Metabolic profile and safety of piperlongumine
Main Author: | |
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Publication Date: | 2016 |
Other Authors: | , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.1038/srep33646 http://hdl.handle.net/11449/161967 |
Summary: | Piperlongumine (PPL), a natural plant product, has been extensively studied in cancer treatment going up on clinical trials. Since the first report related to its use on cancer research (in 2011) around 80 papers have been published in less than 10 years, but a gap still remaining. There are no metabolism studies of PPL in human organism. For the lack of a better view, here, the CYP450 in vitro oxidation of PPL was described for the first time. In addition, the enzymatic kinetic data, the predicted in vivo parameters, the produced metabolites, the phenotyping study and possible piperlongumine-drug interactions in vivo is presented. |
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Metabolic profile and safety of piperlonguminePiperlongumine (PPL), a natural plant product, has been extensively studied in cancer treatment going up on clinical trials. Since the first report related to its use on cancer research (in 2011) around 80 papers have been published in less than 10 years, but a gap still remaining. There are no metabolism studies of PPL in human organism. For the lack of a better view, here, the CYP450 in vitro oxidation of PPL was described for the first time. In addition, the enzymatic kinetic data, the predicted in vivo parameters, the produced metabolites, the phenotyping study and possible piperlongumine-drug interactions in vivo is presented.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)INCT-ifCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)University of Sao PauloUniv Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP, BrazilUniv Fed Rio de Janeiro, Lab Prod Bioat, Campus Macae IMMT, BR-27930560 Macae, RJ, BrazilSao Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, Nucleus Bioassays Biosynthesis & Ecophysiol Nat P, Araraquara, SP, BrazilUniv Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Nucleo Pesquisa Prod Nat & Sintet NPPNS, BR-14040903 Ribeirao Preto, SP, BrazilSao Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, Nucleus Bioassays Biosynthesis & Ecophysiol Nat P, Araraquara, SP, BrazilFAPESP: 2012/0188-4FAPESP: 2013/17658-9FAPESP: 2014/23604-1FAPESP: 2014/50265-3CNPq: 010143/2011-4CNPq: 442384/2014-9CNPq: 306385/2011-2University of Sao Paulo: 2012.1.17587.1.1Nature Publishing GroupUniversidade de São Paulo (USP)Universidade Federal do Rio de Janeiro (UFRJ)Universidade Estadual Paulista (Unesp)Moreira, Fernanda de LimaHabenschus, Maisa D.Barth, ThiagoMarques, Lucas M. M.Pilon, Alan Cesar [UNESP]Bolzani, Vanderlan da Silva [UNESP]Vessecchi, RicardoLopes, Norberto P.Oliveira, Anderson R. M. de2018-11-26T17:06:22Z2018-11-26T17:06:22Z2016-09-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://dx.doi.org/10.1038/srep33646Scientific Reports. London: Nature Publishing Group, v. 6, 9 p., 2016.2045-2322http://hdl.handle.net/11449/16196710.1038/srep33646WOS:000384173600001WOS000384173600001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScientific Reports1,533info:eu-repo/semantics/openAccess2024-01-04T06:28:19Zoai:repositorio.unesp.br:11449/161967Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-04T06:28:19Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Metabolic profile and safety of piperlongumine |
title |
Metabolic profile and safety of piperlongumine |
spellingShingle |
Metabolic profile and safety of piperlongumine Moreira, Fernanda de Lima |
title_short |
Metabolic profile and safety of piperlongumine |
title_full |
Metabolic profile and safety of piperlongumine |
title_fullStr |
Metabolic profile and safety of piperlongumine |
title_full_unstemmed |
Metabolic profile and safety of piperlongumine |
title_sort |
Metabolic profile and safety of piperlongumine |
author |
Moreira, Fernanda de Lima |
author_facet |
Moreira, Fernanda de Lima Habenschus, Maisa D. Barth, Thiago Marques, Lucas M. M. Pilon, Alan Cesar [UNESP] Bolzani, Vanderlan da Silva [UNESP] Vessecchi, Ricardo Lopes, Norberto P. Oliveira, Anderson R. M. de |
author_role |
author |
author2 |
Habenschus, Maisa D. Barth, Thiago Marques, Lucas M. M. Pilon, Alan Cesar [UNESP] Bolzani, Vanderlan da Silva [UNESP] Vessecchi, Ricardo Lopes, Norberto P. Oliveira, Anderson R. M. de |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal do Rio de Janeiro (UFRJ) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Moreira, Fernanda de Lima Habenschus, Maisa D. Barth, Thiago Marques, Lucas M. M. Pilon, Alan Cesar [UNESP] Bolzani, Vanderlan da Silva [UNESP] Vessecchi, Ricardo Lopes, Norberto P. Oliveira, Anderson R. M. de |
description |
Piperlongumine (PPL), a natural plant product, has been extensively studied in cancer treatment going up on clinical trials. Since the first report related to its use on cancer research (in 2011) around 80 papers have been published in less than 10 years, but a gap still remaining. There are no metabolism studies of PPL in human organism. For the lack of a better view, here, the CYP450 in vitro oxidation of PPL was described for the first time. In addition, the enzymatic kinetic data, the predicted in vivo parameters, the produced metabolites, the phenotyping study and possible piperlongumine-drug interactions in vivo is presented. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-29 2018-11-26T17:06:22Z 2018-11-26T17:06:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1038/srep33646 Scientific Reports. London: Nature Publishing Group, v. 6, 9 p., 2016. 2045-2322 http://hdl.handle.net/11449/161967 10.1038/srep33646 WOS:000384173600001 WOS000384173600001.pdf |
url |
http://dx.doi.org/10.1038/srep33646 http://hdl.handle.net/11449/161967 |
identifier_str_mv |
Scientific Reports. London: Nature Publishing Group, v. 6, 9 p., 2016. 2045-2322 10.1038/srep33646 WOS:000384173600001 WOS000384173600001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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Scientific Reports 1,533 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1797790202782023680 |