footless families of Brazil). VII. Population dynamics |
title_fullStr |
Genetics of acheiropodia (the handless and footless families of Brazil). VII. Population dynamics |
title_full_unstemmed |
Genetics of acheiropodia (the handless and footless families of Brazil). VII. Population dynamics |
title_sort |
Genetics of acheiropodia (the handless and footless families of Brazil). VII. Population dynamics |
author |
Freire Maia, A. |
author_facet |
Freire Maia, A. Li, W. H. Maruyama, T. |
author_role |
author |
author2 |
Li, W. H. Maruyama, T. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Freire Maia, A. Li, W. H. Maruyama, T. |
description |
Since carriers of the acheiropodia gene cannot be distinguished from noncarriers, parents and normal sibs of affected individuals have been used to estimate the fitness of heterozygotes. No significant difference in biologic fitness (viability and fertility) between normal sibs and the general population could be detected. A comparison between acheiropods nonsignificant their normal sibs showed the following: (1) a significant difference in stillbirth rate; (2) a higher mortality rate of acheiropids in the first 5 years of life; (3) a relative viability not larger than .7; (4) a relative fertility no greater than .14, due to 'cosmetic effects'; and (5) a fitness of .10 or lower. The lower number of acheiropodia genes in Brazil has been calculated as 25,000 in the 1970s. The data are compatible with an extremely low mutation rate and a very stable locus. It is suggested that all Brazilian acheiropods can be traced to a single mutation. A conservative estimate of the number of acheiropods to appear in the future in Brazil is 14,000 with an extinction time of no less than 2,300 generations or almost 70,000 years. A variety of other parameters have been calculated. |
publishDate |
1975 |
dc.date.none.fl_str_mv |
1975-12-01 2022-04-29T08:41:59Z 2022-04-29T08:41:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
American Journal of Human Genetics, v. 27, n. 5, p. 665-675, 1975. 0002-9297 http://hdl.handle.net/11449/230778 2-s2.0-0016802684 |
identifier_str_mv |
American Journal of Human Genetics, v. 27, n. 5, p. 665-675, 1975. 0002-9297 2-s2.0-0016802684 |
url |
http://hdl.handle.net/11449/230778 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
American Journal of Human Genetics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
665-675 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964793426149376 |