Case for diagnosis. Erythroderma as manifestation of hypereosinophilic syndrome

• Autor(a) principal: Merlotto, Maira Renata [UNESP]
• Data de Publicação: 2018
• Outros Autores: Cantadori, Lucas Oliveira [UNESP], Sakabe, Delmo, Miot, Hélio Amante [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/abd1806-4841.20187419; http://hdl.handle.net/11449/176483
• topic: Dermatitis; Eosinophilia; Exfoliative; Polyneuropathies

Hypereosinophilic syndrome is defined as persistent eosinophilia (>1500/µL for more than six months) associated with organ involvement, excluding secondary causes. It is a rare, potentially lethal disease that should be considered in cutaneous conditions associated with hypereosinophilia. We report a case of erythroderma as a manifestation of hypereosinophilic syndrome. A 36-year-old male with no comorbidities presented progressive erythroderma, pruritus, peripheral neuropathy, and eosinophilia in the previous seven months. No mutations were found in FIP1L1/PDGFRA. Patient experienced rapid remission in response to oral prednisone and hydroxyurea. Cutaneous manifestations may be the only evidence of hypereosinophilic syndrome. Genotyping excludes myeloproliferative disease, thereby orienting treatment and prognosis.