Preventive effect of toothpastes with MMP inhibitors on human dentine erosion and abrasion in vitro
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572016000100061 |
Resumo: | ABSTRACT The use of gels and mouthrinses with MMP inhibitors (chlorhexidine, and green tea extract) was shown to prevent erosive wear. The aim of this study was to analyze the protective effect of toothpastes containing MMP inhibitors on dentine loss induced by erosion in vitro. Material and Methods Five groups each containing 12 specimens of human root dentine were prepared. The specimens were subjected to 1 min erosion by immersion in a cola drink, 4 times a day, for 5 d. Each day, after the first and last erosive challenges, the specimens were brushed for 15 s with a slurry of dentifrice and water (1:3) containing placebo, 1,100 ppm fluoride, 0.61% green tea extract, 0.12% chlorhexidine or 0.004% chlorhexidine (commercial toothpaste). Between the acid challenges, the specimens were stored in artificial saliva with remineralizing potential until the next treatment. Dentine loss was determined using profilometry. Data were analyzed using one-way ANOVA after log transform (p<0.05). Results The mean wear values (μm) were as follows: placebo 1.83±0.53; 0.61% green tea extract 1.00±0.21; fluoride 1.27±0.43; 0.12% chlorhexidine 1.19±0.30; and 0.004% chlorhexidine 1.22±0.46. There was a significant difference in wear between placebo and all the treatment toothpastes, which did not differ from each other. Conclusion The results suggest that toothpastes containing MMP inhibitors are as effective as those based on NaF in preventing dentine erosion and abrasion. |
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Journal of applied oral science (Online) |
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Preventive effect of toothpastes with MMP inhibitors on human dentine erosion and abrasion in vitroErosionDentinMatrix metalloproteinasesInhibitorsToothpastesABSTRACT The use of gels and mouthrinses with MMP inhibitors (chlorhexidine, and green tea extract) was shown to prevent erosive wear. The aim of this study was to analyze the protective effect of toothpastes containing MMP inhibitors on dentine loss induced by erosion in vitro. Material and Methods Five groups each containing 12 specimens of human root dentine were prepared. The specimens were subjected to 1 min erosion by immersion in a cola drink, 4 times a day, for 5 d. Each day, after the first and last erosive challenges, the specimens were brushed for 15 s with a slurry of dentifrice and water (1:3) containing placebo, 1,100 ppm fluoride, 0.61% green tea extract, 0.12% chlorhexidine or 0.004% chlorhexidine (commercial toothpaste). Between the acid challenges, the specimens were stored in artificial saliva with remineralizing potential until the next treatment. Dentine loss was determined using profilometry. Data were analyzed using one-way ANOVA after log transform (p<0.05). Results The mean wear values (μm) were as follows: placebo 1.83±0.53; 0.61% green tea extract 1.00±0.21; fluoride 1.27±0.43; 0.12% chlorhexidine 1.19±0.30; and 0.004% chlorhexidine 1.22±0.46. There was a significant difference in wear between placebo and all the treatment toothpastes, which did not differ from each other. Conclusion The results suggest that toothpastes containing MMP inhibitors are as effective as those based on NaF in preventing dentine erosion and abrasion.Faculdade De Odontologia De Bauru - USP2016-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572016000100061Journal of Applied Oral Science v.24 n.1 2016reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/1678-775720150289info:eu-repo/semantics/openAccessHannas,Angelica ReisKato,Melissa ThiemiCardoso,Cristiane de Almeida BaldiniMagalhães,Ana CarolinaPereira,José CarlosTjäderhane,LeoBuzalaf,Marília Afonso Rabeloeng2016-04-07T00:00:00Zoai:scielo:S1678-77572016000100061Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2016-04-07T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Preventive effect of toothpastes with MMP inhibitors on human dentine erosion and abrasion in vitro |
title |
Preventive effect of toothpastes with MMP inhibitors on human dentine erosion and abrasion in vitro |
spellingShingle |
Preventive effect of toothpastes with MMP inhibitors on human dentine erosion and abrasion in vitro Hannas,Angelica Reis Erosion Dentin Matrix metalloproteinases Inhibitors Toothpastes |
title_short |
Preventive effect of toothpastes with MMP inhibitors on human dentine erosion and abrasion in vitro |
title_full |
Preventive effect of toothpastes with MMP inhibitors on human dentine erosion and abrasion in vitro |
title_fullStr |
Preventive effect of toothpastes with MMP inhibitors on human dentine erosion and abrasion in vitro |
title_full_unstemmed |
Preventive effect of toothpastes with MMP inhibitors on human dentine erosion and abrasion in vitro |
title_sort |
Preventive effect of toothpastes with MMP inhibitors on human dentine erosion and abrasion in vitro |
author |
Hannas,Angelica Reis |
author_facet |
Hannas,Angelica Reis Kato,Melissa Thiemi Cardoso,Cristiane de Almeida Baldini Magalhães,Ana Carolina Pereira,José Carlos Tjäderhane,Leo Buzalaf,Marília Afonso Rabelo |
author_role |
author |
author2 |
Kato,Melissa Thiemi Cardoso,Cristiane de Almeida Baldini Magalhães,Ana Carolina Pereira,José Carlos Tjäderhane,Leo Buzalaf,Marília Afonso Rabelo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Hannas,Angelica Reis Kato,Melissa Thiemi Cardoso,Cristiane de Almeida Baldini Magalhães,Ana Carolina Pereira,José Carlos Tjäderhane,Leo Buzalaf,Marília Afonso Rabelo |
dc.subject.por.fl_str_mv |
Erosion Dentin Matrix metalloproteinases Inhibitors Toothpastes |
topic |
Erosion Dentin Matrix metalloproteinases Inhibitors Toothpastes |
description |
ABSTRACT The use of gels and mouthrinses with MMP inhibitors (chlorhexidine, and green tea extract) was shown to prevent erosive wear. The aim of this study was to analyze the protective effect of toothpastes containing MMP inhibitors on dentine loss induced by erosion in vitro. Material and Methods Five groups each containing 12 specimens of human root dentine were prepared. The specimens were subjected to 1 min erosion by immersion in a cola drink, 4 times a day, for 5 d. Each day, after the first and last erosive challenges, the specimens were brushed for 15 s with a slurry of dentifrice and water (1:3) containing placebo, 1,100 ppm fluoride, 0.61% green tea extract, 0.12% chlorhexidine or 0.004% chlorhexidine (commercial toothpaste). Between the acid challenges, the specimens were stored in artificial saliva with remineralizing potential until the next treatment. Dentine loss was determined using profilometry. Data were analyzed using one-way ANOVA after log transform (p<0.05). Results The mean wear values (μm) were as follows: placebo 1.83±0.53; 0.61% green tea extract 1.00±0.21; fluoride 1.27±0.43; 0.12% chlorhexidine 1.19±0.30; and 0.004% chlorhexidine 1.22±0.46. There was a significant difference in wear between placebo and all the treatment toothpastes, which did not differ from each other. Conclusion The results suggest that toothpastes containing MMP inhibitors are as effective as those based on NaF in preventing dentine erosion and abrasion. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572016000100061 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572016000100061 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-775720150289 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science v.24 n.1 2016 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1748936438658891776 |