Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trial
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.physbeh.2018.08.016 http://hdl.handle.net/11449/171414 |
Resumo: | This work evaluated the effects of moderate physical exercise performed under hypoxic conditions on melatonin and sleep. Forty healthy men were randomized into four groups: Normoxia (N) (n = 10); Hypoxia (H) (n = 10); Exercise under Normoxia (EN) (n = 10); and Exercise under Hypoxia (EH) (n = 10). The observation period for all groups was approximately 36 h, beginning with a first night devoid of any intervention. Aerobic exercise was performed by the EN and EH groups on a treadmill at 50% of the ventilatory threshold intensity for 60 min. Sleep evaluation was performed on the 1st and 2nd nights. Venous blood samples for the melatonin measurement were obtained on the 1st and 2nd days at 7:30 AM as well as on the 1st and 2nd nights at 10:30 PM. On the 2nd night, melatonin was higher in the H group than in the N group, but both were lower than values of the EH group. The nocturnal increase in melatonin was inversely correlated with the oxygen saturation of hemoglobin (SaO2%) on the 2nd night in the H group and on the 2nd day in the EH group. Diurnal remission of nocturnal melatonin appeared to be postponed in the H group and even more so in the EH group. Thus, normobaric hypoxia, which is equivalent to oxygen availability at an altitude of 4500 m, acutely increases melatonin. Moreover, diurnal remission of the nocturnal increase in melatonin seems to be delayed by hypoxia alone but even more so when acting together with exercise. |
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Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trialExerciseHypoxiaMelatoninThis work evaluated the effects of moderate physical exercise performed under hypoxic conditions on melatonin and sleep. Forty healthy men were randomized into four groups: Normoxia (N) (n = 10); Hypoxia (H) (n = 10); Exercise under Normoxia (EN) (n = 10); and Exercise under Hypoxia (EH) (n = 10). The observation period for all groups was approximately 36 h, beginning with a first night devoid of any intervention. Aerobic exercise was performed by the EN and EH groups on a treadmill at 50% of the ventilatory threshold intensity for 60 min. Sleep evaluation was performed on the 1st and 2nd nights. Venous blood samples for the melatonin measurement were obtained on the 1st and 2nd days at 7:30 AM as well as on the 1st and 2nd nights at 10:30 PM. On the 2nd night, melatonin was higher in the H group than in the N group, but both were lower than values of the EH group. The nocturnal increase in melatonin was inversely correlated with the oxygen saturation of hemoglobin (SaO2%) on the 2nd night in the H group and on the 2nd day in the EH group. Diurnal remission of nocturnal melatonin appeared to be postponed in the H group and even more so in the EH group. Thus, normobaric hypoxia, which is equivalent to oxygen availability at an altitude of 4500 m, acutely increases melatonin. Moreover, diurnal remission of the nocturnal increase in melatonin seems to be delayed by hypoxia alone but even more so when acting together with exercise.Department of Psychobiology Universidade Federal de São Paulo (UNIFESP)Department of Psychology Universidade Braz Cubas (UBC)Sports Department Universidade Federal de Minas Gerais (UFMG)Exercise and Immunometabolism Research Group Department of Physiology and Education Universidade do Estado de São Paulo (UNESP)Department of Biosciences Universidade Federal de São Paulo (UNIFESP)Program of Physiology and Biophysics ICBM Faculty of Medicine University of ChileGerencia Gestión del Conocimiento Mutual de Seguridad CChCDepartment of Physiology and Immunology University of BarcelonaExercise and Immunometabolism Research Group Department of Physiology and Education Universidade do Estado de São Paulo (UNESP)Universidade Federal de São Paulo (UNIFESP)Universidade Braz Cubas (UBC)Universidade Federal de Minas Gerais (UFMG)Universidade Estadual Paulista (Unesp)University of ChileCChCUniversity of Barcelonade Aquino Lemos, Valdirdos Santos, Ronaldo Vagner ThomatieliAntunes, Hanna Karen MoreiraBehn, ClausViscor, GinesLira, Fabio Santos [UNESP]Bittar, Irene Guarido LuzCaris, Aline VenticinqueTufik, SergioDe Mello, Marco Tulio2018-12-11T16:55:14Z2018-12-11T16:55:14Z2018-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article95-103application/pdfhttp://dx.doi.org/10.1016/j.physbeh.2018.08.016Physiology and Behavior, v. 196, p. 95-103.1873-507X0031-9384http://hdl.handle.net/11449/17141410.1016/j.physbeh.2018.08.0162-s2.0-850528595242-s2.0-85052859524.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhysiology and Behavior1,088info:eu-repo/semantics/openAccess2023-11-16T06:08:36Zoai:repositorio.unesp.br:11449/171414Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-16T06:08:36Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trial |
title |
Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trial |
spellingShingle |
Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trial de Aquino Lemos, Valdir Exercise Hypoxia Melatonin |
title_short |
Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trial |
title_full |
Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trial |
title_fullStr |
Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trial |
title_full_unstemmed |
Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trial |
title_sort |
Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trial |
author |
de Aquino Lemos, Valdir |
author_facet |
de Aquino Lemos, Valdir dos Santos, Ronaldo Vagner Thomatieli Antunes, Hanna Karen Moreira Behn, Claus Viscor, Gines Lira, Fabio Santos [UNESP] Bittar, Irene Guarido Luz Caris, Aline Venticinque Tufik, Sergio De Mello, Marco Tulio |
author_role |
author |
author2 |
dos Santos, Ronaldo Vagner Thomatieli Antunes, Hanna Karen Moreira Behn, Claus Viscor, Gines Lira, Fabio Santos [UNESP] Bittar, Irene Guarido Luz Caris, Aline Venticinque Tufik, Sergio De Mello, Marco Tulio |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Braz Cubas (UBC) Universidade Federal de Minas Gerais (UFMG) Universidade Estadual Paulista (Unesp) University of Chile CChC University of Barcelona |
dc.contributor.author.fl_str_mv |
de Aquino Lemos, Valdir dos Santos, Ronaldo Vagner Thomatieli Antunes, Hanna Karen Moreira Behn, Claus Viscor, Gines Lira, Fabio Santos [UNESP] Bittar, Irene Guarido Luz Caris, Aline Venticinque Tufik, Sergio De Mello, Marco Tulio |
dc.subject.por.fl_str_mv |
Exercise Hypoxia Melatonin |
topic |
Exercise Hypoxia Melatonin |
description |
This work evaluated the effects of moderate physical exercise performed under hypoxic conditions on melatonin and sleep. Forty healthy men were randomized into four groups: Normoxia (N) (n = 10); Hypoxia (H) (n = 10); Exercise under Normoxia (EN) (n = 10); and Exercise under Hypoxia (EH) (n = 10). The observation period for all groups was approximately 36 h, beginning with a first night devoid of any intervention. Aerobic exercise was performed by the EN and EH groups on a treadmill at 50% of the ventilatory threshold intensity for 60 min. Sleep evaluation was performed on the 1st and 2nd nights. Venous blood samples for the melatonin measurement were obtained on the 1st and 2nd days at 7:30 AM as well as on the 1st and 2nd nights at 10:30 PM. On the 2nd night, melatonin was higher in the H group than in the N group, but both were lower than values of the EH group. The nocturnal increase in melatonin was inversely correlated with the oxygen saturation of hemoglobin (SaO2%) on the 2nd night in the H group and on the 2nd day in the EH group. Diurnal remission of nocturnal melatonin appeared to be postponed in the H group and even more so in the EH group. Thus, normobaric hypoxia, which is equivalent to oxygen availability at an altitude of 4500 m, acutely increases melatonin. Moreover, diurnal remission of the nocturnal increase in melatonin seems to be delayed by hypoxia alone but even more so when acting together with exercise. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T16:55:14Z 2018-12-11T16:55:14Z 2018-11-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.physbeh.2018.08.016 Physiology and Behavior, v. 196, p. 95-103. 1873-507X 0031-9384 http://hdl.handle.net/11449/171414 10.1016/j.physbeh.2018.08.016 2-s2.0-85052859524 2-s2.0-85052859524.pdf |
url |
http://dx.doi.org/10.1016/j.physbeh.2018.08.016 http://hdl.handle.net/11449/171414 |
identifier_str_mv |
Physiology and Behavior, v. 196, p. 95-103. 1873-507X 0031-9384 10.1016/j.physbeh.2018.08.016 2-s2.0-85052859524 2-s2.0-85052859524.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Physiology and Behavior 1,088 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
95-103 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964952259198976 |