Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin
Main Author: | |
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Publication Date: | 2012 |
Other Authors: | , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.1590/S1516-89132012000400007 http://hdl.handle.net/11449/19054 |
Summary: | The present study investigated the effect of supplementation of vitamin E on streptozotocin (STZ)-induced diabetic rats by measuring blood glucose, changes in body weight, food and water intake, lipid profile, serum urea and creatinine level, and antioxidant enzyme activity. Male Wistar rats were divided into four groups: control rats (GI); rats receiving vitamin E (GII); STZ-induced diabetic rats (GIII) and STZ-induced diabetic rats treated with vitamin E (GIV). Vitamin E reduced (p<0.05) blood glucose and urea, improved the lipid profile (decreased the serum levels of total cholesterol, LDL cholesterol, VLDL cholesterol and triacylglycerols, and increased HDL cholesterol) and increased total protein in STZ-induced diabetic rats (GIV). Vitamin prevented changes in the activity of SOD and GSH-Px and in the concentration of lipid hydroperoxide. These results suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats. |
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Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitaminvitamin Elipid profileoxidative stressSTZThe present study investigated the effect of supplementation of vitamin E on streptozotocin (STZ)-induced diabetic rats by measuring blood glucose, changes in body weight, food and water intake, lipid profile, serum urea and creatinine level, and antioxidant enzyme activity. Male Wistar rats were divided into four groups: control rats (GI); rats receiving vitamin E (GII); STZ-induced diabetic rats (GIII) and STZ-induced diabetic rats treated with vitamin E (GIV). Vitamin E reduced (p<0.05) blood glucose and urea, improved the lipid profile (decreased the serum levels of total cholesterol, LDL cholesterol, VLDL cholesterol and triacylglycerols, and increased HDL cholesterol) and increased total protein in STZ-induced diabetic rats (GIV). Vitamin prevented changes in the activity of SOD and GSH-Px and in the concentration of lipid hydroperoxide. These results suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal do Mato GrossoUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Química e BioquímicaUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Química e BioquímicaBrazilian Archives of Biology and TechnologyUniversidade Federal do Mato GrossoUniversidade Estadual Paulista (Unesp)Almeida, Danielle Ayr Tavares deBraga, Camila Pereira [UNESP]Novelli, Ethel Lourenzi Barbosa [UNESP]Fernandes, Ana Angélica Henrique [UNESP]2014-05-20T13:53:23Z2014-05-20T13:53:23Z2012-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article527-536application/pdfhttp://dx.doi.org/10.1590/S1516-89132012000400007Brazilian Archives of Biology and Technology. Brazilian Archives of Biology and Technology, v. 55, n. 4, p. 527-536, 2012.1516-8913http://hdl.handle.net/11449/1905410.1590/S1516-89132012000400007S1516-89132012000400007WOS:000307710200007S1516-89132012000400007.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Archives of Biology and Technology0.6760,281info:eu-repo/semantics/openAccess2023-10-06T06:07:07Zoai:repositorio.unesp.br:11449/19054Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-06T06:07:07Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin |
title |
Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin |
spellingShingle |
Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin Almeida, Danielle Ayr Tavares de vitamin E lipid profile oxidative stress STZ |
title_short |
Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin |
title_full |
Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin |
title_fullStr |
Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin |
title_full_unstemmed |
Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin |
title_sort |
Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin |
author |
Almeida, Danielle Ayr Tavares de |
author_facet |
Almeida, Danielle Ayr Tavares de Braga, Camila Pereira [UNESP] Novelli, Ethel Lourenzi Barbosa [UNESP] Fernandes, Ana Angélica Henrique [UNESP] |
author_role |
author |
author2 |
Braga, Camila Pereira [UNESP] Novelli, Ethel Lourenzi Barbosa [UNESP] Fernandes, Ana Angélica Henrique [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Mato Grosso Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Almeida, Danielle Ayr Tavares de Braga, Camila Pereira [UNESP] Novelli, Ethel Lourenzi Barbosa [UNESP] Fernandes, Ana Angélica Henrique [UNESP] |
dc.subject.por.fl_str_mv |
vitamin E lipid profile oxidative stress STZ |
topic |
vitamin E lipid profile oxidative stress STZ |
description |
The present study investigated the effect of supplementation of vitamin E on streptozotocin (STZ)-induced diabetic rats by measuring blood glucose, changes in body weight, food and water intake, lipid profile, serum urea and creatinine level, and antioxidant enzyme activity. Male Wistar rats were divided into four groups: control rats (GI); rats receiving vitamin E (GII); STZ-induced diabetic rats (GIII) and STZ-induced diabetic rats treated with vitamin E (GIV). Vitamin E reduced (p<0.05) blood glucose and urea, improved the lipid profile (decreased the serum levels of total cholesterol, LDL cholesterol, VLDL cholesterol and triacylglycerols, and increased HDL cholesterol) and increased total protein in STZ-induced diabetic rats (GIV). Vitamin prevented changes in the activity of SOD and GSH-Px and in the concentration of lipid hydroperoxide. These results suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-08-01 2014-05-20T13:53:23Z 2014-05-20T13:53:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1516-89132012000400007 Brazilian Archives of Biology and Technology. Brazilian Archives of Biology and Technology, v. 55, n. 4, p. 527-536, 2012. 1516-8913 http://hdl.handle.net/11449/19054 10.1590/S1516-89132012000400007 S1516-89132012000400007 WOS:000307710200007 S1516-89132012000400007.pdf |
url |
http://dx.doi.org/10.1590/S1516-89132012000400007 http://hdl.handle.net/11449/19054 |
identifier_str_mv |
Brazilian Archives of Biology and Technology. Brazilian Archives of Biology and Technology, v. 55, n. 4, p. 527-536, 2012. 1516-8913 10.1590/S1516-89132012000400007 S1516-89132012000400007 WOS:000307710200007 S1516-89132012000400007.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Archives of Biology and Technology 0.676 0,281 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
527-536 application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Archives of Biology and Technology |
publisher.none.fl_str_mv |
Brazilian Archives of Biology and Technology |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964458465886208 |