A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0001-3765201920180452 http://hdl.handle.net/11449/185865 |
Resumo: | The aim of this study was investigate the effects of a low-protein, high-carbohydrate (LPHC) diet introduced to rats soon after weaning. The animals were distributed in the following groups: LPHC45: fed an LPHC diet (6%-protein. 74%-carbohydrate) for 45 days: C-45: fed a control (C) diet (17%-protein, 63%-carbohydrate) for 45 days; R (Reverse): fed with LPHC for 15 days followed by C diet for 30 days. The LPHC45 group showed alterations in the energetic balance with an increase in brown adipose tissue, and in glucose tolerance, and lower final body weight, muscle mass and total protein in blood when compared with C-45 group. The HOMA-IR index was similar between LPHC(45 )and C-45 groups, but this parameter was lower in LPHC45 compared with R groups. Serum adiponectin was higher in LPHC45 group than C-45 and R groups. The R group presented higher fed insulin than C-45 and LPHC45 and higher T4 compared with C-45 group. Total cholesterol in R group was higher when compared with LPHC45 group. Thus, the data show that the change of the diet LPHC for a balanced diet led to different metabolic evolution and suggest that the different response can be due to different levels of adiponectin. |
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A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in ratslow-proteinhigh-carbohydrate dietpost-weaning periodHOMA-IRadiponectinThe aim of this study was investigate the effects of a low-protein, high-carbohydrate (LPHC) diet introduced to rats soon after weaning. The animals were distributed in the following groups: LPHC45: fed an LPHC diet (6%-protein. 74%-carbohydrate) for 45 days: C-45: fed a control (C) diet (17%-protein, 63%-carbohydrate) for 45 days; R (Reverse): fed with LPHC for 15 days followed by C diet for 30 days. The LPHC45 group showed alterations in the energetic balance with an increase in brown adipose tissue, and in glucose tolerance, and lower final body weight, muscle mass and total protein in blood when compared with C-45 group. The HOMA-IR index was similar between LPHC(45 )and C-45 groups, but this parameter was lower in LPHC45 compared with R groups. Serum adiponectin was higher in LPHC45 group than C-45 and R groups. The R group presented higher fed insulin than C-45 and LPHC45 and higher T4 compared with C-45 group. Total cholesterol in R group was higher when compared with LPHC45 group. Thus, the data show that the change of the diet LPHC for a balanced diet led to different metabolic evolution and suggest that the different response can be due to different levels of adiponectin.Univ Fed Mato Grosso, Dept Quim, Av Fernando Correa da Costa 2367, BR-78060900 Cuiaba, MT, BrazilUniv Estado Rio de Janeiro, Inst Biol Alcantara Gomes, Dept Ciencias Fisiol, 5 Andar, BR-20551030 Rio De Janeiro, RJ, BrazilDept Anal Clin Julio de Mesquita Filho, Rua Expedicionarios Brasil 1621, BR-14801902 Araraquara, SP, BrazilDept Anal Clin Julio de Mesquita Filho, Rua Expedicionarios Brasil 1621, BR-14801902 Araraquara, SP, BrazilAcad Brasileira De CienciasUniversidade Federal de Mato Grosso do Sul (UFMS)Universidade do Estado do Rio de Janeiro (UERJ)Universidade Estadual Paulista (Unesp)Ceolin, PatriciaDe Franca, Suelem A.Froelich, MendalliDos Santos, Maisa P.Pereira, Mayara P.Queiroz, Thais S.Da Silva, Flavia H. S.Lisboa, Patricia C.Andrade, Claudia M. B.Baviera, Amanda M. [UNESP]Kawashita, Nair H.2019-10-04T12:39:14Z2019-10-04T12:39:14Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://dx.doi.org/10.1590/0001-3765201920180452Anais Da Academia Brasileira De Ciencias. Rio Janeiro: Acad Brasileira De Ciencias, v. 91, n. 2, 12 p., 2019.0001-3765http://hdl.handle.net/11449/18586510.1590/0001-3765201920180452S0001-37652019000300714WOS:000473789600001S0001-37652019000300714.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais Da Academia Brasileira De Cienciasinfo:eu-repo/semantics/openAccess2024-01-08T06:24:35Zoai:repositorio.unesp.br:11449/185865Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-08T06:24:35Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats |
title |
A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats |
spellingShingle |
A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats Ceolin, Patricia low-protein high-carbohydrate diet post-weaning period HOMA-IR adiponectin |
title_short |
A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats |
title_full |
A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats |
title_fullStr |
A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats |
title_full_unstemmed |
A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats |
title_sort |
A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats |
author |
Ceolin, Patricia |
author_facet |
Ceolin, Patricia De Franca, Suelem A. Froelich, Mendalli Dos Santos, Maisa P. Pereira, Mayara P. Queiroz, Thais S. Da Silva, Flavia H. S. Lisboa, Patricia C. Andrade, Claudia M. B. Baviera, Amanda M. [UNESP] Kawashita, Nair H. |
author_role |
author |
author2 |
De Franca, Suelem A. Froelich, Mendalli Dos Santos, Maisa P. Pereira, Mayara P. Queiroz, Thais S. Da Silva, Flavia H. S. Lisboa, Patricia C. Andrade, Claudia M. B. Baviera, Amanda M. [UNESP] Kawashita, Nair H. |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Mato Grosso do Sul (UFMS) Universidade do Estado do Rio de Janeiro (UERJ) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Ceolin, Patricia De Franca, Suelem A. Froelich, Mendalli Dos Santos, Maisa P. Pereira, Mayara P. Queiroz, Thais S. Da Silva, Flavia H. S. Lisboa, Patricia C. Andrade, Claudia M. B. Baviera, Amanda M. [UNESP] Kawashita, Nair H. |
dc.subject.por.fl_str_mv |
low-protein high-carbohydrate diet post-weaning period HOMA-IR adiponectin |
topic |
low-protein high-carbohydrate diet post-weaning period HOMA-IR adiponectin |
description |
The aim of this study was investigate the effects of a low-protein, high-carbohydrate (LPHC) diet introduced to rats soon after weaning. The animals were distributed in the following groups: LPHC45: fed an LPHC diet (6%-protein. 74%-carbohydrate) for 45 days: C-45: fed a control (C) diet (17%-protein, 63%-carbohydrate) for 45 days; R (Reverse): fed with LPHC for 15 days followed by C diet for 30 days. The LPHC45 group showed alterations in the energetic balance with an increase in brown adipose tissue, and in glucose tolerance, and lower final body weight, muscle mass and total protein in blood when compared with C-45 group. The HOMA-IR index was similar between LPHC(45 )and C-45 groups, but this parameter was lower in LPHC45 compared with R groups. Serum adiponectin was higher in LPHC45 group than C-45 and R groups. The R group presented higher fed insulin than C-45 and LPHC45 and higher T4 compared with C-45 group. Total cholesterol in R group was higher when compared with LPHC45 group. Thus, the data show that the change of the diet LPHC for a balanced diet led to different metabolic evolution and suggest that the different response can be due to different levels of adiponectin. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-04T12:39:14Z 2019-10-04T12:39:14Z 2019-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0001-3765201920180452 Anais Da Academia Brasileira De Ciencias. Rio Janeiro: Acad Brasileira De Ciencias, v. 91, n. 2, 12 p., 2019. 0001-3765 http://hdl.handle.net/11449/185865 10.1590/0001-3765201920180452 S0001-37652019000300714 WOS:000473789600001 S0001-37652019000300714.pdf |
url |
http://dx.doi.org/10.1590/0001-3765201920180452 http://hdl.handle.net/11449/185865 |
identifier_str_mv |
Anais Da Academia Brasileira De Ciencias. Rio Janeiro: Acad Brasileira De Ciencias, v. 91, n. 2, 12 p., 2019. 0001-3765 10.1590/0001-3765201920180452 S0001-37652019000300714 WOS:000473789600001 S0001-37652019000300714.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anais Da Academia Brasileira De Ciencias |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
12 application/pdf |
dc.publisher.none.fl_str_mv |
Acad Brasileira De Ciencias |
publisher.none.fl_str_mv |
Acad Brasileira De Ciencias |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1797790235849916416 |