Analysis of the TAX1BP1 gene in head and neck cancer patients
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1808-86942010000200008 http://hdl.handle.net/11449/231247 |
Resumo: | In Brazil, there were I4,160 new estimated cases of head and neck cancer for the year of 2008. Smoking and drinking are the main risk factors established in the etiology of this disease. Aim: to assess the T → A polymorphism in gene TAX1BP1 (leu306ile) in patients with head and neck cancer and a control population. Series and methods: a retrospective study in which we assessed the gender, age, smoking and drinking habits of 191 patients with head and neck cancer and 200 individuals without history of neoplasia. The molecular analysis was carried out after genomic DNA extraction by the PCR-RFLP method. Results: there is a predominance of males (84.82%), smokers (91.1%) and drinkers of alcohol (77.49%). Molecular assessment did not show statistically significant differences between the two groups (p = 0.32). The analysis of clinical parameters and polymorphisms showed association with oral cavity cancer (OR: 2.38; CI 95%: 1.18-4.78; p = 0.01), the other parameters were not associated with the polymorphism. Conclusion: There is evidence of association between TAX1BP1 gene polymorphism and oral cavity cancer. For the remaining parameters analyzed, the results do not suggest association with the TAX1BP1 gene polymorphism. |
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Repositório Institucional da UNESP |
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Analysis of the TAX1BP1 gene in head and neck cancer patientsAlcohol drinkingGeneticsHead and neck neoplasmsTobaccoIn Brazil, there were I4,160 new estimated cases of head and neck cancer for the year of 2008. Smoking and drinking are the main risk factors established in the etiology of this disease. Aim: to assess the T → A polymorphism in gene TAX1BP1 (leu306ile) in patients with head and neck cancer and a control population. Series and methods: a retrospective study in which we assessed the gender, age, smoking and drinking habits of 191 patients with head and neck cancer and 200 individuals without history of neoplasia. The molecular analysis was carried out after genomic DNA extraction by the PCR-RFLP method. Results: there is a predominance of males (84.82%), smokers (91.1%) and drinkers of alcohol (77.49%). Molecular assessment did not show statistically significant differences between the two groups (p = 0.32). The analysis of clinical parameters and polymorphisms showed association with oral cavity cancer (OR: 2.38; CI 95%: 1.18-4.78; p = 0.01), the other parameters were not associated with the polymorphism. Conclusion: There is evidence of association between TAX1BP1 gene polymorphism and oral cavity cancer. For the remaining parameters analyzed, the results do not suggest association with the TAX1BP1 gene polymorphism.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Genetics and Molecular Biology Unit Medical School FAMERPUNESP São José do Rio PretoMedical School São José do Rio Preto FAMERPUNORP São José do Rio PretoDepartment of Otolaryngology and Head and Neck SurgeryDepartment of Human GeneticsMolecular Biology Department Medical School FAMERPUnidade de Pesquisa em Genética e Biologia Molecular UPGEM, Av. Brigadeiro Faria Lima 5416 bloco U-6, São José do Rio Preto 15090-000Fundação de Amparo À Pesquisa do Estado de São Paulo (FAPESP) Centro Nacional de Desenvolvimento Científico e Tecnológico (CNPq)UNESP São José do Rio PretoFAMERPUniversidade Estadual Paulista (UNESP)São José do Rio PretoUPGEMCentro Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Ruiz, Mariangela TorreglosaBalachi, Janayna Fernanda [UNESP]Fernandes, Raquel AldrighiGalbiatti, Ana Lívia SilvaManigua, José VictorPavarino-Bertelli, Érika CristinaGoloni-Bertollo, Eny Maria2022-04-29T08:44:20Z2022-04-29T08:44:20Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article193-198http://dx.doi.org/10.1590/S1808-86942010000200008Brazilian Journal of Otorhinolaryngology, v. 76, n. 2, p. 193-198, 2010.1808-86861808-8694http://hdl.handle.net/11449/23124710.1590/S1808-869420100002000082-s2.0-77957353833Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Otorhinolaryngologyinfo:eu-repo/semantics/openAccess2022-04-29T08:44:20Zoai:repositorio.unesp.br:11449/231247Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:44:20Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Analysis of the TAX1BP1 gene in head and neck cancer patients |
title |
Analysis of the TAX1BP1 gene in head and neck cancer patients |
spellingShingle |
Analysis of the TAX1BP1 gene in head and neck cancer patients Ruiz, Mariangela Torreglosa Alcohol drinking Genetics Head and neck neoplasms Tobacco |
title_short |
Analysis of the TAX1BP1 gene in head and neck cancer patients |
title_full |
Analysis of the TAX1BP1 gene in head and neck cancer patients |
title_fullStr |
Analysis of the TAX1BP1 gene in head and neck cancer patients |
title_full_unstemmed |
Analysis of the TAX1BP1 gene in head and neck cancer patients |
title_sort |
Analysis of the TAX1BP1 gene in head and neck cancer patients |
author |
Ruiz, Mariangela Torreglosa |
author_facet |
Ruiz, Mariangela Torreglosa Balachi, Janayna Fernanda [UNESP] Fernandes, Raquel Aldrighi Galbiatti, Ana Lívia Silva Manigua, José Victor Pavarino-Bertelli, Érika Cristina Goloni-Bertollo, Eny Maria |
author_role |
author |
author2 |
Balachi, Janayna Fernanda [UNESP] Fernandes, Raquel Aldrighi Galbiatti, Ana Lívia Silva Manigua, José Victor Pavarino-Bertelli, Érika Cristina Goloni-Bertollo, Eny Maria |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
FAMERP Universidade Estadual Paulista (UNESP) São José do Rio Preto UPGEM Centro Nacional de Desenvolvimento Científico e Tecnológico (CNPq) |
dc.contributor.author.fl_str_mv |
Ruiz, Mariangela Torreglosa Balachi, Janayna Fernanda [UNESP] Fernandes, Raquel Aldrighi Galbiatti, Ana Lívia Silva Manigua, José Victor Pavarino-Bertelli, Érika Cristina Goloni-Bertollo, Eny Maria |
dc.subject.por.fl_str_mv |
Alcohol drinking Genetics Head and neck neoplasms Tobacco |
topic |
Alcohol drinking Genetics Head and neck neoplasms Tobacco |
description |
In Brazil, there were I4,160 new estimated cases of head and neck cancer for the year of 2008. Smoking and drinking are the main risk factors established in the etiology of this disease. Aim: to assess the T → A polymorphism in gene TAX1BP1 (leu306ile) in patients with head and neck cancer and a control population. Series and methods: a retrospective study in which we assessed the gender, age, smoking and drinking habits of 191 patients with head and neck cancer and 200 individuals without history of neoplasia. The molecular analysis was carried out after genomic DNA extraction by the PCR-RFLP method. Results: there is a predominance of males (84.82%), smokers (91.1%) and drinkers of alcohol (77.49%). Molecular assessment did not show statistically significant differences between the two groups (p = 0.32). The analysis of clinical parameters and polymorphisms showed association with oral cavity cancer (OR: 2.38; CI 95%: 1.18-4.78; p = 0.01), the other parameters were not associated with the polymorphism. Conclusion: There is evidence of association between TAX1BP1 gene polymorphism and oral cavity cancer. For the remaining parameters analyzed, the results do not suggest association with the TAX1BP1 gene polymorphism. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 2022-04-29T08:44:20Z 2022-04-29T08:44:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1808-86942010000200008 Brazilian Journal of Otorhinolaryngology, v. 76, n. 2, p. 193-198, 2010. 1808-8686 1808-8694 http://hdl.handle.net/11449/231247 10.1590/S1808-86942010000200008 2-s2.0-77957353833 |
url |
http://dx.doi.org/10.1590/S1808-86942010000200008 http://hdl.handle.net/11449/231247 |
identifier_str_mv |
Brazilian Journal of Otorhinolaryngology, v. 76, n. 2, p. 193-198, 2010. 1808-8686 1808-8694 10.1590/S1808-86942010000200008 2-s2.0-77957353833 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Otorhinolaryngology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
193-198 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964871460126720 |