Infarto do miocárdio experimental em ratos: Análise do modelo

Detalhes bibliográficos
Autor(a) principal: Zornoff, Leonardo Antonio Mamede [UNESP]
Data de Publicação: 2009
Outros Autores: Paiva, Sergio Alberto Rupp de [UNESP], Minicucci, Marcos Ferreira [UNESP], Spadaro, Joel [UNESP]
Tipo de documento: Artigo
Idioma: spa
por
eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0066-782X2009001000018
http://hdl.handle.net/11449/71173
Resumo: One of the most often used strategies to study the physiopathological alterations caused by coronary occlusion is the use of the experimental infarction model in rats. Among other factors, this is due to the similarities in the physiopathological alterations that occur after the infarction in humans. One must consider, however, that this model has characteristics that can hinder the use as well as the interpretation of eventual outcomes. Thus, this review aims at analyzing the main characteristics of the experimental infarction model in rats, discussing the coronary occlusion technique, the consequences and the methods of morphological and functional assessment of the infarction and its clinical implications.
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spelling Infarto do miocárdio experimental em ratos: Análise do modeloExperimental myocardium infarction in rats: analysis of the modelAnimals, laboratoryCoronary occlusionMyocardial infarctionRatsanimal experimentanimal modelcontrolled studyheart failureheart infarctionheart sizeheart surgeryheart ventricle hypertrophymortalitymuscle cellnonhumanratreviewOne of the most often used strategies to study the physiopathological alterations caused by coronary occlusion is the use of the experimental infarction model in rats. Among other factors, this is due to the similarities in the physiopathological alterations that occur after the infarction in humans. One must consider, however, that this model has characteristics that can hinder the use as well as the interpretation of eventual outcomes. Thus, this review aims at analyzing the main characteristics of the experimental infarction model in rats, discussing the coronary occlusion technique, the consequences and the methods of morphological and functional assessment of the infarction and its clinical implications.Faculdade de Medicina de Botucatu Departamento de Clínica Médica, Rubião Jr, 18.618-000, Botucatu, SPFaculdade de Medicina de Botucatu Departamento de Clínica Médica, Rubião Jr, 18.618-000, Botucatu, SPUniversidade Estadual Paulista (Unesp)Zornoff, Leonardo Antonio Mamede [UNESP]Paiva, Sergio Alberto Rupp de [UNESP]Minicucci, Marcos Ferreira [UNESP]Spadaro, Joel [UNESP]2014-05-27T11:23:59Z2014-05-27T11:23:59Z2009-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1590/S0066-782X2009001000018Arquivos Brasileiros de Cardiologia, v. 93, n. 4, 2009.0066-782X1678-4170http://hdl.handle.net/11449/7117310.1590/S0066-782X2009001000018S0066-782X20090010000182-s2.0-734491387482-s2.0-779547014712-s2.0-73449138748.pdf50168390153945477438704034471673Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPspaporengArquivos Brasileiros de Cardiologia1.318info:eu-repo/semantics/openAccess2024-01-12T06:30:21Zoai:repositorio.unesp.br:11449/71173Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-12T06:30:21Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Infarto do miocárdio experimental em ratos: Análise do modelo
Experimental myocardium infarction in rats: analysis of the model
title Infarto do miocárdio experimental em ratos: Análise do modelo
spellingShingle Infarto do miocárdio experimental em ratos: Análise do modelo
Zornoff, Leonardo Antonio Mamede [UNESP]
Animals, laboratory
Coronary occlusion
Myocardial infarction
Rats
animal experiment
animal model
controlled study
heart failure
heart infarction
heart size
heart surgery
heart ventricle hypertrophy
mortality
muscle cell
nonhuman
rat
review
title_short Infarto do miocárdio experimental em ratos: Análise do modelo
title_full Infarto do miocárdio experimental em ratos: Análise do modelo
title_fullStr Infarto do miocárdio experimental em ratos: Análise do modelo
title_full_unstemmed Infarto do miocárdio experimental em ratos: Análise do modelo
title_sort Infarto do miocárdio experimental em ratos: Análise do modelo
author Zornoff, Leonardo Antonio Mamede [UNESP]
author_facet Zornoff, Leonardo Antonio Mamede [UNESP]
Paiva, Sergio Alberto Rupp de [UNESP]
Minicucci, Marcos Ferreira [UNESP]
Spadaro, Joel [UNESP]
author_role author
author2 Paiva, Sergio Alberto Rupp de [UNESP]
Minicucci, Marcos Ferreira [UNESP]
Spadaro, Joel [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Zornoff, Leonardo Antonio Mamede [UNESP]
Paiva, Sergio Alberto Rupp de [UNESP]
Minicucci, Marcos Ferreira [UNESP]
Spadaro, Joel [UNESP]
dc.subject.por.fl_str_mv Animals, laboratory
Coronary occlusion
Myocardial infarction
Rats
animal experiment
animal model
controlled study
heart failure
heart infarction
heart size
heart surgery
heart ventricle hypertrophy
mortality
muscle cell
nonhuman
rat
review
topic Animals, laboratory
Coronary occlusion
Myocardial infarction
Rats
animal experiment
animal model
controlled study
heart failure
heart infarction
heart size
heart surgery
heart ventricle hypertrophy
mortality
muscle cell
nonhuman
rat
review
description One of the most often used strategies to study the physiopathological alterations caused by coronary occlusion is the use of the experimental infarction model in rats. Among other factors, this is due to the similarities in the physiopathological alterations that occur after the infarction in humans. One must consider, however, that this model has characteristics that can hinder the use as well as the interpretation of eventual outcomes. Thus, this review aims at analyzing the main characteristics of the experimental infarction model in rats, discussing the coronary occlusion technique, the consequences and the methods of morphological and functional assessment of the infarction and its clinical implications.
publishDate 2009
dc.date.none.fl_str_mv 2009-10-01
2014-05-27T11:23:59Z
2014-05-27T11:23:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0066-782X2009001000018
Arquivos Brasileiros de Cardiologia, v. 93, n. 4, 2009.
0066-782X
1678-4170
http://hdl.handle.net/11449/71173
10.1590/S0066-782X2009001000018
S0066-782X2009001000018
2-s2.0-73449138748
2-s2.0-77954701471
2-s2.0-73449138748.pdf
5016839015394547
7438704034471673
url http://dx.doi.org/10.1590/S0066-782X2009001000018
http://hdl.handle.net/11449/71173
identifier_str_mv Arquivos Brasileiros de Cardiologia, v. 93, n. 4, 2009.
0066-782X
1678-4170
10.1590/S0066-782X2009001000018
S0066-782X2009001000018
2-s2.0-73449138748
2-s2.0-77954701471
2-s2.0-73449138748.pdf
5016839015394547
7438704034471673
dc.language.iso.fl_str_mv spa
por
eng
language spa
por
eng
dc.relation.none.fl_str_mv Arquivos Brasileiros de Cardiologia
1.318
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1792962324780285952

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