Dereplication of phenolic derivatives of qualea grandiflora and qualea cordata (vochysiaceae) using liquid chromatography coupled with ESI-QToF-MS/MS
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.5935/0103-5053.20130098 http://hdl.handle.net/11449/75692 |
Resumo: | A rational and selective method using on-line high-performance liquid chromatography (HPLC) coupled with electrospray quadrupole time-of-flight tandem mass spectrometry (ESI-QToF-MS/MS) was established for the dereplication of phenolic derivatives from Qualea grandiflora and Qualea cordata. The selection of the extracts was based on the antioxidant capacity measured by in vitro DPPH assay. The HPLC-ESI-QToF-MS/MS analysis was conducted by on-flow detection, using high-resolution mass/ratio ions as well as collision induced MS/MS experiments for selected protonated ions. The dereplication of the EtOAc fraction from the hydro alcohol extract from the stem bark of Q. grandiflora allowed the detection of the flavonoids: 3',4',5',5,6,7-hexahydroxy- 8 methylflavanone, 8-methyl-naringenine and 3',7-dimethoxy-8 methyl-4',5,7- trihydroxyflavanone, as well as a benzophenone derivatives: bis(4,6-dimethoxy-2- hydroxy-3-methylphenyl)- metanone, 3',4'-dimethoxy-8-methyl-5,6,7 trihydroxyflavanone, 7-methoxy-6-methyl- 3',4',5 trihydroxyflavanone, 6,8-dimethyl-3' methoxy-4',5,7 trihydroxyflavanone and 3',5'-dimethoxy-6,8- dimethyl-4',5,7 trihydroxyflavanone were detected in the EtOAc fraction from the hydro-alcohol extract from the leaves of Q. cordata. © 2013 Sociedade Brasileira de Química. |
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Repositório Institucional da UNESP |
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Dereplication of phenolic derivatives of qualea grandiflora and qualea cordata (vochysiaceae) using liquid chromatography coupled with ESI-QToF-MS/MSDereplicationHPLC-ESI-QToF-MS/MSQualea cordataQualea grandifloraRadical scavenging activityA rational and selective method using on-line high-performance liquid chromatography (HPLC) coupled with electrospray quadrupole time-of-flight tandem mass spectrometry (ESI-QToF-MS/MS) was established for the dereplication of phenolic derivatives from Qualea grandiflora and Qualea cordata. The selection of the extracts was based on the antioxidant capacity measured by in vitro DPPH assay. The HPLC-ESI-QToF-MS/MS analysis was conducted by on-flow detection, using high-resolution mass/ratio ions as well as collision induced MS/MS experiments for selected protonated ions. The dereplication of the EtOAc fraction from the hydro alcohol extract from the stem bark of Q. grandiflora allowed the detection of the flavonoids: 3',4',5',5,6,7-hexahydroxy- 8 methylflavanone, 8-methyl-naringenine and 3',7-dimethoxy-8 methyl-4',5,7- trihydroxyflavanone, as well as a benzophenone derivatives: bis(4,6-dimethoxy-2- hydroxy-3-methylphenyl)- metanone, 3',4'-dimethoxy-8-methyl-5,6,7 trihydroxyflavanone, 7-methoxy-6-methyl- 3',4',5 trihydroxyflavanone, 6,8-dimethyl-3' methoxy-4',5,7 trihydroxyflavanone and 3',5'-dimethoxy-6,8- dimethyl-4',5,7 trihydroxyflavanone were detected in the EtOAc fraction from the hydro-alcohol extract from the leaves of Q. cordata. © 2013 Sociedade Brasileira de Química.Nucleus of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE) Institute of Chemistry São Paulo State University (UNESP), CP 355, 14801-970 Araraquara-SPNucleus of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE) Institute of Chemistry São Paulo State University (UNESP), CP 355, 14801-970 Araraquara-SPUniversidade Estadual Paulista (Unesp)Neto, Fausto Carnevale [UNESP]Siquitelli, Cristian D. [UNESP]Pilon, Alan C. [UNESP]Silva, Dulce H.S. [UNESP]Bolzani, Vanderlan da Silva [UNESP]Castro-Gamboa, Ian [UNESP]2014-05-27T11:29:46Z2014-05-27T11:29:46Z2013-06-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article758-764application/pdfhttp://dx.doi.org/10.5935/0103-5053.20130098Journal of the Brazilian Chemical Society, v. 24, n. 5, p. 758-764, 2013.0103-50531678-4790http://hdl.handle.net/11449/7569210.5935/0103-5053.20130098WOS:0003204682000072-s2.0-848790225562-s2.0-84879022556.pdf47020049042312480000-0002-1516-7765Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Society1.4440,3570,357info:eu-repo/semantics/openAccess2023-12-28T06:15:14Zoai:repositorio.unesp.br:11449/75692Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-28T06:15:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Dereplication of phenolic derivatives of qualea grandiflora and qualea cordata (vochysiaceae) using liquid chromatography coupled with ESI-QToF-MS/MS |
title |
Dereplication of phenolic derivatives of qualea grandiflora and qualea cordata (vochysiaceae) using liquid chromatography coupled with ESI-QToF-MS/MS |
spellingShingle |
Dereplication of phenolic derivatives of qualea grandiflora and qualea cordata (vochysiaceae) using liquid chromatography coupled with ESI-QToF-MS/MS Neto, Fausto Carnevale [UNESP] Dereplication HPLC-ESI-QToF-MS/MS Qualea cordata Qualea grandiflora Radical scavenging activity |
title_short |
Dereplication of phenolic derivatives of qualea grandiflora and qualea cordata (vochysiaceae) using liquid chromatography coupled with ESI-QToF-MS/MS |
title_full |
Dereplication of phenolic derivatives of qualea grandiflora and qualea cordata (vochysiaceae) using liquid chromatography coupled with ESI-QToF-MS/MS |
title_fullStr |
Dereplication of phenolic derivatives of qualea grandiflora and qualea cordata (vochysiaceae) using liquid chromatography coupled with ESI-QToF-MS/MS |
title_full_unstemmed |
Dereplication of phenolic derivatives of qualea grandiflora and qualea cordata (vochysiaceae) using liquid chromatography coupled with ESI-QToF-MS/MS |
title_sort |
Dereplication of phenolic derivatives of qualea grandiflora and qualea cordata (vochysiaceae) using liquid chromatography coupled with ESI-QToF-MS/MS |
author |
Neto, Fausto Carnevale [UNESP] |
author_facet |
Neto, Fausto Carnevale [UNESP] Siquitelli, Cristian D. [UNESP] Pilon, Alan C. [UNESP] Silva, Dulce H.S. [UNESP] Bolzani, Vanderlan da Silva [UNESP] Castro-Gamboa, Ian [UNESP] |
author_role |
author |
author2 |
Siquitelli, Cristian D. [UNESP] Pilon, Alan C. [UNESP] Silva, Dulce H.S. [UNESP] Bolzani, Vanderlan da Silva [UNESP] Castro-Gamboa, Ian [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Neto, Fausto Carnevale [UNESP] Siquitelli, Cristian D. [UNESP] Pilon, Alan C. [UNESP] Silva, Dulce H.S. [UNESP] Bolzani, Vanderlan da Silva [UNESP] Castro-Gamboa, Ian [UNESP] |
dc.subject.por.fl_str_mv |
Dereplication HPLC-ESI-QToF-MS/MS Qualea cordata Qualea grandiflora Radical scavenging activity |
topic |
Dereplication HPLC-ESI-QToF-MS/MS Qualea cordata Qualea grandiflora Radical scavenging activity |
description |
A rational and selective method using on-line high-performance liquid chromatography (HPLC) coupled with electrospray quadrupole time-of-flight tandem mass spectrometry (ESI-QToF-MS/MS) was established for the dereplication of phenolic derivatives from Qualea grandiflora and Qualea cordata. The selection of the extracts was based on the antioxidant capacity measured by in vitro DPPH assay. The HPLC-ESI-QToF-MS/MS analysis was conducted by on-flow detection, using high-resolution mass/ratio ions as well as collision induced MS/MS experiments for selected protonated ions. The dereplication of the EtOAc fraction from the hydro alcohol extract from the stem bark of Q. grandiflora allowed the detection of the flavonoids: 3',4',5',5,6,7-hexahydroxy- 8 methylflavanone, 8-methyl-naringenine and 3',7-dimethoxy-8 methyl-4',5,7- trihydroxyflavanone, as well as a benzophenone derivatives: bis(4,6-dimethoxy-2- hydroxy-3-methylphenyl)- metanone, 3',4'-dimethoxy-8-methyl-5,6,7 trihydroxyflavanone, 7-methoxy-6-methyl- 3',4',5 trihydroxyflavanone, 6,8-dimethyl-3' methoxy-4',5,7 trihydroxyflavanone and 3',5'-dimethoxy-6,8- dimethyl-4',5,7 trihydroxyflavanone were detected in the EtOAc fraction from the hydro-alcohol extract from the leaves of Q. cordata. © 2013 Sociedade Brasileira de Química. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06-20 2014-05-27T11:29:46Z 2014-05-27T11:29:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5935/0103-5053.20130098 Journal of the Brazilian Chemical Society, v. 24, n. 5, p. 758-764, 2013. 0103-5053 1678-4790 http://hdl.handle.net/11449/75692 10.5935/0103-5053.20130098 WOS:000320468200007 2-s2.0-84879022556 2-s2.0-84879022556.pdf 4702004904231248 0000-0002-1516-7765 |
url |
http://dx.doi.org/10.5935/0103-5053.20130098 http://hdl.handle.net/11449/75692 |
identifier_str_mv |
Journal of the Brazilian Chemical Society, v. 24, n. 5, p. 758-764, 2013. 0103-5053 1678-4790 10.5935/0103-5053.20130098 WOS:000320468200007 2-s2.0-84879022556 2-s2.0-84879022556.pdf 4702004904231248 0000-0002-1516-7765 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of the Brazilian Chemical Society 1.444 0,357 0,357 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
758-764 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965431244521472 |