In vitro inhibition of protein glycation and advanced glycation end products formation by hydroethanolic extract and two fractions of Simaba trichilioides roots
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/14786419.2018.1537276 http://hdl.handle.net/11449/188539 |
Resumo: | Long-term hyperglycemia maintenance is responsible for increased protein glycation and formation of advanced glycation end products (AGEs), both are associated with the onset of diabetes mellitus complications. Efforts have been made to discover new agents having antiglycation potential. The aim of this study was to investigate the effects of the hydroethanolic extract and the ethyl acetate and methanolic fractions of Simaba trichilioides roots on the formation of AGEs. In an in vitro model system of protein glycation, incubations with hydroethanolic extract, ethyl acetate or methanolic fractions of S. trichilioides decreased the fluorescent AGEs, and markers of tyrosine and tryptophan oxidation. Protein crosslinking was reduced in the presence of the ethyl acetate fraction of S. trichilioides. Simaba trichilioides roots seem to be a promising source of compounds having ability to prevent glycoxidation changes, with potential applications in complementary therapies for management of diabetic complications. |
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Repositório Institucional da UNESP |
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In vitro inhibition of protein glycation and advanced glycation end products formation by hydroethanolic extract and two fractions of Simaba trichilioides rootsantiglycation activitydiabetes mellitusglycoxidative stressSimaba trichilioides A St.-HillSimaroubaceaeLong-term hyperglycemia maintenance is responsible for increased protein glycation and formation of advanced glycation end products (AGEs), both are associated with the onset of diabetes mellitus complications. Efforts have been made to discover new agents having antiglycation potential. The aim of this study was to investigate the effects of the hydroethanolic extract and the ethyl acetate and methanolic fractions of Simaba trichilioides roots on the formation of AGEs. In an in vitro model system of protein glycation, incubations with hydroethanolic extract, ethyl acetate or methanolic fractions of S. trichilioides decreased the fluorescent AGEs, and markers of tyrosine and tryptophan oxidation. Protein crosslinking was reduced in the presence of the ethyl acetate fraction of S. trichilioides. Simaba trichilioides roots seem to be a promising source of compounds having ability to prevent glycoxidation changes, with potential applications in complementary therapies for management of diabetic complications.Department of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University–UNESPDepartment of Chemistry Federal University of Mato GrossoDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University–UNESPUniversidade Estadual Paulista (Unesp)Federal University of Mato GrossoMotta, Bruno Pereira [UNESP]Kaga, Anderson Kiyoshi [UNESP]Oliveira, Juliana Oriel [UNESP]Inacio, Maiara Destro [UNESP]da Silva, Cledson Ferreirade Sousa Junior, Paulo TeixeiraBrunetti, Iguatemy Lourenço [UNESP]Baviera, Amanda Martins [UNESP]2019-10-06T16:11:27Z2019-10-06T16:11:27Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/14786419.2018.1537276Natural Product Research.1478-64271478-6419http://hdl.handle.net/11449/18853910.1080/14786419.2018.15372762-s2.0-85059016868Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNatural Product Researchinfo:eu-repo/semantics/openAccess2021-10-22T12:11:11Zoai:repositorio.unesp.br:11449/188539Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-22T12:11:11Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
In vitro inhibition of protein glycation and advanced glycation end products formation by hydroethanolic extract and two fractions of Simaba trichilioides roots |
title |
In vitro inhibition of protein glycation and advanced glycation end products formation by hydroethanolic extract and two fractions of Simaba trichilioides roots |
spellingShingle |
In vitro inhibition of protein glycation and advanced glycation end products formation by hydroethanolic extract and two fractions of Simaba trichilioides roots Motta, Bruno Pereira [UNESP] antiglycation activity diabetes mellitus glycoxidative stress Simaba trichilioides A St.-Hill Simaroubaceae |
title_short |
In vitro inhibition of protein glycation and advanced glycation end products formation by hydroethanolic extract and two fractions of Simaba trichilioides roots |
title_full |
In vitro inhibition of protein glycation and advanced glycation end products formation by hydroethanolic extract and two fractions of Simaba trichilioides roots |
title_fullStr |
In vitro inhibition of protein glycation and advanced glycation end products formation by hydroethanolic extract and two fractions of Simaba trichilioides roots |
title_full_unstemmed |
In vitro inhibition of protein glycation and advanced glycation end products formation by hydroethanolic extract and two fractions of Simaba trichilioides roots |
title_sort |
In vitro inhibition of protein glycation and advanced glycation end products formation by hydroethanolic extract and two fractions of Simaba trichilioides roots |
author |
Motta, Bruno Pereira [UNESP] |
author_facet |
Motta, Bruno Pereira [UNESP] Kaga, Anderson Kiyoshi [UNESP] Oliveira, Juliana Oriel [UNESP] Inacio, Maiara Destro [UNESP] da Silva, Cledson Ferreira de Sousa Junior, Paulo Teixeira Brunetti, Iguatemy Lourenço [UNESP] Baviera, Amanda Martins [UNESP] |
author_role |
author |
author2 |
Kaga, Anderson Kiyoshi [UNESP] Oliveira, Juliana Oriel [UNESP] Inacio, Maiara Destro [UNESP] da Silva, Cledson Ferreira de Sousa Junior, Paulo Teixeira Brunetti, Iguatemy Lourenço [UNESP] Baviera, Amanda Martins [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Federal University of Mato Grosso |
dc.contributor.author.fl_str_mv |
Motta, Bruno Pereira [UNESP] Kaga, Anderson Kiyoshi [UNESP] Oliveira, Juliana Oriel [UNESP] Inacio, Maiara Destro [UNESP] da Silva, Cledson Ferreira de Sousa Junior, Paulo Teixeira Brunetti, Iguatemy Lourenço [UNESP] Baviera, Amanda Martins [UNESP] |
dc.subject.por.fl_str_mv |
antiglycation activity diabetes mellitus glycoxidative stress Simaba trichilioides A St.-Hill Simaroubaceae |
topic |
antiglycation activity diabetes mellitus glycoxidative stress Simaba trichilioides A St.-Hill Simaroubaceae |
description |
Long-term hyperglycemia maintenance is responsible for increased protein glycation and formation of advanced glycation end products (AGEs), both are associated with the onset of diabetes mellitus complications. Efforts have been made to discover new agents having antiglycation potential. The aim of this study was to investigate the effects of the hydroethanolic extract and the ethyl acetate and methanolic fractions of Simaba trichilioides roots on the formation of AGEs. In an in vitro model system of protein glycation, incubations with hydroethanolic extract, ethyl acetate or methanolic fractions of S. trichilioides decreased the fluorescent AGEs, and markers of tyrosine and tryptophan oxidation. Protein crosslinking was reduced in the presence of the ethyl acetate fraction of S. trichilioides. Simaba trichilioides roots seem to be a promising source of compounds having ability to prevent glycoxidation changes, with potential applications in complementary therapies for management of diabetic complications. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 2019-10-06T16:11:27Z 2019-10-06T16:11:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/14786419.2018.1537276 Natural Product Research. 1478-6427 1478-6419 http://hdl.handle.net/11449/188539 10.1080/14786419.2018.1537276 2-s2.0-85059016868 |
url |
http://dx.doi.org/10.1080/14786419.2018.1537276 http://hdl.handle.net/11449/188539 |
identifier_str_mv |
Natural Product Research. 1478-6427 1478-6419 10.1080/14786419.2018.1537276 2-s2.0-85059016868 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Natural Product Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789262348812288 |