E-cig might cause cell damage of oral mucosa
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.oooo.2020.11.009 http://hdl.handle.net/11449/208423 |
Resumo: | Objective: The aim of this study was to investigate cytogenetic and cytotoxic damage through the evaluation of micronuclei (MN) and metanuclear anomalies in the oral mucosa of electronic cigarette (e-cig) users. Study Design: The patients were recruited into 4 groups: e-cig users, smokers, former smokers, and nonsmokers (control). The samples were collected by means of exfoliative cytology of the lateral region of the tongue and the floor of the mouth. The smears obtained were fixed and stained by the Feulgen method for investigation of MN and metanuclear anomalies. Results: A significant difference was observed for MN frequency only between the smoker and control groups. As for metanuclear anomalies, significant differences were observed: karyolysis between: smokers and control, e-cig and control, as well as former smokers; karyorrhexis: between smoker and control; binucleation: between e-cig and former smoker, as well as control; broken eggs: between e-cig and all other groups; nuclear bud: between e-cig and former smokers, as well as control. Conclusions: E-cig and alcohol users presented genotoxicity and cytotoxicity in the oral mucosa cells. The use of e-cigs and alcohol by former smokers can cause more damage to the cells of the oral mucosa compared to those who have not used e-cigs. |
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spelling |
E-cig might cause cell damage of oral mucosaObjective: The aim of this study was to investigate cytogenetic and cytotoxic damage through the evaluation of micronuclei (MN) and metanuclear anomalies in the oral mucosa of electronic cigarette (e-cig) users. Study Design: The patients were recruited into 4 groups: e-cig users, smokers, former smokers, and nonsmokers (control). The samples were collected by means of exfoliative cytology of the lateral region of the tongue and the floor of the mouth. The smears obtained were fixed and stained by the Feulgen method for investigation of MN and metanuclear anomalies. Results: A significant difference was observed for MN frequency only between the smoker and control groups. As for metanuclear anomalies, significant differences were observed: karyolysis between: smokers and control, e-cig and control, as well as former smokers; karyorrhexis: between smoker and control; binucleation: between e-cig and former smoker, as well as control; broken eggs: between e-cig and all other groups; nuclear bud: between e-cig and former smokers, as well as control. Conclusions: E-cig and alcohol users presented genotoxicity and cytotoxicity in the oral mucosa cells. The use of e-cigs and alcohol by former smokers can cause more damage to the cells of the oral mucosa compared to those who have not used e-cigs.Department of Biosciences and Diagnosis Institute of Science and Technology São Paulo State University (Unesp)School of Dentistry Universidade Mogi das CruzesSchool of Medicine Universidade Anhembi MorumbiOutpatient Smoking Treatment Program of the Heart Institute (Incor) Faculty of Medicine University of São Paulo (FMUSP)Department of Biosciences and Diagnosis Institute of Science and Technology São Paulo State University (Unesp)Universidade Estadual Paulista (Unesp)Universidade Mogi das CruzesUniversidade Anhembi MorumbiUniversidade de São Paulo (USP)Schwarzmeier, Lígia Ângelo Tavares [UNESP]da Cruz, Beatriz Serralheiro [UNESP]Ferreira, Camila Cristina Panisello [UNESP]Carvalho, Bruna Fernandes do Carmo [UNESP]Alves, Mônica Ghislaine OliveiraLima Carta, Celina Faig [UNESP]Scholz, Jaqueline RibeiroAlmeida, Janete Dias [UNESP]2021-06-25T11:11:54Z2021-06-25T11:11:54Z2021-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article435-443http://dx.doi.org/10.1016/j.oooo.2020.11.009Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, v. 131, n. 4, p. 435-443, 2021.2212-4403http://hdl.handle.net/11449/20842310.1016/j.oooo.2020.11.0092-s2.0-85101084922Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengOral Surgery, Oral Medicine, Oral Pathology and Oral Radiologyinfo:eu-repo/semantics/openAccess2021-10-23T19:02:10Zoai:repositorio.unesp.br:11449/208423Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T19:02:10Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
E-cig might cause cell damage of oral mucosa |
title |
E-cig might cause cell damage of oral mucosa |
spellingShingle |
E-cig might cause cell damage of oral mucosa Schwarzmeier, Lígia Ângelo Tavares [UNESP] |
title_short |
E-cig might cause cell damage of oral mucosa |
title_full |
E-cig might cause cell damage of oral mucosa |
title_fullStr |
E-cig might cause cell damage of oral mucosa |
title_full_unstemmed |
E-cig might cause cell damage of oral mucosa |
title_sort |
E-cig might cause cell damage of oral mucosa |
author |
Schwarzmeier, Lígia Ângelo Tavares [UNESP] |
author_facet |
Schwarzmeier, Lígia Ângelo Tavares [UNESP] da Cruz, Beatriz Serralheiro [UNESP] Ferreira, Camila Cristina Panisello [UNESP] Carvalho, Bruna Fernandes do Carmo [UNESP] Alves, Mônica Ghislaine Oliveira Lima Carta, Celina Faig [UNESP] Scholz, Jaqueline Ribeiro Almeida, Janete Dias [UNESP] |
author_role |
author |
author2 |
da Cruz, Beatriz Serralheiro [UNESP] Ferreira, Camila Cristina Panisello [UNESP] Carvalho, Bruna Fernandes do Carmo [UNESP] Alves, Mônica Ghislaine Oliveira Lima Carta, Celina Faig [UNESP] Scholz, Jaqueline Ribeiro Almeida, Janete Dias [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Mogi das Cruzes Universidade Anhembi Morumbi Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Schwarzmeier, Lígia Ângelo Tavares [UNESP] da Cruz, Beatriz Serralheiro [UNESP] Ferreira, Camila Cristina Panisello [UNESP] Carvalho, Bruna Fernandes do Carmo [UNESP] Alves, Mônica Ghislaine Oliveira Lima Carta, Celina Faig [UNESP] Scholz, Jaqueline Ribeiro Almeida, Janete Dias [UNESP] |
description |
Objective: The aim of this study was to investigate cytogenetic and cytotoxic damage through the evaluation of micronuclei (MN) and metanuclear anomalies in the oral mucosa of electronic cigarette (e-cig) users. Study Design: The patients were recruited into 4 groups: e-cig users, smokers, former smokers, and nonsmokers (control). The samples were collected by means of exfoliative cytology of the lateral region of the tongue and the floor of the mouth. The smears obtained were fixed and stained by the Feulgen method for investigation of MN and metanuclear anomalies. Results: A significant difference was observed for MN frequency only between the smoker and control groups. As for metanuclear anomalies, significant differences were observed: karyolysis between: smokers and control, e-cig and control, as well as former smokers; karyorrhexis: between smoker and control; binucleation: between e-cig and former smoker, as well as control; broken eggs: between e-cig and all other groups; nuclear bud: between e-cig and former smokers, as well as control. Conclusions: E-cig and alcohol users presented genotoxicity and cytotoxicity in the oral mucosa cells. The use of e-cigs and alcohol by former smokers can cause more damage to the cells of the oral mucosa compared to those who have not used e-cigs. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T11:11:54Z 2021-06-25T11:11:54Z 2021-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.oooo.2020.11.009 Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, v. 131, n. 4, p. 435-443, 2021. 2212-4403 http://hdl.handle.net/11449/208423 10.1016/j.oooo.2020.11.009 2-s2.0-85101084922 |
url |
http://dx.doi.org/10.1016/j.oooo.2020.11.009 http://hdl.handle.net/11449/208423 |
identifier_str_mv |
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, v. 131, n. 4, p. 435-443, 2021. 2212-4403 10.1016/j.oooo.2020.11.009 2-s2.0-85101084922 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
435-443 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965400956403712 |