Valores de ferritina sérica em beta talassemia heterozigota
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1516-84842010000200018 http://hdl.handle.net/11449/21403 |
Resumo: | A low iron level, the commonest nutritional deficiency in the world, is a public health problem in developing countries. on the other hand, an excessive amount of iron is toxic, causing several organic dysfunctions, such as diabetes, cirrhosis, endocrinopathies and heart disease. Researchers have reported an association of iron overload with beta-thalassemia. The aim of this paper was to compare the serum ferritin levels of women with the beta-thalassemia trait. The results of serologic tests of 137 women of childbearing age were analyzed; 63 had the beta-thalassemia trait and 74 had Hb AA. In the beta-thalassemia carriers, the median ferritin value was 51.90 ng/mL and in the non-carriers 31.60 ng/mL (p = 0.0052). Levels of less than 20 and above 150 ng/mL were observed in 28% and 3% of the non-carriers and in 16% and 11% of the carriers, respectively. With these results it is possible to conclude that women in the reproductive age with the beta-thalassemia trait present higher ferritin levels in the northeastern region of São Paulo State. Further studies are necessary to clarify possible genetic and/or environment factors which interfere in iron absorption. |
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Valores de ferritina sérica em beta talassemia heterozigotaSerum ferritin levels in beta thalassemia carrierBeta-thalassemiaferritinsiron deficiencyA low iron level, the commonest nutritional deficiency in the world, is a public health problem in developing countries. on the other hand, an excessive amount of iron is toxic, causing several organic dysfunctions, such as diabetes, cirrhosis, endocrinopathies and heart disease. Researchers have reported an association of iron overload with beta-thalassemia. The aim of this paper was to compare the serum ferritin levels of women with the beta-thalassemia trait. The results of serologic tests of 137 women of childbearing age were analyzed; 63 had the beta-thalassemia trait and 74 had Hb AA. In the beta-thalassemia carriers, the median ferritin value was 51.90 ng/mL and in the non-carriers 31.60 ng/mL (p = 0.0052). Levels of less than 20 and above 150 ng/mL were observed in 28% and 3% of the non-carriers and in 16% and 11% of the carriers, respectively. With these results it is possible to conclude that women in the reproductive age with the beta-thalassemia trait present higher ferritin levels in the northeastern region of São Paulo State. Further studies are necessary to clarify possible genetic and/or environment factors which interfere in iron absorption.UFSCarUnilabUnespUnespAssociação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula ÓsseaUniversidade Federal de São Carlos (UFSCar)Universidade Federal da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB)Universidade Estadual Paulista (Unesp)Estevão, Isabeth F.Souza, Maria Cristina S.Manzato, Antonio J. [UNESP]Bonini-Domingos, Claudia R. [UNESP]2014-05-20T14:00:30Z2014-05-20T14:00:30Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article171-172application/pdfhttp://dx.doi.org/10.1590/S1516-84842010000200018Revista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, v. 32, n. 2, p. 171-172, 2010.1516-8484http://hdl.handle.net/11449/2140310.1590/S1516-84842010000200018S1516-84842010000200018S1516-84842010000200018.pdf32794280661767190000-0002-4603-9467SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira de Hematologia e Hemoterapia0,335info:eu-repo/semantics/openAccess2023-11-23T06:18:12Zoai:repositorio.unesp.br:11449/21403Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-23T06:18:12Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Valores de ferritina sérica em beta talassemia heterozigota Serum ferritin levels in beta thalassemia carrier |
title |
Valores de ferritina sérica em beta talassemia heterozigota |
spellingShingle |
Valores de ferritina sérica em beta talassemia heterozigota Estevão, Isabeth F. Beta-thalassemia ferritins iron deficiency |
title_short |
Valores de ferritina sérica em beta talassemia heterozigota |
title_full |
Valores de ferritina sérica em beta talassemia heterozigota |
title_fullStr |
Valores de ferritina sérica em beta talassemia heterozigota |
title_full_unstemmed |
Valores de ferritina sérica em beta talassemia heterozigota |
title_sort |
Valores de ferritina sérica em beta talassemia heterozigota |
author |
Estevão, Isabeth F. |
author_facet |
Estevão, Isabeth F. Souza, Maria Cristina S. Manzato, Antonio J. [UNESP] Bonini-Domingos, Claudia R. [UNESP] |
author_role |
author |
author2 |
Souza, Maria Cristina S. Manzato, Antonio J. [UNESP] Bonini-Domingos, Claudia R. [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Carlos (UFSCar) Universidade Federal da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Estevão, Isabeth F. Souza, Maria Cristina S. Manzato, Antonio J. [UNESP] Bonini-Domingos, Claudia R. [UNESP] |
dc.subject.por.fl_str_mv |
Beta-thalassemia ferritins iron deficiency |
topic |
Beta-thalassemia ferritins iron deficiency |
description |
A low iron level, the commonest nutritional deficiency in the world, is a public health problem in developing countries. on the other hand, an excessive amount of iron is toxic, causing several organic dysfunctions, such as diabetes, cirrhosis, endocrinopathies and heart disease. Researchers have reported an association of iron overload with beta-thalassemia. The aim of this paper was to compare the serum ferritin levels of women with the beta-thalassemia trait. The results of serologic tests of 137 women of childbearing age were analyzed; 63 had the beta-thalassemia trait and 74 had Hb AA. In the beta-thalassemia carriers, the median ferritin value was 51.90 ng/mL and in the non-carriers 31.60 ng/mL (p = 0.0052). Levels of less than 20 and above 150 ng/mL were observed in 28% and 3% of the non-carriers and in 16% and 11% of the carriers, respectively. With these results it is possible to conclude that women in the reproductive age with the beta-thalassemia trait present higher ferritin levels in the northeastern region of São Paulo State. Further studies are necessary to clarify possible genetic and/or environment factors which interfere in iron absorption. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 2014-05-20T14:00:30Z 2014-05-20T14:00:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1516-84842010000200018 Revista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, v. 32, n. 2, p. 171-172, 2010. 1516-8484 http://hdl.handle.net/11449/21403 10.1590/S1516-84842010000200018 S1516-84842010000200018 S1516-84842010000200018.pdf 3279428066176719 0000-0002-4603-9467 |
url |
http://dx.doi.org/10.1590/S1516-84842010000200018 http://hdl.handle.net/11449/21403 |
identifier_str_mv |
Revista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, v. 32, n. 2, p. 171-172, 2010. 1516-8484 10.1590/S1516-84842010000200018 S1516-84842010000200018 S1516-84842010000200018.pdf 3279428066176719 0000-0002-4603-9467 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia 0,335 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
171-172 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea |
publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1792961902333132800 |