Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Moacyr Tadeu Vicente
Data de Publicação: 2011
Outros Autores: Cardoso, Camila Lopes, Carvalho, Paulo Sérgio Perri de, Cestari, Tânia Mary, Feres, Magda, Garlet, Gustavo Pompermaier, Ferreira Júnior, Osny
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/3906
Resumo: The pathogenesis of alveolitis is not well known and therefore experimental situations that mimic some features of this disease should be developed. OBJECTIVE: In this study, the evolution of the experimentally induced infection in rat sockets is characterized, which leads to clinical signs of suppurative alveolitis with remarkable wound healing disturbs. MATERIAL AND METHODS: Non-infected (Group I) and experimentally infected sockets in Rattus novergicus (Group II) were histometrically evaluated regarding the kinetics of alveolar healing. In addition, the characterization of the present bacteria in inoculation material and the serum levels of C-reactive protein (CRP) were performed. The detected species were Capnocytophaga ochracea, Fusobacterium nucleatum ss nucleatum, Prevotella melaninogenica, Streptococcus anginosus, Treponema socranskii and Streptococcus sanguis. RESULTS: All experimentally infected rats developed suppurative alveolitis, showing higher levels of CRP in comparison to those non-infected ones. Furthermore, infected rats presented a significant delayed wound healing as measured by the histometric analysis (higher persistent polymorphonuclear infiltrate and lower density of newly formed bone). CONCLUSION: These findings indicate that rat sockets with experimentally induced infection produced higher levels of serum CRP, showing the potential of disseminated infection and a disturb in the alveolar repair process in an interesting experimental model for alveolitis studies.
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spelling Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing Dry socketTooth extractionC-reactive proteinAlveolitis The pathogenesis of alveolitis is not well known and therefore experimental situations that mimic some features of this disease should be developed. OBJECTIVE: In this study, the evolution of the experimentally induced infection in rat sockets is characterized, which leads to clinical signs of suppurative alveolitis with remarkable wound healing disturbs. MATERIAL AND METHODS: Non-infected (Group I) and experimentally infected sockets in Rattus novergicus (Group II) were histometrically evaluated regarding the kinetics of alveolar healing. In addition, the characterization of the present bacteria in inoculation material and the serum levels of C-reactive protein (CRP) were performed. The detected species were Capnocytophaga ochracea, Fusobacterium nucleatum ss nucleatum, Prevotella melaninogenica, Streptococcus anginosus, Treponema socranskii and Streptococcus sanguis. RESULTS: All experimentally infected rats developed suppurative alveolitis, showing higher levels of CRP in comparison to those non-infected ones. Furthermore, infected rats presented a significant delayed wound healing as measured by the histometric analysis (higher persistent polymorphonuclear infiltrate and lower density of newly formed bone). CONCLUSION: These findings indicate that rat sockets with experimentally induced infection produced higher levels of serum CRP, showing the potential of disseminated infection and a disturb in the alveolar repair process in an interesting experimental model for alveolitis studies. Universidade de São Paulo. Faculdade de Odontologia de Bauru2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/390610.1590/S1678-77572011000300015Journal of Applied Oral Science; Vol. 19 No. 3 (2011); 260-268 Journal of Applied Oral Science; Vol. 19 Núm. 3 (2011); 260-268 Journal of Applied Oral Science; v. 19 n. 3 (2011); 260-268 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/3906/4596Copyright (c) 2011 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessRodrigues, Moacyr Tadeu VicenteCardoso, Camila LopesCarvalho, Paulo Sérgio Perri deCestari, Tânia MaryFeres, MagdaGarlet, Gustavo PompermaierFerreira Júnior, Osny2012-04-27T12:13:48Zoai:revistas.usp.br:article/3906Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-04-27T12:13:48Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing
title Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing
spellingShingle Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing
Rodrigues, Moacyr Tadeu Vicente
Dry socket
Tooth extraction
C-reactive protein
Alveolitis
title_short Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing
title_full Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing
title_fullStr Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing
title_full_unstemmed Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing
title_sort Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing
author Rodrigues, Moacyr Tadeu Vicente
author_facet Rodrigues, Moacyr Tadeu Vicente
Cardoso, Camila Lopes
Carvalho, Paulo Sérgio Perri de
Cestari, Tânia Mary
Feres, Magda
Garlet, Gustavo Pompermaier
Ferreira Júnior, Osny
author_role author
author2 Cardoso, Camila Lopes
Carvalho, Paulo Sérgio Perri de
Cestari, Tânia Mary
Feres, Magda
Garlet, Gustavo Pompermaier
Ferreira Júnior, Osny
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Moacyr Tadeu Vicente
Cardoso, Camila Lopes
Carvalho, Paulo Sérgio Perri de
Cestari, Tânia Mary
Feres, Magda
Garlet, Gustavo Pompermaier
Ferreira Júnior, Osny
dc.subject.por.fl_str_mv Dry socket
Tooth extraction
C-reactive protein
Alveolitis
topic Dry socket
Tooth extraction
C-reactive protein
Alveolitis
description The pathogenesis of alveolitis is not well known and therefore experimental situations that mimic some features of this disease should be developed. OBJECTIVE: In this study, the evolution of the experimentally induced infection in rat sockets is characterized, which leads to clinical signs of suppurative alveolitis with remarkable wound healing disturbs. MATERIAL AND METHODS: Non-infected (Group I) and experimentally infected sockets in Rattus novergicus (Group II) were histometrically evaluated regarding the kinetics of alveolar healing. In addition, the characterization of the present bacteria in inoculation material and the serum levels of C-reactive protein (CRP) were performed. The detected species were Capnocytophaga ochracea, Fusobacterium nucleatum ss nucleatum, Prevotella melaninogenica, Streptococcus anginosus, Treponema socranskii and Streptococcus sanguis. RESULTS: All experimentally infected rats developed suppurative alveolitis, showing higher levels of CRP in comparison to those non-infected ones. Furthermore, infected rats presented a significant delayed wound healing as measured by the histometric analysis (higher persistent polymorphonuclear infiltrate and lower density of newly formed bone). CONCLUSION: These findings indicate that rat sockets with experimentally induced infection produced higher levels of serum CRP, showing the potential of disseminated infection and a disturb in the alveolar repair process in an interesting experimental model for alveolitis studies.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3906
10.1590/S1678-77572011000300015
url https://www.revistas.usp.br/jaos/article/view/3906
identifier_str_mv 10.1590/S1678-77572011000300015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3906/4596
dc.rights.driver.fl_str_mv Copyright (c) 2011 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2011 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 19 No. 3 (2011); 260-268
Journal of Applied Oral Science; Vol. 19 Núm. 3 (2011); 260-268
Journal of Applied Oral Science; v. 19 n. 3 (2011); 260-268
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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