Respuestas musculares de la asociación de estatina y ejercicio físico aeróbico en ratas
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | spa |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4067/S0717-95022009000400031 http://hdl.handle.net/11449/225883 |
Resumo: | Physical exercise and statins, which are recommended for the treatment of dyslipidemia, are independently associated to the occurrence of muscle injury. The objective is analyze the effect of aerobic exercise associated to the use of simvastatin on the morphology of the gastrocnemius muscle. Thirty Wistar rats were divided into six groups, two of which received a standard diet (1 sedentary and 1 exercised) and four (1 sedentary with medication, 1 sedentary without medication, 1 exercised with medication, 1 exercised without medication) received a hypercholesterolemic diet (standard diet with the addition of cholesterol and coconut oil). Simvastatin (20 mg/Kg) was administered five days a week for eight weeks, together with aerobic training on a treadmill (9.75 m/min) for 60 minutes a day. The gastrocnemius muscle was removed, sliced, stained with Hematoxylin-Eosin and submitted to a histochemical reaction to determine mitochondrial activity. The data were analyzed using a paired t-test, analysis of variance and Scheffé's post hoc test (p<0.05). Greater histological alterations were found in the medicated and exercised animals, with a greater frequency of occurrence as well. The histochemical analysis revealed that the medicated groups had fibers with more intensive mitochondrial activity alongside fibers with an absence of reaction. The morphometric analysis revealed no significant differences between groups. It is suggested that simvastatin is a medication that leads to the occurrence of muscle injury and its administration in association with physical activity may exacerbate these injuries. This finding may be related to cellular respiration. |
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Respuestas musculares de la asociación de estatina y ejercicio físico aeróbico en ratasMuscle response to the association of statin and physical exercise in ratsExerciseHydroxymethylglutaryl-coa reductase inhibitorsSkeletal musclePhysical exercise and statins, which are recommended for the treatment of dyslipidemia, are independently associated to the occurrence of muscle injury. The objective is analyze the effect of aerobic exercise associated to the use of simvastatin on the morphology of the gastrocnemius muscle. Thirty Wistar rats were divided into six groups, two of which received a standard diet (1 sedentary and 1 exercised) and four (1 sedentary with medication, 1 sedentary without medication, 1 exercised with medication, 1 exercised without medication) received a hypercholesterolemic diet (standard diet with the addition of cholesterol and coconut oil). Simvastatin (20 mg/Kg) was administered five days a week for eight weeks, together with aerobic training on a treadmill (9.75 m/min) for 60 minutes a day. The gastrocnemius muscle was removed, sliced, stained with Hematoxylin-Eosin and submitted to a histochemical reaction to determine mitochondrial activity. The data were analyzed using a paired t-test, analysis of variance and Scheffé's post hoc test (p<0.05). Greater histological alterations were found in the medicated and exercised animals, with a greater frequency of occurrence as well. The histochemical analysis revealed that the medicated groups had fibers with more intensive mitochondrial activity alongside fibers with an absence of reaction. The morphometric analysis revealed no significant differences between groups. It is suggested that simvastatin is a medication that leads to the occurrence of muscle injury and its administration in association with physical activity may exacerbate these injuries. This finding may be related to cellular respiration.Faculty of Science and Technology (FCT/UNESP), Presidente Prudente/SPDepartment of Physiotherapy Faculty of Science and Technology (FCT/UNESP), Presidente Prudente/SPFaculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto/SPFaculty of Science and Technology (FCT/UNESP), Presidente Prudente/SPDepartment of Physiotherapy Faculty of Science and Technology (FCT/UNESP), Presidente Prudente/SPUniversidade Estadual Paulista (UNESP)Faculty of Medicine of São José do Rio Preto (FAMERP)Bonfim, Mariana Rotta [UNESP]Camargo Filho, José Carlos Silva [UNESP]Vanderlei, Luiz Carlos Marques [UNESP]Padulla, Susimary Aparecida Trevizan [UNESP]Accioly, Marilita FalângolaSouza, Dorotéia Rossi SilvaAzoubel, Reinaldo2022-04-28T21:01:25Z2022-04-28T21:01:25Z2009-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1155-1161http://dx.doi.org/10.4067/S0717-95022009000400031International Journal of Morphology, v. 27, n. 4, p. 1155-1161, 2009.0717-95020717-9367http://hdl.handle.net/11449/22588310.4067/S0717-950220090004000312-s2.0-77953557305Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPspaInternational Journal of Morphologyinfo:eu-repo/semantics/openAccess2022-04-28T21:01:25Zoai:repositorio.unesp.br:11449/225883Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T21:01:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Respuestas musculares de la asociación de estatina y ejercicio físico aeróbico en ratas Muscle response to the association of statin and physical exercise in rats |
title |
Respuestas musculares de la asociación de estatina y ejercicio físico aeróbico en ratas |
spellingShingle |
Respuestas musculares de la asociación de estatina y ejercicio físico aeróbico en ratas Bonfim, Mariana Rotta [UNESP] Exercise Hydroxymethylglutaryl-coa reductase inhibitors Skeletal muscle |
title_short |
Respuestas musculares de la asociación de estatina y ejercicio físico aeróbico en ratas |
title_full |
Respuestas musculares de la asociación de estatina y ejercicio físico aeróbico en ratas |
title_fullStr |
Respuestas musculares de la asociación de estatina y ejercicio físico aeróbico en ratas |
title_full_unstemmed |
Respuestas musculares de la asociación de estatina y ejercicio físico aeróbico en ratas |
title_sort |
Respuestas musculares de la asociación de estatina y ejercicio físico aeróbico en ratas |
author |
Bonfim, Mariana Rotta [UNESP] |
author_facet |
Bonfim, Mariana Rotta [UNESP] Camargo Filho, José Carlos Silva [UNESP] Vanderlei, Luiz Carlos Marques [UNESP] Padulla, Susimary Aparecida Trevizan [UNESP] Accioly, Marilita Falângola Souza, Dorotéia Rossi Silva Azoubel, Reinaldo |
author_role |
author |
author2 |
Camargo Filho, José Carlos Silva [UNESP] Vanderlei, Luiz Carlos Marques [UNESP] Padulla, Susimary Aparecida Trevizan [UNESP] Accioly, Marilita Falângola Souza, Dorotéia Rossi Silva Azoubel, Reinaldo |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Faculty of Medicine of São José do Rio Preto (FAMERP) |
dc.contributor.author.fl_str_mv |
Bonfim, Mariana Rotta [UNESP] Camargo Filho, José Carlos Silva [UNESP] Vanderlei, Luiz Carlos Marques [UNESP] Padulla, Susimary Aparecida Trevizan [UNESP] Accioly, Marilita Falângola Souza, Dorotéia Rossi Silva Azoubel, Reinaldo |
dc.subject.por.fl_str_mv |
Exercise Hydroxymethylglutaryl-coa reductase inhibitors Skeletal muscle |
topic |
Exercise Hydroxymethylglutaryl-coa reductase inhibitors Skeletal muscle |
description |
Physical exercise and statins, which are recommended for the treatment of dyslipidemia, are independently associated to the occurrence of muscle injury. The objective is analyze the effect of aerobic exercise associated to the use of simvastatin on the morphology of the gastrocnemius muscle. Thirty Wistar rats were divided into six groups, two of which received a standard diet (1 sedentary and 1 exercised) and four (1 sedentary with medication, 1 sedentary without medication, 1 exercised with medication, 1 exercised without medication) received a hypercholesterolemic diet (standard diet with the addition of cholesterol and coconut oil). Simvastatin (20 mg/Kg) was administered five days a week for eight weeks, together with aerobic training on a treadmill (9.75 m/min) for 60 minutes a day. The gastrocnemius muscle was removed, sliced, stained with Hematoxylin-Eosin and submitted to a histochemical reaction to determine mitochondrial activity. The data were analyzed using a paired t-test, analysis of variance and Scheffé's post hoc test (p<0.05). Greater histological alterations were found in the medicated and exercised animals, with a greater frequency of occurrence as well. The histochemical analysis revealed that the medicated groups had fibers with more intensive mitochondrial activity alongside fibers with an absence of reaction. The morphometric analysis revealed no significant differences between groups. It is suggested that simvastatin is a medication that leads to the occurrence of muscle injury and its administration in association with physical activity may exacerbate these injuries. This finding may be related to cellular respiration. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 2022-04-28T21:01:25Z 2022-04-28T21:01:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4067/S0717-95022009000400031 International Journal of Morphology, v. 27, n. 4, p. 1155-1161, 2009. 0717-9502 0717-9367 http://hdl.handle.net/11449/225883 10.4067/S0717-95022009000400031 2-s2.0-77953557305 |
url |
http://dx.doi.org/10.4067/S0717-95022009000400031 http://hdl.handle.net/11449/225883 |
identifier_str_mv |
International Journal of Morphology, v. 27, n. 4, p. 1155-1161, 2009. 0717-9502 0717-9367 10.4067/S0717-95022009000400031 2-s2.0-77953557305 |
dc.language.iso.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
International Journal of Morphology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1155-1161 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964994687729664 |