ABO blood groups and Helicobacter pylori cagA infection: evidence of an association

Detalhes bibliográficos
Autor(a) principal: Mattos, D. E. [UNESP]
Data de Publicação: 2010
Outros Autores: Cintra, J. R., Brandao de Mattos, C. C., Nakashima, F. [UNESP], Silva, R. C. M. A., Moreira, Haroldo Wilson [UNESP], de Mattos, L. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1678-91992010005000004
http://hdl.handle.net/11449/21514
Resumo: Diseases resulting from Helicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. of the samples, 66.4% (n = 73) tested positive and 33.6% (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0%) compared with chronic active gastritis (n = 52; 61.2%) (p = 0.05; OR 3.332; 95% CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2%) compared with other ABO phenotypes (25/47; 53.2%) (p = 0.01; OR 2.816; 95% CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers.
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spelling ABO blood groups and Helicobacter pylori cagA infection: evidence of an associationABO blood groupsH. pylori infectioncagA strainchronic active gastritispeptic ulcersDiseases resulting from Helicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. of the samples, 66.4% (n = 73) tested positive and 33.6% (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0%) compared with chronic active gastritis (n = 52; 61.2%) (p = 0.05; OR 3.332; 95% CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2%) compared with other ABO phenotypes (25/47; 53.2%) (p = 0.01; OR 2.816; 95% CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers.BAP/FAMERPCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Faculdade de Medicina de São José do Rio Preto (FAMERP), Dept Biol Mol, Lab Imunogenet, Sao Jose do Rio Preto Med Sch,FAMERP, BR-15090000 Sao Jose do Rio Preto, SP, BrazilFUNFARME, Reg Med Sch Fdn, Reg Blood Ctr Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, BrazilSão Paulo State Univ, UNESP, Sch Pharmaceut Sci, Clin Anal Dept, Araraquara, SP, BrazilSão Paulo State Univ, UNESP, Dept Biol, Inst Biosci Letters & Exact Sci, Sao Jose do Rio Preto, SP, BrazilFUNFARME, Base Hosp, Specialized Gastroenterol Lab, Sao Jose do Rio Preto, SP, BrazilSão Paulo State Univ, UNESP, Sch Pharmaceut Sci, Clin Anal Dept, Araraquara, SP, BrazilSão Paulo State Univ, UNESP, Dept Biol, Inst Biosci Letters & Exact Sci, Sao Jose do Rio Preto, SP, BrazilBAP/FAMERP: 4291/2007Universidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)Faculdade de Medicina de São José do Rio Preto (FAMERP)FUNFARMEUniversidade Estadual Paulista (Unesp)Mattos, D. E. [UNESP]Cintra, J. R.Brandao de Mattos, C. C.Nakashima, F. [UNESP]Silva, R. C. M. A.Moreira, Haroldo Wilson [UNESP]de Mattos, L. C.2014-05-20T14:00:54Z2014-05-20T14:00:54Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article87-95application/pdfhttp://dx.doi.org/10.1590/S1678-91992010005000004Journal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 16, n. 1, p. 87-95, 2010.1678-9199http://hdl.handle.net/11449/21514S1678-91992010000100009WOS:000276086200009S1678-91992010000100009-en.pdf9424175688206545Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseases1.7820,573info:eu-repo/semantics/openAccess2023-10-10T06:04:58Zoai:repositorio.unesp.br:11449/21514Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-10T06:04:58Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv ABO blood groups and Helicobacter pylori cagA infection: evidence of an association
title ABO blood groups and Helicobacter pylori cagA infection: evidence of an association
spellingShingle ABO blood groups and Helicobacter pylori cagA infection: evidence of an association
Mattos, D. E. [UNESP]
ABO blood groups
H. pylori infection
cagA strain
chronic active gastritis
peptic ulcers
title_short ABO blood groups and Helicobacter pylori cagA infection: evidence of an association
title_full ABO blood groups and Helicobacter pylori cagA infection: evidence of an association
title_fullStr ABO blood groups and Helicobacter pylori cagA infection: evidence of an association
title_full_unstemmed ABO blood groups and Helicobacter pylori cagA infection: evidence of an association
title_sort ABO blood groups and Helicobacter pylori cagA infection: evidence of an association
author Mattos, D. E. [UNESP]
author_facet Mattos, D. E. [UNESP]
Cintra, J. R.
Brandao de Mattos, C. C.
Nakashima, F. [UNESP]
Silva, R. C. M. A.
Moreira, Haroldo Wilson [UNESP]
de Mattos, L. C.
author_role author
author2 Cintra, J. R.
Brandao de Mattos, C. C.
Nakashima, F. [UNESP]
Silva, R. C. M. A.
Moreira, Haroldo Wilson [UNESP]
de Mattos, L. C.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Faculdade de Medicina de São José do Rio Preto (FAMERP)
FUNFARME
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Mattos, D. E. [UNESP]
Cintra, J. R.
Brandao de Mattos, C. C.
Nakashima, F. [UNESP]
Silva, R. C. M. A.
Moreira, Haroldo Wilson [UNESP]
de Mattos, L. C.
dc.subject.por.fl_str_mv ABO blood groups
H. pylori infection
cagA strain
chronic active gastritis
peptic ulcers
topic ABO blood groups
H. pylori infection
cagA strain
chronic active gastritis
peptic ulcers
description Diseases resulting from Helicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. of the samples, 66.4% (n = 73) tested positive and 33.6% (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0%) compared with chronic active gastritis (n = 52; 61.2%) (p = 0.05; OR 3.332; 95% CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2%) compared with other ABO phenotypes (25/47; 53.2%) (p = 0.01; OR 2.816; 95% CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
2014-05-20T14:00:54Z
2014-05-20T14:00:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1678-91992010005000004
Journal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 16, n. 1, p. 87-95, 2010.
1678-9199
http://hdl.handle.net/11449/21514
S1678-91992010000100009
WOS:000276086200009
S1678-91992010000100009-en.pdf
9424175688206545
url http://dx.doi.org/10.1590/S1678-91992010005000004
http://hdl.handle.net/11449/21514
identifier_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 16, n. 1, p. 87-95, 2010.
1678-9199
S1678-91992010000100009
WOS:000276086200009
S1678-91992010000100009-en.pdf
9424175688206545
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases
1.782
0,573
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 87-95
application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)
publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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