V-ATPases and Their Implication in Oral Cancer
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/978-3-319-24780-9_19 http://hdl.handle.net/11449/245377 |
Resumo: | The control of intracellular and extracellular pH is extremely important for many biological functions and the condition of hypoxia is a frequent phenomenon during the development of oral squamous cell carcinoma (OSCC). The cellular acidosis appears to be controlled, mainly, by the vacuolar-type H+ ATPase (V-ATPase), which is clearly involved in cellular transformation during carcinogenesis and metastasis. The C subunit (ATP6V1C) of V1 intra-membrane domain of the V-ATPase is primarily responsible for its enzymatic function, through the control of a reversible dissociation of VO and V1 domains. It is observed a high overexpression of the gene ATP6V1C 1 in OSCC, this tumor cells exhibited high metabolic activity and the active mechanisms capable of pumping protons from the cell interior are necessary. The acidification of the extracellular environment resulting from poor vascularization and cell metabolism promotes the activity of proteolytic enzymes that contribute to tumor invasiveness and metastasis. In the future, V-ATPase inhibitor molecules could be used in cancer treatment through the mensuration of the overexpression of specific V-ATPase subunits in tumors to be treated and, then, using specific inhibitors for the subunits being expressed. This will allow clinicians to provide more specific treatment, while also minimizing adverse effects. |
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V-ATPases and Their Implication in Oral CancerOral squamous cell carcinomaATP6V1C1CancerV-ATPase inhibitorsTumor metastasisChemoresistanceThe control of intracellular and extracellular pH is extremely important for many biological functions and the condition of hypoxia is a frequent phenomenon during the development of oral squamous cell carcinoma (OSCC). The cellular acidosis appears to be controlled, mainly, by the vacuolar-type H+ ATPase (V-ATPase), which is clearly involved in cellular transformation during carcinogenesis and metastasis. The C subunit (ATP6V1C) of V1 intra-membrane domain of the V-ATPase is primarily responsible for its enzymatic function, through the control of a reversible dissociation of VO and V1 domains. It is observed a high overexpression of the gene ATP6V1C 1 in OSCC, this tumor cells exhibited high metabolic activity and the active mechanisms capable of pumping protons from the cell interior are necessary. The acidification of the extracellular environment resulting from poor vascularization and cell metabolism promotes the activity of proteolytic enzymes that contribute to tumor invasiveness and metastasis. In the future, V-ATPase inhibitor molecules could be used in cancer treatment through the mensuration of the overexpression of specific V-ATPase subunits in tumors to be treated and, then, using specific inhibitors for the subunits being expressed. This will allow clinicians to provide more specific treatment, while also minimizing adverse effects.UNESP Univ Estadual Paulista, Dept Biosci & Oral Diag, Inst Sci & Technol, 777 Engn Francisco Jose Longo Ave, Sao Jose Dos Campos, SP, BrazilFac Med & Dent, Oral Med Oral Surg & Implantol Unit, Entrerrios S-N, Santiago De Compostela 15782, Acoruna, SpainUNESP Univ Estadual Paulista, Dept Biosci & Oral Diag, Inst Sci & Technol, 777 Engn Francisco Jose Longo Ave, Sao Jose Dos Campos, SP, BrazilSpringerUniversidade Estadual Paulista (UNESP)Fac Med & DentOliveira Alves, Monica Ghislaine [UNESP]Garcia-Garcia, AbelPerez-Sayans, MarioChakraborti, S.Dhalla, N. S.2023-07-29T11:53:06Z2023-07-29T11:53:06Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article393-405http://dx.doi.org/10.1007/978-3-319-24780-9_19Regulation of Ca2+-atpases, V-atpases and F-atpases. New York: Springer, v. 14, p. 393-405, 2016.http://hdl.handle.net/11449/24537710.1007/978-3-319-24780-9_19WOS:000369377300020Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRegulation Of Ca2+-atpases, V-atpases And F-atpasesinfo:eu-repo/semantics/openAccess2023-07-29T11:53:06Zoai:repositorio.unesp.br:11449/245377Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T11:53:06Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
V-ATPases and Their Implication in Oral Cancer |
title |
V-ATPases and Their Implication in Oral Cancer |
spellingShingle |
V-ATPases and Their Implication in Oral Cancer Oliveira Alves, Monica Ghislaine [UNESP] Oral squamous cell carcinoma ATP6V1C1 Cancer V-ATPase inhibitors Tumor metastasis Chemoresistance |
title_short |
V-ATPases and Their Implication in Oral Cancer |
title_full |
V-ATPases and Their Implication in Oral Cancer |
title_fullStr |
V-ATPases and Their Implication in Oral Cancer |
title_full_unstemmed |
V-ATPases and Their Implication in Oral Cancer |
title_sort |
V-ATPases and Their Implication in Oral Cancer |
author |
Oliveira Alves, Monica Ghislaine [UNESP] |
author_facet |
Oliveira Alves, Monica Ghislaine [UNESP] Garcia-Garcia, Abel Perez-Sayans, Mario Chakraborti, S. Dhalla, N. S. |
author_role |
author |
author2 |
Garcia-Garcia, Abel Perez-Sayans, Mario Chakraborti, S. Dhalla, N. S. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Fac Med & Dent |
dc.contributor.author.fl_str_mv |
Oliveira Alves, Monica Ghislaine [UNESP] Garcia-Garcia, Abel Perez-Sayans, Mario Chakraborti, S. Dhalla, N. S. |
dc.subject.por.fl_str_mv |
Oral squamous cell carcinoma ATP6V1C1 Cancer V-ATPase inhibitors Tumor metastasis Chemoresistance |
topic |
Oral squamous cell carcinoma ATP6V1C1 Cancer V-ATPase inhibitors Tumor metastasis Chemoresistance |
description |
The control of intracellular and extracellular pH is extremely important for many biological functions and the condition of hypoxia is a frequent phenomenon during the development of oral squamous cell carcinoma (OSCC). The cellular acidosis appears to be controlled, mainly, by the vacuolar-type H+ ATPase (V-ATPase), which is clearly involved in cellular transformation during carcinogenesis and metastasis. The C subunit (ATP6V1C) of V1 intra-membrane domain of the V-ATPase is primarily responsible for its enzymatic function, through the control of a reversible dissociation of VO and V1 domains. It is observed a high overexpression of the gene ATP6V1C 1 in OSCC, this tumor cells exhibited high metabolic activity and the active mechanisms capable of pumping protons from the cell interior are necessary. The acidification of the extracellular environment resulting from poor vascularization and cell metabolism promotes the activity of proteolytic enzymes that contribute to tumor invasiveness and metastasis. In the future, V-ATPase inhibitor molecules could be used in cancer treatment through the mensuration of the overexpression of specific V-ATPase subunits in tumors to be treated and, then, using specific inhibitors for the subunits being expressed. This will allow clinicians to provide more specific treatment, while also minimizing adverse effects. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 2023-07-29T11:53:06Z 2023-07-29T11:53:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/978-3-319-24780-9_19 Regulation of Ca2+-atpases, V-atpases and F-atpases. New York: Springer, v. 14, p. 393-405, 2016. http://hdl.handle.net/11449/245377 10.1007/978-3-319-24780-9_19 WOS:000369377300020 |
url |
http://dx.doi.org/10.1007/978-3-319-24780-9_19 http://hdl.handle.net/11449/245377 |
identifier_str_mv |
Regulation of Ca2+-atpases, V-atpases and F-atpases. New York: Springer, v. 14, p. 393-405, 2016. 10.1007/978-3-319-24780-9_19 WOS:000369377300020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Regulation Of Ca2+-atpases, V-atpases And F-atpases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
393-405 |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964677928648704 |