Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease

Detalhes bibliográficos
Autor(a) principal: Carneiro, Valéria Martins Araújo
Data de Publicação: 2012
Outros Autores: Bezerra, Ana Cristina Barreto, Guimarães, Maria do Carmo Machado, Muniz-Junqueira, Maria Imaculada
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/47981
Resumo: Phagocytosis by neutrophils and monocytes constitutes the main defense mechanism against bacterial challenges in periodontitis. Phagocytosis by neutrophils has already been evaluated, whereas phagocytic function of monocytes has hardly been addressed so far. Objectives: The aim of this study was to assess phagocytosis by neutrophils and monocytes in periodontitis. Material and Methods: The sample included 30 subjects with severe periodontitis and 27 control subjects without periodontal disease. The phagocytic index (PhI) was calculated as the mean number of adhered/ingested Saccharomyces cerevisiae per phagocytozing monocyte or neutrophil multiplied by the percentage of phagocytes involved in phagocytosis. Results: A significant reduction in phagocyte functions was observed in individuals with periodontitis. The median of PhI of neutrophils using nonsensitized S. cerevisiae was 3 for the control group, and 1.5 for the periodontitis group (p=0.01, Mann-Whitney test). The median of PhI of monocytes with non-sensitized S. cerevisiae was 26.13 for the control group, and 13.23 for the periodontitis group (p=0.03, Mann Whitney test). The median of PhI of monocytes assessed with sensitized S. cerevisiae was 97.92 for the control group and 60.1 for the periodontitis group (p=0.005, t-test). Conclusion: The data demonstrated a reduction in the function of phagocytes, suggesting a decrease in immune defenses in periodontitis.
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spelling Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal diseasePeriodontitisNeutrophilsMonocytesPhagocytosisPhagocytosis by neutrophils and monocytes constitutes the main defense mechanism against bacterial challenges in periodontitis. Phagocytosis by neutrophils has already been evaluated, whereas phagocytic function of monocytes has hardly been addressed so far. Objectives: The aim of this study was to assess phagocytosis by neutrophils and monocytes in periodontitis. Material and Methods: The sample included 30 subjects with severe periodontitis and 27 control subjects without periodontal disease. The phagocytic index (PhI) was calculated as the mean number of adhered/ingested Saccharomyces cerevisiae per phagocytozing monocyte or neutrophil multiplied by the percentage of phagocytes involved in phagocytosis. Results: A significant reduction in phagocyte functions was observed in individuals with periodontitis. The median of PhI of neutrophils using nonsensitized S. cerevisiae was 3 for the control group, and 1.5 for the periodontitis group (p=0.01, Mann-Whitney test). The median of PhI of monocytes with non-sensitized S. cerevisiae was 26.13 for the control group, and 13.23 for the periodontitis group (p=0.03, Mann Whitney test). The median of PhI of monocytes assessed with sensitized S. cerevisiae was 97.92 for the control group and 60.1 for the periodontitis group (p=0.005, t-test). Conclusion: The data demonstrated a reduction in the function of phagocytes, suggesting a decrease in immune defenses in periodontitis.Universidade de São Paulo. Faculdade de Odontologia de Bauru2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/4798110.1590/S1678-77572012000500002Journal of Applied Oral Science; Vol. 20 No. 5 (2012); 503-509Journal of Applied Oral Science; Vol. 20 Núm. 5 (2012); 503-509Journal of Applied Oral Science; v. 20 n. 5 (2012); 503-5091678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/47981/51721Copyright (c) 2012 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessCarneiro, Valéria Martins AraújoBezerra, Ana Cristina BarretoGuimarães, Maria do Carmo MachadoMuniz-Junqueira, Maria Imaculada2012-12-13T12:10:07Zoai:revistas.usp.br:article/47981Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-12-13T12:10:07Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease
title Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease
spellingShingle Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease
Carneiro, Valéria Martins Araújo
Periodontitis
Neutrophils
Monocytes
Phagocytosis
title_short Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease
title_full Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease
title_fullStr Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease
title_full_unstemmed Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease
title_sort Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease
author Carneiro, Valéria Martins Araújo
author_facet Carneiro, Valéria Martins Araújo
Bezerra, Ana Cristina Barreto
Guimarães, Maria do Carmo Machado
Muniz-Junqueira, Maria Imaculada
author_role author
author2 Bezerra, Ana Cristina Barreto
Guimarães, Maria do Carmo Machado
Muniz-Junqueira, Maria Imaculada
author2_role author
author
author
dc.contributor.author.fl_str_mv Carneiro, Valéria Martins Araújo
Bezerra, Ana Cristina Barreto
Guimarães, Maria do Carmo Machado
Muniz-Junqueira, Maria Imaculada
dc.subject.por.fl_str_mv Periodontitis
Neutrophils
Monocytes
Phagocytosis
topic Periodontitis
Neutrophils
Monocytes
Phagocytosis
description Phagocytosis by neutrophils and monocytes constitutes the main defense mechanism against bacterial challenges in periodontitis. Phagocytosis by neutrophils has already been evaluated, whereas phagocytic function of monocytes has hardly been addressed so far. Objectives: The aim of this study was to assess phagocytosis by neutrophils and monocytes in periodontitis. Material and Methods: The sample included 30 subjects with severe periodontitis and 27 control subjects without periodontal disease. The phagocytic index (PhI) was calculated as the mean number of adhered/ingested Saccharomyces cerevisiae per phagocytozing monocyte or neutrophil multiplied by the percentage of phagocytes involved in phagocytosis. Results: A significant reduction in phagocyte functions was observed in individuals with periodontitis. The median of PhI of neutrophils using nonsensitized S. cerevisiae was 3 for the control group, and 1.5 for the periodontitis group (p=0.01, Mann-Whitney test). The median of PhI of monocytes with non-sensitized S. cerevisiae was 26.13 for the control group, and 13.23 for the periodontitis group (p=0.03, Mann Whitney test). The median of PhI of monocytes assessed with sensitized S. cerevisiae was 97.92 for the control group and 60.1 for the periodontitis group (p=0.005, t-test). Conclusion: The data demonstrated a reduction in the function of phagocytes, suggesting a decrease in immune defenses in periodontitis.
publishDate 2012
dc.date.none.fl_str_mv 2012-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/47981
10.1590/S1678-77572012000500002
url https://www.revistas.usp.br/jaos/article/view/47981
identifier_str_mv 10.1590/S1678-77572012000500002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/47981/51721
dc.rights.driver.fl_str_mv Copyright (c) 2012 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2012 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 20 No. 5 (2012); 503-509
Journal of Applied Oral Science; Vol. 20 Núm. 5 (2012); 503-509
Journal of Applied Oral Science; v. 20 n. 5 (2012); 503-509
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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