Evaluation of the degradation of two bioabsorbable interference screws: an in-vivo study in sheep
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/acb370405 http://hdl.handle.net/11449/241262 |
Resumo: | Purpose: To evaluate in-vivo degradation of two bioabsorbable interference screws. Methods: Twenty-two crossbred Santa Inês ewes were used. A poly-DL-lactide (PDLLA) screw (70%/30%) was inserted in the right pelvic limb, and a PDLLA screw (70%) + β-tri-calcium phosphate (β-TCP) (30%) in the left pelvic limb. Animals were euthanized at one, four, seven and a half and 18 months after surgery. Plain radiography, computed tomography (CT), microCT, and histological analysis were accomplished. Results: PDLLA screw was hypodense at all evaluation moments, but with progressive density increase along the central axis, whereas PDLLA/β-TCP was initially hyperdense and progressively lost this characteristic. No adverse reactions were observed on histological evaluation. Conclusions: The inclusion of β-TCP favors screw degradation since the PDLLA/β-TCP screws evidenced a more intense degradation process than the PDLLA screws at the last evaluation. PDLLA screws showed higher bone production, evident around the screw thread, inside the lateral perforations, and in the central canal, whereas the PDLLA/β-TCP screws presented less bone tissue at the implantation site. |
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spelling |
Evaluation of the degradation of two bioabsorbable interference screws: an in-vivo study in sheepAbsorbable ImplantsBone ScrewsPolylactic Acid-Polyglycolic Acid CopolymerSheepPurpose: To evaluate in-vivo degradation of two bioabsorbable interference screws. Methods: Twenty-two crossbred Santa Inês ewes were used. A poly-DL-lactide (PDLLA) screw (70%/30%) was inserted in the right pelvic limb, and a PDLLA screw (70%) + β-tri-calcium phosphate (β-TCP) (30%) in the left pelvic limb. Animals were euthanized at one, four, seven and a half and 18 months after surgery. Plain radiography, computed tomography (CT), microCT, and histological analysis were accomplished. Results: PDLLA screw was hypodense at all evaluation moments, but with progressive density increase along the central axis, whereas PDLLA/β-TCP was initially hyperdense and progressively lost this characteristic. No adverse reactions were observed on histological evaluation. Conclusions: The inclusion of β-TCP favors screw degradation since the PDLLA/β-TCP screws evidenced a more intense degradation process than the PDLLA screws at the last evaluation. PDLLA screws showed higher bone production, evident around the screw thread, inside the lateral perforations, and in the central canal, whereas the PDLLA/β-TCP screws presented less bone tissue at the implantation site.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade de Marília Faculty of Veterinary Medicine Department of Veterinary Surgery and Anesthesiology, SPUniversidade Estadual Paulista “Júlio de Mesquita Filho” School of Veterinary Medicine and Animal Science Department of Veterinary Surgery and Animal Reproduction, SPUniversidade de São Paulo Bauru School of Dentistry Department of Biological Sciences, SPUniversidade de Marília Department of Agronomic Engineering, Marília, SPUniversidade de Marília Veterinary Medicine School, Marília, SPUniversidade Estadual Paulista “Júlio de Mesquita Filho” School of Veterinary Medicine and Animal Science Department of Veterinary Surgery and Animal Reproduction, SPCAPES: 001Faculty of Veterinary MedicineUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Universidade de MaríliaVeterinary Medicine SchoolScorsato, Paulo SérgioRahal, Sheila Canevese [UNESP]Cestari, Tania MaryMamprim, Maria Jaqueline [UNESP]Doiche, Danuta Pulz [UNESP]Teixeira, Daniel de BortoliSiqueira, Rafael Cerântola [UNESP]Felix, Marcílio2023-03-01T20:54:06Z2023-03-01T20:54:06Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/acb370405Acta Cirurgica Brasileira, v. 37, n. 4, 2022.1678-26740102-8650http://hdl.handle.net/11449/24126210.1590/acb3704052-s2.0-85133214443Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccess2023-03-01T20:54:06Zoai:repositorio.unesp.br:11449/241262Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-03-01T20:54:06Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of the degradation of two bioabsorbable interference screws: an in-vivo study in sheep |
title |
Evaluation of the degradation of two bioabsorbable interference screws: an in-vivo study in sheep |
spellingShingle |
Evaluation of the degradation of two bioabsorbable interference screws: an in-vivo study in sheep Scorsato, Paulo Sérgio Absorbable Implants Bone Screws Polylactic Acid-Polyglycolic Acid Copolymer Sheep |
title_short |
Evaluation of the degradation of two bioabsorbable interference screws: an in-vivo study in sheep |
title_full |
Evaluation of the degradation of two bioabsorbable interference screws: an in-vivo study in sheep |
title_fullStr |
Evaluation of the degradation of two bioabsorbable interference screws: an in-vivo study in sheep |
title_full_unstemmed |
Evaluation of the degradation of two bioabsorbable interference screws: an in-vivo study in sheep |
title_sort |
Evaluation of the degradation of two bioabsorbable interference screws: an in-vivo study in sheep |
author |
Scorsato, Paulo Sérgio |
author_facet |
Scorsato, Paulo Sérgio Rahal, Sheila Canevese [UNESP] Cestari, Tania Mary Mamprim, Maria Jaqueline [UNESP] Doiche, Danuta Pulz [UNESP] Teixeira, Daniel de Bortoli Siqueira, Rafael Cerântola [UNESP] Felix, Marcílio |
author_role |
author |
author2 |
Rahal, Sheila Canevese [UNESP] Cestari, Tania Mary Mamprim, Maria Jaqueline [UNESP] Doiche, Danuta Pulz [UNESP] Teixeira, Daniel de Bortoli Siqueira, Rafael Cerântola [UNESP] Felix, Marcílio |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Faculty of Veterinary Medicine Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) Universidade de Marília Veterinary Medicine School |
dc.contributor.author.fl_str_mv |
Scorsato, Paulo Sérgio Rahal, Sheila Canevese [UNESP] Cestari, Tania Mary Mamprim, Maria Jaqueline [UNESP] Doiche, Danuta Pulz [UNESP] Teixeira, Daniel de Bortoli Siqueira, Rafael Cerântola [UNESP] Felix, Marcílio |
dc.subject.por.fl_str_mv |
Absorbable Implants Bone Screws Polylactic Acid-Polyglycolic Acid Copolymer Sheep |
topic |
Absorbable Implants Bone Screws Polylactic Acid-Polyglycolic Acid Copolymer Sheep |
description |
Purpose: To evaluate in-vivo degradation of two bioabsorbable interference screws. Methods: Twenty-two crossbred Santa Inês ewes were used. A poly-DL-lactide (PDLLA) screw (70%/30%) was inserted in the right pelvic limb, and a PDLLA screw (70%) + β-tri-calcium phosphate (β-TCP) (30%) in the left pelvic limb. Animals were euthanized at one, four, seven and a half and 18 months after surgery. Plain radiography, computed tomography (CT), microCT, and histological analysis were accomplished. Results: PDLLA screw was hypodense at all evaluation moments, but with progressive density increase along the central axis, whereas PDLLA/β-TCP was initially hyperdense and progressively lost this characteristic. No adverse reactions were observed on histological evaluation. Conclusions: The inclusion of β-TCP favors screw degradation since the PDLLA/β-TCP screws evidenced a more intense degradation process than the PDLLA screws at the last evaluation. PDLLA screws showed higher bone production, evident around the screw thread, inside the lateral perforations, and in the central canal, whereas the PDLLA/β-TCP screws presented less bone tissue at the implantation site. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-03-01T20:54:06Z 2023-03-01T20:54:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/acb370405 Acta Cirurgica Brasileira, v. 37, n. 4, 2022. 1678-2674 0102-8650 http://hdl.handle.net/11449/241262 10.1590/acb370405 2-s2.0-85133214443 |
url |
http://dx.doi.org/10.1590/acb370405 http://hdl.handle.net/11449/241262 |
identifier_str_mv |
Acta Cirurgica Brasileira, v. 37, n. 4, 2022. 1678-2674 0102-8650 10.1590/acb370405 2-s2.0-85133214443 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Cirurgica Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964378138673152 |