Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.maturitas.2017.10.011 http://hdl.handle.net/11449/175389 |
Resumo: | Objective To evaluate the association between vitamin D (VD) deficiency and risk factors for metabolic syndrome (MetS) in postmenopausal women. Study design Observational, cross-sectional cohort study. Main outcome measures In this study, 463 women, aged 45–75 years, with amenorrhea >12 months, without VD supplementation or established cardiovascular disease were included. Clinical and anthropometric data were collected. Biochemical parameters, including total cholesterol (TC), HDL, LDL, triglycerides, glucose, insulin and 25-hydroxyvitamin-D [25(OH)D] were measured. Women meeting three or more of the following criteria were diagnosed with MetS: waist circumference >88 cm, triglycerides ≥150 mg/dL, HDL <50 mg/dL, blood pressure ≥130/85 mmHg and glucose ≥100 mg/dL. Serum 25(OH)D levels were classified as sufficient (≥30 ng/mL), insufficient (20–29 ng/mL) or deficient (<20 ng/mL). ANOVA, chi-square test and logistic regression (odds ratio, OR) were used for statistical analysis. Results Serum 25(OH)D levels were sufficient in 148 women (32.0%), insufficient in 151 (32.6%) and deficient in 164 (35.4%). Women with low 25(OH)D levels had higher TC, triglycerides, insulin and HOMA-IR levels (p < 0.05). MetS was detected in 57.8% (182/315) of women with hypovitaminosis D (insufficient and deficient) and in 39.8% (59/148) of those with sufficient VD (p = 0.003). In a multivariate logistic regression analysis, a low 25(OH)D level (<30 ng/mL) was significantly associated with MetS (OR1.90, 95%CI = 1.26–2.85), high triglyceride levels (OR1.55, 95%CI = 1.13–2.35), and low HDL levels (OR1.60, 95%CI = 1.19–2.40) (p < 0.05) compared with women with sufficient 25(OH)D levels, after adjusting for age, time since menopause, body mass index, smoking and physical exercise. The mean concentration of 25(OH)D decreased with increasing numbers of MetS components (p = 0.016). Conclusions VD deficiency in postmenopausal women was associated with a higher prevalence of MetS. Women with VD deficiency had a higher risk of MetS, hypertriglyceridemia and low HDL than those with adequate levels. |
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Repositório Institucional da UNESP |
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Vitamin D deficiency is associated with metabolic syndrome in postmenopausal womenMetabolic syndromePostmenopausal womenVitamin DObjective To evaluate the association between vitamin D (VD) deficiency and risk factors for metabolic syndrome (MetS) in postmenopausal women. Study design Observational, cross-sectional cohort study. Main outcome measures In this study, 463 women, aged 45–75 years, with amenorrhea >12 months, without VD supplementation or established cardiovascular disease were included. Clinical and anthropometric data were collected. Biochemical parameters, including total cholesterol (TC), HDL, LDL, triglycerides, glucose, insulin and 25-hydroxyvitamin-D [25(OH)D] were measured. Women meeting three or more of the following criteria were diagnosed with MetS: waist circumference >88 cm, triglycerides ≥150 mg/dL, HDL <50 mg/dL, blood pressure ≥130/85 mmHg and glucose ≥100 mg/dL. Serum 25(OH)D levels were classified as sufficient (≥30 ng/mL), insufficient (20–29 ng/mL) or deficient (<20 ng/mL). ANOVA, chi-square test and logistic regression (odds ratio, OR) were used for statistical analysis. Results Serum 25(OH)D levels were sufficient in 148 women (32.0%), insufficient in 151 (32.6%) and deficient in 164 (35.4%). Women with low 25(OH)D levels had higher TC, triglycerides, insulin and HOMA-IR levels (p < 0.05). MetS was detected in 57.8% (182/315) of women with hypovitaminosis D (insufficient and deficient) and in 39.8% (59/148) of those with sufficient VD (p = 0.003). In a multivariate logistic regression analysis, a low 25(OH)D level (<30 ng/mL) was significantly associated with MetS (OR1.90, 95%CI = 1.26–2.85), high triglyceride levels (OR1.55, 95%CI = 1.13–2.35), and low HDL levels (OR1.60, 95%CI = 1.19–2.40) (p < 0.05) compared with women with sufficient 25(OH)D levels, after adjusting for age, time since menopause, body mass index, smoking and physical exercise. The mean concentration of 25(OH)D decreased with increasing numbers of MetS components (p = 0.016). Conclusions VD deficiency in postmenopausal women was associated with a higher prevalence of MetS. Women with VD deficiency had a higher risk of MetS, hypertriglyceridemia and low HDL than those with adequate levels.Department of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University – UNESPDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University – UNESPUniversidade Estadual Paulista (Unesp)Schmitt, Eneida Boteon [UNESP]Nahas-Neto, Jorge [UNESP]Bueloni-Dias, Flavia [UNESP]Poloni, Priscila Ferreira [UNESP]Orsatti, Claudio Lera [UNESP]Petri Nahas, Eliana Aguiar [UNESP]2018-12-11T17:15:36Z2018-12-11T17:15:36Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article97-102application/pdfhttp://dx.doi.org/10.1016/j.maturitas.2017.10.011Maturitas, v. 107, p. 97-102.1873-41110378-5122http://hdl.handle.net/11449/17538910.1016/j.maturitas.2017.10.0112-s2.0-850322598192-s2.0-85032259819.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaturitas1,061info:eu-repo/semantics/openAccess2023-12-21T06:18:08Zoai:repositorio.unesp.br:11449/175389Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-21T06:18:08Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women |
title |
Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women |
spellingShingle |
Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women Schmitt, Eneida Boteon [UNESP] Metabolic syndrome Postmenopausal women Vitamin D |
title_short |
Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women |
title_full |
Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women |
title_fullStr |
Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women |
title_full_unstemmed |
Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women |
title_sort |
Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women |
author |
Schmitt, Eneida Boteon [UNESP] |
author_facet |
Schmitt, Eneida Boteon [UNESP] Nahas-Neto, Jorge [UNESP] Bueloni-Dias, Flavia [UNESP] Poloni, Priscila Ferreira [UNESP] Orsatti, Claudio Lera [UNESP] Petri Nahas, Eliana Aguiar [UNESP] |
author_role |
author |
author2 |
Nahas-Neto, Jorge [UNESP] Bueloni-Dias, Flavia [UNESP] Poloni, Priscila Ferreira [UNESP] Orsatti, Claudio Lera [UNESP] Petri Nahas, Eliana Aguiar [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Schmitt, Eneida Boteon [UNESP] Nahas-Neto, Jorge [UNESP] Bueloni-Dias, Flavia [UNESP] Poloni, Priscila Ferreira [UNESP] Orsatti, Claudio Lera [UNESP] Petri Nahas, Eliana Aguiar [UNESP] |
dc.subject.por.fl_str_mv |
Metabolic syndrome Postmenopausal women Vitamin D |
topic |
Metabolic syndrome Postmenopausal women Vitamin D |
description |
Objective To evaluate the association between vitamin D (VD) deficiency and risk factors for metabolic syndrome (MetS) in postmenopausal women. Study design Observational, cross-sectional cohort study. Main outcome measures In this study, 463 women, aged 45–75 years, with amenorrhea >12 months, without VD supplementation or established cardiovascular disease were included. Clinical and anthropometric data were collected. Biochemical parameters, including total cholesterol (TC), HDL, LDL, triglycerides, glucose, insulin and 25-hydroxyvitamin-D [25(OH)D] were measured. Women meeting three or more of the following criteria were diagnosed with MetS: waist circumference >88 cm, triglycerides ≥150 mg/dL, HDL <50 mg/dL, blood pressure ≥130/85 mmHg and glucose ≥100 mg/dL. Serum 25(OH)D levels were classified as sufficient (≥30 ng/mL), insufficient (20–29 ng/mL) or deficient (<20 ng/mL). ANOVA, chi-square test and logistic regression (odds ratio, OR) were used for statistical analysis. Results Serum 25(OH)D levels were sufficient in 148 women (32.0%), insufficient in 151 (32.6%) and deficient in 164 (35.4%). Women with low 25(OH)D levels had higher TC, triglycerides, insulin and HOMA-IR levels (p < 0.05). MetS was detected in 57.8% (182/315) of women with hypovitaminosis D (insufficient and deficient) and in 39.8% (59/148) of those with sufficient VD (p = 0.003). In a multivariate logistic regression analysis, a low 25(OH)D level (<30 ng/mL) was significantly associated with MetS (OR1.90, 95%CI = 1.26–2.85), high triglyceride levels (OR1.55, 95%CI = 1.13–2.35), and low HDL levels (OR1.60, 95%CI = 1.19–2.40) (p < 0.05) compared with women with sufficient 25(OH)D levels, after adjusting for age, time since menopause, body mass index, smoking and physical exercise. The mean concentration of 25(OH)D decreased with increasing numbers of MetS components (p = 0.016). Conclusions VD deficiency in postmenopausal women was associated with a higher prevalence of MetS. Women with VD deficiency had a higher risk of MetS, hypertriglyceridemia and low HDL than those with adequate levels. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:15:36Z 2018-12-11T17:15:36Z 2018-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.maturitas.2017.10.011 Maturitas, v. 107, p. 97-102. 1873-4111 0378-5122 http://hdl.handle.net/11449/175389 10.1016/j.maturitas.2017.10.011 2-s2.0-85032259819 2-s2.0-85032259819.pdf |
url |
http://dx.doi.org/10.1016/j.maturitas.2017.10.011 http://hdl.handle.net/11449/175389 |
identifier_str_mv |
Maturitas, v. 107, p. 97-102. 1873-4111 0378-5122 10.1016/j.maturitas.2017.10.011 2-s2.0-85032259819 2-s2.0-85032259819.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Maturitas 1,061 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
97-102 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1792962132678017024 |