Comparing the electrochemical degradation of the fluoroquinolone antibiotics norfloxacin and ciprofloxacin using distinct electrolytes and a BDD anode: evolution of main oxidation byproducts and toxicity
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jece.2020.104433 http://hdl.handle.net/11449/209801 |
Resumo: | The effects of the supporting electrolytes (SEs) Na2SO4, NaCl, Na2CO3, NaNO3, and Na3PO4 on the anodic oxidation of norfloxacin (NOR) and ciprofloxacin (CIPRO), assessed by the respective degradation kinetics and byproducts and electrolyzed solution antimicrobial activity, are compared. Galvanostatic anodic oxidations were performed in a filter-press flow cell fitted with a boron-doped diamond anode. Removal rates higher than the theoretical one for a process purely controlled by mass transfer were found for all SEs, indicative of contribution by indirect oxidation processes. However, the removal rates for NaCl were about tenfold higher, with the lowest energy consumption per order (ECO) of targeted pollutant removal rate (ca. 0.7 kW h m(-3) order(-1)), a very competitive performance. The TOC removal rates were also affected by the SE, but not as markedly. The antimicrobial activity of the electrolyzed solutions against Escherichia coli showed distinct temporal profiles, depending on the fluoroquinolone and SE. For instance, when Na3PO4 was used, the antimicrobial activity was completely removed for NOR, but none for CIPRO; conversely, when NaCl was used, complete removal was attained only for CIPRO. From LC-MS/MS analyses of Na3PO4 electrolyzed solutions, rupture of the fluoroquinolone ring leading to byproducts with no toxicity against E. coli occurred only for NOR, whereas exactly the opposite occurred for the NaCl solutions. Clearly, the nature of both the SE and the fluoroquinolone influence the oxidation steps of the respective molecule; this was also evidenced by the distinct short-chain carboxylic acids identified in the degradation of NOR and CIPRO. |
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Comparing the electrochemical degradation of the fluoroquinolone antibiotics norfloxacin and ciprofloxacin using distinct electrolytes and a BDD anode: evolution of main oxidation byproducts and toxicityFluoroquinolone electrooxidationBoron-doped diamond anodeAnodic oxidationIndirect mediated oxidationAntimicrobial activity against E. coliElectrooxidation byproductsThe effects of the supporting electrolytes (SEs) Na2SO4, NaCl, Na2CO3, NaNO3, and Na3PO4 on the anodic oxidation of norfloxacin (NOR) and ciprofloxacin (CIPRO), assessed by the respective degradation kinetics and byproducts and electrolyzed solution antimicrobial activity, are compared. Galvanostatic anodic oxidations were performed in a filter-press flow cell fitted with a boron-doped diamond anode. Removal rates higher than the theoretical one for a process purely controlled by mass transfer were found for all SEs, indicative of contribution by indirect oxidation processes. However, the removal rates for NaCl were about tenfold higher, with the lowest energy consumption per order (ECO) of targeted pollutant removal rate (ca. 0.7 kW h m(-3) order(-1)), a very competitive performance. The TOC removal rates were also affected by the SE, but not as markedly. The antimicrobial activity of the electrolyzed solutions against Escherichia coli showed distinct temporal profiles, depending on the fluoroquinolone and SE. For instance, when Na3PO4 was used, the antimicrobial activity was completely removed for NOR, but none for CIPRO; conversely, when NaCl was used, complete removal was attained only for CIPRO. From LC-MS/MS analyses of Na3PO4 electrolyzed solutions, rupture of the fluoroquinolone ring leading to byproducts with no toxicity against E. coli occurred only for NOR, whereas exactly the opposite occurred for the NaCl solutions. Clearly, the nature of both the SE and the fluoroquinolone influence the oxidation steps of the respective molecule; this was also evidenced by the distinct short-chain carboxylic acids identified in the degradation of NOR and CIPRO.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP, BrazilUniv Estadual Paulista, Dept Quim Analit, Inst Quim Araraquara, BR-14800900 Araraquara, SP, BrazilUniv Fed Sao Carlos, Dept Engn Quim, CP 676, BR-13560970 Sao Carlos, SP, BrazilUniv Florida, Coll Vet Med, Dept Physiol Sci, Basic Sci Bldg,BSB 332,333 Ctr Dr, Gainesville, FL 32610 USAUniv Estadual Paulista, Dept Quim Analit, Inst Quim Araraquara, BR-14800900 Araraquara, SP, BrazilCNPq: 487270/2012-6CNPq: 311970/2017-6CAPES: 001FAPESP: 2008/10449-7Elsevier B.V.Universidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (Unesp)Univ FloridaCarneiro, Jussara F.Aquino, Jose M.Silva, Bianca F. [UNESP]Silva, Adilson J.Rocha-Filho, Romeu C.2021-06-25T12:29:43Z2021-06-25T12:29:43Z2020-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10http://dx.doi.org/10.1016/j.jece.2020.104433Journal Of Environmental Chemical Engineering. Oxford: Elsevier Sci Ltd, v. 8, n. 6, 10 p., 2020.http://hdl.handle.net/11449/20980110.1016/j.jece.2020.104433WOS:000600405700002Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Environmental Chemical Engineeringinfo:eu-repo/semantics/openAccess2021-10-23T19:50:02Zoai:repositorio.unesp.br:11449/209801Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T19:50:02Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Comparing the electrochemical degradation of the fluoroquinolone antibiotics norfloxacin and ciprofloxacin using distinct electrolytes and a BDD anode: evolution of main oxidation byproducts and toxicity |
title |
Comparing the electrochemical degradation of the fluoroquinolone antibiotics norfloxacin and ciprofloxacin using distinct electrolytes and a BDD anode: evolution of main oxidation byproducts and toxicity |
spellingShingle |
Comparing the electrochemical degradation of the fluoroquinolone antibiotics norfloxacin and ciprofloxacin using distinct electrolytes and a BDD anode: evolution of main oxidation byproducts and toxicity Carneiro, Jussara F. Fluoroquinolone electrooxidation Boron-doped diamond anode Anodic oxidation Indirect mediated oxidation Antimicrobial activity against E. coli Electrooxidation byproducts |
title_short |
Comparing the electrochemical degradation of the fluoroquinolone antibiotics norfloxacin and ciprofloxacin using distinct electrolytes and a BDD anode: evolution of main oxidation byproducts and toxicity |
title_full |
Comparing the electrochemical degradation of the fluoroquinolone antibiotics norfloxacin and ciprofloxacin using distinct electrolytes and a BDD anode: evolution of main oxidation byproducts and toxicity |
title_fullStr |
Comparing the electrochemical degradation of the fluoroquinolone antibiotics norfloxacin and ciprofloxacin using distinct electrolytes and a BDD anode: evolution of main oxidation byproducts and toxicity |
title_full_unstemmed |
Comparing the electrochemical degradation of the fluoroquinolone antibiotics norfloxacin and ciprofloxacin using distinct electrolytes and a BDD anode: evolution of main oxidation byproducts and toxicity |
title_sort |
Comparing the electrochemical degradation of the fluoroquinolone antibiotics norfloxacin and ciprofloxacin using distinct electrolytes and a BDD anode: evolution of main oxidation byproducts and toxicity |
author |
Carneiro, Jussara F. |
author_facet |
Carneiro, Jussara F. Aquino, Jose M. Silva, Bianca F. [UNESP] Silva, Adilson J. Rocha-Filho, Romeu C. |
author_role |
author |
author2 |
Aquino, Jose M. Silva, Bianca F. [UNESP] Silva, Adilson J. Rocha-Filho, Romeu C. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Carlos (UFSCar) Universidade Estadual Paulista (Unesp) Univ Florida |
dc.contributor.author.fl_str_mv |
Carneiro, Jussara F. Aquino, Jose M. Silva, Bianca F. [UNESP] Silva, Adilson J. Rocha-Filho, Romeu C. |
dc.subject.por.fl_str_mv |
Fluoroquinolone electrooxidation Boron-doped diamond anode Anodic oxidation Indirect mediated oxidation Antimicrobial activity against E. coli Electrooxidation byproducts |
topic |
Fluoroquinolone electrooxidation Boron-doped diamond anode Anodic oxidation Indirect mediated oxidation Antimicrobial activity against E. coli Electrooxidation byproducts |
description |
The effects of the supporting electrolytes (SEs) Na2SO4, NaCl, Na2CO3, NaNO3, and Na3PO4 on the anodic oxidation of norfloxacin (NOR) and ciprofloxacin (CIPRO), assessed by the respective degradation kinetics and byproducts and electrolyzed solution antimicrobial activity, are compared. Galvanostatic anodic oxidations were performed in a filter-press flow cell fitted with a boron-doped diamond anode. Removal rates higher than the theoretical one for a process purely controlled by mass transfer were found for all SEs, indicative of contribution by indirect oxidation processes. However, the removal rates for NaCl were about tenfold higher, with the lowest energy consumption per order (ECO) of targeted pollutant removal rate (ca. 0.7 kW h m(-3) order(-1)), a very competitive performance. The TOC removal rates were also affected by the SE, but not as markedly. The antimicrobial activity of the electrolyzed solutions against Escherichia coli showed distinct temporal profiles, depending on the fluoroquinolone and SE. For instance, when Na3PO4 was used, the antimicrobial activity was completely removed for NOR, but none for CIPRO; conversely, when NaCl was used, complete removal was attained only for CIPRO. From LC-MS/MS analyses of Na3PO4 electrolyzed solutions, rupture of the fluoroquinolone ring leading to byproducts with no toxicity against E. coli occurred only for NOR, whereas exactly the opposite occurred for the NaCl solutions. Clearly, the nature of both the SE and the fluoroquinolone influence the oxidation steps of the respective molecule; this was also evidenced by the distinct short-chain carboxylic acids identified in the degradation of NOR and CIPRO. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-01 2021-06-25T12:29:43Z 2021-06-25T12:29:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jece.2020.104433 Journal Of Environmental Chemical Engineering. Oxford: Elsevier Sci Ltd, v. 8, n. 6, 10 p., 2020. http://hdl.handle.net/11449/209801 10.1016/j.jece.2020.104433 WOS:000600405700002 |
url |
http://dx.doi.org/10.1016/j.jece.2020.104433 http://hdl.handle.net/11449/209801 |
identifier_str_mv |
Journal Of Environmental Chemical Engineering. Oxford: Elsevier Sci Ltd, v. 8, n. 6, 10 p., 2020. 10.1016/j.jece.2020.104433 WOS:000600405700002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Environmental Chemical Engineering |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
10 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789502855446528 |