Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus)
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1415-47572007000100012 http://hdl.handle.net/11449/18888 |
Resumo: | We investigated the resistance to Strongyloides venezuelensis primary infection of mice strains NIH (resistant) and C57BL/6 (susceptible) and the F1 and F2 offspring of crosses between these strains. The mice were infected with 2000 larvae and seven days later were sacrificed for parasite recovery and counting. There was no statistically significant (p > 0.05) sex effect on resistance. The F1 mice showed an intermediate mean number of parasites as compared to the parental NIH and C57BL6 strains. Out of 400 F2 mice, the 10% most resistant mice were infected with 21 to 97 parasites, while the 10% most susceptible mice were infected with 1027 to 1433 parasites. We also found that F2 mice with black fur (n = 72), the same color as the C57BL/6 susceptible parental strain, were more susceptible than white (n = 104) or gray furred (n = 224) mice. It is conceivable that some genes determining coat color are located on the same chromosome as where genes controlling helminth resistance. |
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Repositório Institucional da UNESP |
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Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus)miceStrongyloides venezuelensisresistancegeneticsWe investigated the resistance to Strongyloides venezuelensis primary infection of mice strains NIH (resistant) and C57BL/6 (susceptible) and the F1 and F2 offspring of crosses between these strains. The mice were infected with 2000 larvae and seven days later were sacrificed for parasite recovery and counting. There was no statistically significant (p > 0.05) sex effect on resistance. The F1 mice showed an intermediate mean number of parasites as compared to the parental NIH and C57BL6 strains. Out of 400 F2 mice, the 10% most resistant mice were infected with 21 to 97 parasites, while the 10% most susceptible mice were infected with 1027 to 1433 parasites. We also found that F2 mice with black fur (n = 72), the same color as the C57BL/6 susceptible parental strain, were more susceptible than white (n = 104) or gray furred (n = 224) mice. It is conceivable that some genes determining coat color are located on the same chromosome as where genes controlling helminth resistance.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual Paulista Instituto de Biociências Departamento de ParasitologiaUniversidade Estadual Paulista Instituto de Biociências Departamento de ParasitologiaSociedade Brasileira de GenéticaUniversidade Estadual Paulista (Unesp)Marra, Nelson Mendes [UNESP]Amarante, Alessandro Francisco Talamini do [UNESP]Amarante, Mônica R.V. [UNESP]2014-05-20T13:52:56Z2014-05-20T13:52:56Z2007-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article60-64application/pdfhttp://dx.doi.org/10.1590/S1415-47572007000100012Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 30, n. 1, p. 60-64, 2007.1415-4757http://hdl.handle.net/11449/1888810.1590/S1415-47572007000100012S1415-47572007000100012S1415-47572007000100012.pdf267723166332970650793802799335400000-0002-5929-1223SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics and Molecular Biology1.4930,638info:eu-repo/semantics/openAccess2024-01-21T06:24:39Zoai:repositorio.unesp.br:11449/18888Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-21T06:24:39Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus) |
title |
Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus) |
spellingShingle |
Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus) Marra, Nelson Mendes [UNESP] mice Strongyloides venezuelensis resistance genetics |
title_short |
Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus) |
title_full |
Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus) |
title_fullStr |
Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus) |
title_full_unstemmed |
Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus) |
title_sort |
Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus) |
author |
Marra, Nelson Mendes [UNESP] |
author_facet |
Marra, Nelson Mendes [UNESP] Amarante, Alessandro Francisco Talamini do [UNESP] Amarante, Mônica R.V. [UNESP] |
author_role |
author |
author2 |
Amarante, Alessandro Francisco Talamini do [UNESP] Amarante, Mônica R.V. [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Marra, Nelson Mendes [UNESP] Amarante, Alessandro Francisco Talamini do [UNESP] Amarante, Mônica R.V. [UNESP] |
dc.subject.por.fl_str_mv |
mice Strongyloides venezuelensis resistance genetics |
topic |
mice Strongyloides venezuelensis resistance genetics |
description |
We investigated the resistance to Strongyloides venezuelensis primary infection of mice strains NIH (resistant) and C57BL/6 (susceptible) and the F1 and F2 offspring of crosses between these strains. The mice were infected with 2000 larvae and seven days later were sacrificed for parasite recovery and counting. There was no statistically significant (p > 0.05) sex effect on resistance. The F1 mice showed an intermediate mean number of parasites as compared to the parental NIH and C57BL6 strains. Out of 400 F2 mice, the 10% most resistant mice were infected with 21 to 97 parasites, while the 10% most susceptible mice were infected with 1027 to 1433 parasites. We also found that F2 mice with black fur (n = 72), the same color as the C57BL/6 susceptible parental strain, were more susceptible than white (n = 104) or gray furred (n = 224) mice. It is conceivable that some genes determining coat color are located on the same chromosome as where genes controlling helminth resistance. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-01-01 2014-05-20T13:52:56Z 2014-05-20T13:52:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1415-47572007000100012 Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 30, n. 1, p. 60-64, 2007. 1415-4757 http://hdl.handle.net/11449/18888 10.1590/S1415-47572007000100012 S1415-47572007000100012 S1415-47572007000100012.pdf 2677231663329706 5079380279933540 0000-0002-5929-1223 |
url |
http://dx.doi.org/10.1590/S1415-47572007000100012 http://hdl.handle.net/11449/18888 |
identifier_str_mv |
Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 30, n. 1, p. 60-64, 2007. 1415-4757 10.1590/S1415-47572007000100012 S1415-47572007000100012 S1415-47572007000100012.pdf 2677231663329706 5079380279933540 0000-0002-5929-1223 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Genetics and Molecular Biology 1.493 0,638 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
60-64 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1792962396910780416 |