Anti-apoptotic effects of decyl gallate on the induction of apoptosis in A549 pneumocytes by Paracoccidioides brasiliensis gp43

• Autor(a) principal: Bernardi, Thais [UNESP]
• Data de Publicação: 2017
• Outros Autores: De Fátima Da Silva, Julhiany [UNESP], Vicentin, Juliana [UNESP], De Oliveira, Haroldo Cesar [UNESP], Assato, Patricia Akemi [UNESP], Marcos, Caroline Maria [UNESP], De Paula E Silva, Ana Carolina Alves [UNESP], Da Silva, Rosangela Aparecida Moraes [UNESP], Regasini, Luis Octávio [UNESP], Silva, Dulce Helena Siqueira [UNESP], Da Silva Bolzani, Vanderlan [UNESP], Fusco-Almeida, Ana Marisa [UNESP], Mendes-Giannini, Maria José Soares [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1093/mmy/myx013; http://hdl.handle.net/11449/175383
• topic: Apoptosis; Decyl gallate; Gp43; Paracoccidioides brasiliensis

Apoptosis is considered an escapemechanism from the host immune system for the fungus Paracoccidioides spp, and it serves as a vehicle for entry into macrophages without stimulating microbicidal activities. Recently, gp43 of P. brasiliensis was demonstrated to be involved in this process. Therefore, as a new therapeutic alternative, it is very important to study compounds that could reduce the modulation of the induction of apoptosis caused by this fungus. Decyl gallate (G14) is a known antifungal compound, and we decided to investigate its anti-apoptotic properties. Our results demonstrate that G14 was effective against apoptosis induced by gp43, as observed in epithelial cells, and led to a reduction in DNA damage, Bak down-regulation and Bcl-2 up-regulation. Together, these data show that G14 presents promising anti-apoptotic activity.