Novel iron complexes with quinoxaline N-1,N-4-dioxide derivatives: synthesis, characterization and antimycobacterial activity
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo de conferência |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://hdl.handle.net/11449/197384 |
Resumo: | Three new iron complexes with 3-aminoquinoxaline-2-carbonitrile N-1, N-4-dioxide derivatives (L) with stoichiometries [Fe(L1)(2)], [Fe(L1)(3)] and [Fe(L2)(3)]center dot 5H(2)O were synthesized and characterized. Both ligands and complexes showed in vitro activity against Mycobacterium. tuberculosis H(37)Rv (ATCC 27294) (MIC=3.9 mu g/mL for [Fe(L1)(2)] and [Fe(L2)(3)]center dot 5H(2)O and 7.8 mu g/mL for [Fe(L1)(3)]) with low citotoxicity. Two of the three complexes presented better activity than the free ligands, demonstrating that metal coordination can favorably modify the profile of antimycobacterial activity of 3-aminoquinoxaline-2-carbonitrile N-1,N-4-dioxide derivatives. |
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Novel iron complexes with quinoxaline N-1,N-4-dioxide derivatives: synthesis, characterization and antimycobacterial activityM. tuberculosisquinoxaline N-1,N-4-dioxidesiron complexesThree new iron complexes with 3-aminoquinoxaline-2-carbonitrile N-1, N-4-dioxide derivatives (L) with stoichiometries [Fe(L1)(2)], [Fe(L1)(3)] and [Fe(L2)(3)]center dot 5H(2)O were synthesized and characterized. Both ligands and complexes showed in vitro activity against Mycobacterium. tuberculosis H(37)Rv (ATCC 27294) (MIC=3.9 mu g/mL for [Fe(L1)(2)] and [Fe(L2)(3)]center dot 5H(2)O and 7.8 mu g/mL for [Fe(L1)(3)]) with low citotoxicity. Two of the three complexes presented better activity than the free ligands, demonstrating that metal coordination can favorably modify the profile of antimycobacterial activity of 3-aminoquinoxaline-2-carbonitrile N-1,N-4-dioxide derivatives.CHLCCPEDECIBA QuimicaUniv Republica, Fac Quim, Catedra Quim Inorgan, Gral Flores 2124,CC 1157, Montevideo 11800, UruguayUniv Navarra, CIFA, Pamplona, SpainUnesp, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, BrazilUnesp, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, BrazilJohn Libbey EurotextUniv RepublicaUniv NavarraUniversidade Estadual Paulista (Unesp)Tarallo, M. BelenUrquiola, CarolinaMonge, AntonioPavan, Fernando R. [UNESP]Leite, Clarice Q. [UNESP]Torre, Maria H.Gambino, DinorahCollery, P.Maymard, ITheophanides, T.Khassanova, L.Collery, T.2020-12-10T22:01:40Z2020-12-10T22:01:40Z2008-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject867-+Metal Ions In Biology And Medicine, Vol 10. Montrouge: John Libbey Eurotext, v. 10, p. 867-+, 2008.1257-2535http://hdl.handle.net/11449/197384WOS:000258426900145Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMetal Ions In Biology And Medicine, Vol 10info:eu-repo/semantics/openAccess2021-10-23T11:43:35Zoai:repositorio.unesp.br:11449/197384Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T11:43:35Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Novel iron complexes with quinoxaline N-1,N-4-dioxide derivatives: synthesis, characterization and antimycobacterial activity |
| title |
Novel iron complexes with quinoxaline N-1,N-4-dioxide derivatives: synthesis, characterization and antimycobacterial activity |
| spellingShingle |
Novel iron complexes with quinoxaline N-1,N-4-dioxide derivatives: synthesis, characterization and antimycobacterial activity Tarallo, M. Belen M. tuberculosis quinoxaline N-1,N-4-dioxides iron complexes |
| title_short |
Novel iron complexes with quinoxaline N-1,N-4-dioxide derivatives: synthesis, characterization and antimycobacterial activity |
| title_full |
Novel iron complexes with quinoxaline N-1,N-4-dioxide derivatives: synthesis, characterization and antimycobacterial activity |
| title_fullStr |
Novel iron complexes with quinoxaline N-1,N-4-dioxide derivatives: synthesis, characterization and antimycobacterial activity |
| title_full_unstemmed |
Novel iron complexes with quinoxaline N-1,N-4-dioxide derivatives: synthesis, characterization and antimycobacterial activity |
| title_sort |
Novel iron complexes with quinoxaline N-1,N-4-dioxide derivatives: synthesis, characterization and antimycobacterial activity |
| author |
Tarallo, M. Belen |
| author_facet |
Tarallo, M. Belen Urquiola, Carolina Monge, Antonio Pavan, Fernando R. [UNESP] Leite, Clarice Q. [UNESP] Torre, Maria H. Gambino, Dinorah Collery, P. Maymard, I Theophanides, T. Khassanova, L. Collery, T. |
| author_role |
author |
| author2 |
Urquiola, Carolina Monge, Antonio Pavan, Fernando R. [UNESP] Leite, Clarice Q. [UNESP] Torre, Maria H. Gambino, Dinorah Collery, P. Maymard, I Theophanides, T. Khassanova, L. Collery, T. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Univ Republica Univ Navarra Universidade Estadual Paulista (Unesp) |
| dc.contributor.author.fl_str_mv |
Tarallo, M. Belen Urquiola, Carolina Monge, Antonio Pavan, Fernando R. [UNESP] Leite, Clarice Q. [UNESP] Torre, Maria H. Gambino, Dinorah Collery, P. Maymard, I Theophanides, T. Khassanova, L. Collery, T. |
| dc.subject.por.fl_str_mv |
M. tuberculosis quinoxaline N-1,N-4-dioxides iron complexes |
| topic |
M. tuberculosis quinoxaline N-1,N-4-dioxides iron complexes |
| description |
Three new iron complexes with 3-aminoquinoxaline-2-carbonitrile N-1, N-4-dioxide derivatives (L) with stoichiometries [Fe(L1)(2)], [Fe(L1)(3)] and [Fe(L2)(3)]center dot 5H(2)O were synthesized and characterized. Both ligands and complexes showed in vitro activity against Mycobacterium. tuberculosis H(37)Rv (ATCC 27294) (MIC=3.9 mu g/mL for [Fe(L1)(2)] and [Fe(L2)(3)]center dot 5H(2)O and 7.8 mu g/mL for [Fe(L1)(3)]) with low citotoxicity. Two of the three complexes presented better activity than the free ligands, demonstrating that metal coordination can favorably modify the profile of antimycobacterial activity of 3-aminoquinoxaline-2-carbonitrile N-1,N-4-dioxide derivatives. |
| publishDate |
2008 |
| dc.date.none.fl_str_mv |
2008-01-01 2020-12-10T22:01:40Z 2020-12-10T22:01:40Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
| format |
conferenceObject |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
Metal Ions In Biology And Medicine, Vol 10. Montrouge: John Libbey Eurotext, v. 10, p. 867-+, 2008. 1257-2535 http://hdl.handle.net/11449/197384 WOS:000258426900145 |
| identifier_str_mv |
Metal Ions In Biology And Medicine, Vol 10. Montrouge: John Libbey Eurotext, v. 10, p. 867-+, 2008. 1257-2535 WOS:000258426900145 |
| url |
http://hdl.handle.net/11449/197384 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Metal Ions In Biology And Medicine, Vol 10 |
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info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
867-+ |
| dc.publisher.none.fl_str_mv |
John Libbey Eurotext |
| publisher.none.fl_str_mv |
John Libbey Eurotext |
| dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1799965611615322112 |