Splenic congestion associated with acepromazine administration in dogs

• Autor(a) principal: Tavares, Denise Cláudia [UNESP]
• Data de Publicação: 2014
• Outros Autores: Souza, Fabiana Ferreira de [UNESP], Olivaes, Claudio Galvão de, Rodrigues, Valeska, Paula, Thais Melo de, Mattos Júnior, Ewaldo de, Toniollo, Gilson Hélio [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.11606/issn.1678-4456.v51i4p304-308; http://hdl.handle.net/11449/137315
• topic: Canis lupus familiaris; Phenothiazines; Splenomegaly; Canis lupus familiaris; Fenotiazínicos; Esplenomegalia

The effects splenic dilatation induced by acepromazine in a prospective, randomized study. Thirtythree adult mongrel dogs were divided into two groups designated as AG (acepromazine 0.05 mg/kg, i.v., n = 23) and CG (0.9% sodium chloride administered at a similar volume, n = 10). In both groups underwent sonographic examinations before (T0) and fifteen minutes (T15) after drug injection. The thickness spleen and splenic vein width were measured. Higher thickness was found in the AG group at T15 (2.47 cm) when compared to that at T0 (2.06 cm, p = 0.016), while the T0 (2.33 cm) and T15 (2.39 cm) measures did not differ within the CG group. Moreover, the splenic vein width was higher (p = 0.013) at T15 than at T0 in the AG group. Based on results of this study, we concluded that acepromazine, in doses of 0.05 mg/kg, promotes splenomegaly in dogs after fifteen minutes of the injection.