Anti-inflammatory action of ethanolic extract and clerodane diterpenes from Casearia sylvestris
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bjp.2016.12.008 http://hdl.handle.net/11449/163098 |
Resumo: | The present study aimed to investigate the anti-inflammatory activity of ethanolic extract from Casearia sylvestris Sw., Salicaceae, leaves and to identify the compounds responsible for this activity. The ethanolic extract from C. sylvestris leaves was fractionated by solid phase extraction and the chemical composition of extract and fractions were assessed by chromatographic techniques. Casearin-like clerodane diterpenes were quantified in ethanolic extract (27.4%, w/w) and in fraction 2 of solid phase extraction (50.6%, w/w). Carrageenan-induced paw edema and carrageenan-induced pleurisy assays (rats) were used to evaluate anti-inflammatory activity of ethanolic extract, its fractions and clerodane diterpenes from C. sylvestris caseargrewiin F and casearin B. The ethanolic extract was tested in the rat paw edema model and the doses tested (10 and 100 mg/kg) had no effect. In the pleurisy model, the extract doses of 300 and 500 mg/kg showed inhibitory effect. The fraction 2 of solid phase extraction (10 mg/kg), caseargrewiin F and casearin B (0.5 mg/kg) showed a significant reduction (p < 0.05) of the carrageenan-induced paw edema in rats compared to indomethacin. Gastric ulcers were not observed in animals treated with samples from C. sylvestris. In conclusion, the ethanolic extract from C. sylvestris, its enriched fraction of clerodane diterpenes, casearin B and caseargrewiin F exhibited anti-inflammatory activity on in vivo models in rats. Casearin-like clerodane diterpenes may be considered active chemical markers for C. sylvestris leaves. On the other hand, these diterpenes are promising compounds in the development of new drugs with anti-inflammatory action without gastric side effects. (c) 2017 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. |
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Anti-inflammatory action of ethanolic extract and clerodane diterpenes from Casearia sylvestrisClerodane diterpeneCasearin BCaseargrewiin FAnti-inflammatory activityGastric side effectsThe present study aimed to investigate the anti-inflammatory activity of ethanolic extract from Casearia sylvestris Sw., Salicaceae, leaves and to identify the compounds responsible for this activity. The ethanolic extract from C. sylvestris leaves was fractionated by solid phase extraction and the chemical composition of extract and fractions were assessed by chromatographic techniques. Casearin-like clerodane diterpenes were quantified in ethanolic extract (27.4%, w/w) and in fraction 2 of solid phase extraction (50.6%, w/w). Carrageenan-induced paw edema and carrageenan-induced pleurisy assays (rats) were used to evaluate anti-inflammatory activity of ethanolic extract, its fractions and clerodane diterpenes from C. sylvestris caseargrewiin F and casearin B. The ethanolic extract was tested in the rat paw edema model and the doses tested (10 and 100 mg/kg) had no effect. In the pleurisy model, the extract doses of 300 and 500 mg/kg showed inhibitory effect. The fraction 2 of solid phase extraction (10 mg/kg), caseargrewiin F and casearin B (0.5 mg/kg) showed a significant reduction (p < 0.05) of the carrageenan-induced paw edema in rats compared to indomethacin. Gastric ulcers were not observed in animals treated with samples from C. sylvestris. In conclusion, the ethanolic extract from C. sylvestris, its enriched fraction of clerodane diterpenes, casearin B and caseargrewiin F exhibited anti-inflammatory activity on in vivo models in rats. Casearin-like clerodane diterpenes may be considered active chemical markers for C. sylvestris leaves. On the other hand, these diterpenes are promising compounds in the development of new drugs with anti-inflammatory action without gastric side effects. (c) 2017 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda.Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Principios Ativos Nat & Toxicol, Lab Farmacognosia, Araraquara, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Farm & Med, Lab Pesquisa Desenvolvimento Farm, Araraquara, SP, BrazilUniv Estadual Paulista, Inst Quim, Dept Quim Organ, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, Araraquara, SP, BrazilInst Fed Sao Paulo, Campus Avancado Matao, Matao, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Principios Ativos Nat & Toxicol, Lab Farmacognosia, Araraquara, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Farm & Med, Lab Pesquisa Desenvolvimento Farm, Araraquara, SP, BrazilUniv Estadual Paulista, Inst Quim, Dept Quim Organ, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, Araraquara, SP, BrazilSoc Brasileira FarmacognosiaUniversidade Estadual Paulista (Unesp)Inst Fed Sao PauloPierri, Elaise G. [UNESP]Castro, Rogerio C. [UNESP]Vizioli, Ednir O. [UNESP]Ferreira, Carla M. R. [UNESP]Cavalheiro, Alberto J. [UNESP]Tininis, Aristeu G.Chin, Chung M. [UNESP]Santos, Andre G. [UNESP]2018-11-26T17:40:05Z2018-11-26T17:40:05Z2017-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article495-501application/pdfhttp://dx.doi.org/10.1016/j.bjp.2016.12.008Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Curitiba-pr: Soc Brasileira Farmacognosia, v. 27, n. 4, p. 495-501, 2017.0102-695Xhttp://hdl.handle.net/11449/16309810.1016/j.bjp.2016.12.008S0102-695X2017000400495WOS:000406961700015S0102-695X2017000400495.pdf97343336079754130000-0003-4141-0455Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosyinfo:eu-repo/semantics/openAccess2023-10-25T06:06:14Zoai:repositorio.unesp.br:11449/163098Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-25T06:06:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Anti-inflammatory action of ethanolic extract and clerodane diterpenes from Casearia sylvestris |
title |
Anti-inflammatory action of ethanolic extract and clerodane diterpenes from Casearia sylvestris |
spellingShingle |
Anti-inflammatory action of ethanolic extract and clerodane diterpenes from Casearia sylvestris Pierri, Elaise G. [UNESP] Clerodane diterpene Casearin B Caseargrewiin F Anti-inflammatory activity Gastric side effects |
title_short |
Anti-inflammatory action of ethanolic extract and clerodane diterpenes from Casearia sylvestris |
title_full |
Anti-inflammatory action of ethanolic extract and clerodane diterpenes from Casearia sylvestris |
title_fullStr |
Anti-inflammatory action of ethanolic extract and clerodane diterpenes from Casearia sylvestris |
title_full_unstemmed |
Anti-inflammatory action of ethanolic extract and clerodane diterpenes from Casearia sylvestris |
title_sort |
Anti-inflammatory action of ethanolic extract and clerodane diterpenes from Casearia sylvestris |
author |
Pierri, Elaise G. [UNESP] |
author_facet |
Pierri, Elaise G. [UNESP] Castro, Rogerio C. [UNESP] Vizioli, Ednir O. [UNESP] Ferreira, Carla M. R. [UNESP] Cavalheiro, Alberto J. [UNESP] Tininis, Aristeu G. Chin, Chung M. [UNESP] Santos, Andre G. [UNESP] |
author_role |
author |
author2 |
Castro, Rogerio C. [UNESP] Vizioli, Ednir O. [UNESP] Ferreira, Carla M. R. [UNESP] Cavalheiro, Alberto J. [UNESP] Tininis, Aristeu G. Chin, Chung M. [UNESP] Santos, Andre G. [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Inst Fed Sao Paulo |
dc.contributor.author.fl_str_mv |
Pierri, Elaise G. [UNESP] Castro, Rogerio C. [UNESP] Vizioli, Ednir O. [UNESP] Ferreira, Carla M. R. [UNESP] Cavalheiro, Alberto J. [UNESP] Tininis, Aristeu G. Chin, Chung M. [UNESP] Santos, Andre G. [UNESP] |
dc.subject.por.fl_str_mv |
Clerodane diterpene Casearin B Caseargrewiin F Anti-inflammatory activity Gastric side effects |
topic |
Clerodane diterpene Casearin B Caseargrewiin F Anti-inflammatory activity Gastric side effects |
description |
The present study aimed to investigate the anti-inflammatory activity of ethanolic extract from Casearia sylvestris Sw., Salicaceae, leaves and to identify the compounds responsible for this activity. The ethanolic extract from C. sylvestris leaves was fractionated by solid phase extraction and the chemical composition of extract and fractions were assessed by chromatographic techniques. Casearin-like clerodane diterpenes were quantified in ethanolic extract (27.4%, w/w) and in fraction 2 of solid phase extraction (50.6%, w/w). Carrageenan-induced paw edema and carrageenan-induced pleurisy assays (rats) were used to evaluate anti-inflammatory activity of ethanolic extract, its fractions and clerodane diterpenes from C. sylvestris caseargrewiin F and casearin B. The ethanolic extract was tested in the rat paw edema model and the doses tested (10 and 100 mg/kg) had no effect. In the pleurisy model, the extract doses of 300 and 500 mg/kg showed inhibitory effect. The fraction 2 of solid phase extraction (10 mg/kg), caseargrewiin F and casearin B (0.5 mg/kg) showed a significant reduction (p < 0.05) of the carrageenan-induced paw edema in rats compared to indomethacin. Gastric ulcers were not observed in animals treated with samples from C. sylvestris. In conclusion, the ethanolic extract from C. sylvestris, its enriched fraction of clerodane diterpenes, casearin B and caseargrewiin F exhibited anti-inflammatory activity on in vivo models in rats. Casearin-like clerodane diterpenes may be considered active chemical markers for C. sylvestris leaves. On the other hand, these diterpenes are promising compounds in the development of new drugs with anti-inflammatory action without gastric side effects. (c) 2017 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-07-01 2018-11-26T17:40:05Z 2018-11-26T17:40:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bjp.2016.12.008 Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Curitiba-pr: Soc Brasileira Farmacognosia, v. 27, n. 4, p. 495-501, 2017. 0102-695X http://hdl.handle.net/11449/163098 10.1016/j.bjp.2016.12.008 S0102-695X2017000400495 WOS:000406961700015 S0102-695X2017000400495.pdf 9734333607975413 0000-0003-4141-0455 |
url |
http://dx.doi.org/10.1016/j.bjp.2016.12.008 http://hdl.handle.net/11449/163098 |
identifier_str_mv |
Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Curitiba-pr: Soc Brasileira Farmacognosia, v. 27, n. 4, p. 495-501, 2017. 0102-695X 10.1016/j.bjp.2016.12.008 S0102-695X2017000400495 WOS:000406961700015 S0102-695X2017000400495.pdf 9734333607975413 0000-0003-4141-0455 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
495-501 application/pdf |
dc.publisher.none.fl_str_mv |
Soc Brasileira Farmacognosia |
publisher.none.fl_str_mv |
Soc Brasileira Farmacognosia |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964688982736896 |