Development of periradicular lesions in normal and diabetic rats
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572006000500013 |
Resumo: | Evidence suggests that diabetic patients are more significantly affected by problems of endodontic origin. This study sought to radiographically and histologically examine the development of periradicular inflammation in control and in diabetic rats after induction of pulpal infection. The pulps of the mandibular first molars of normal and streptozotocin-induced diabetic rats were exposed and left in contact with their oral cavities for 21 and 40 days. Afterwards, the animals were sacrificed, the mandibles were surgically removed, fixed in formalin and then radiographed in a standardized position. The radiographic images of the periradicular lesions were scanned and computerized images were evaluated for the total area of the lesions using a specific software. Representative specimens were also prepared for histopathological analysis. Radiographic analysis revealed that diabetic rats presented significantly larger periradicular lesions when compared with control rats, regardless of the experimental period (p<0.05). Histopathological examination of representative specimens revealed larger periradicular lesions and more severe inflammatory exudate in the group of diabetic rats when compared with the control group. Data from the present study indicated that diabetic rats can be more prone to develop large periradicular lesions, possibly due to reduction in the defense ability against microbial pathogens. |
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Journal of applied oral science (Online) |
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spelling |
Development of periradicular lesions in normal and diabetic ratsEndodontic infectionApical periodontitisDiabetesEvidence suggests that diabetic patients are more significantly affected by problems of endodontic origin. This study sought to radiographically and histologically examine the development of periradicular inflammation in control and in diabetic rats after induction of pulpal infection. The pulps of the mandibular first molars of normal and streptozotocin-induced diabetic rats were exposed and left in contact with their oral cavities for 21 and 40 days. Afterwards, the animals were sacrificed, the mandibles were surgically removed, fixed in formalin and then radiographed in a standardized position. The radiographic images of the periradicular lesions were scanned and computerized images were evaluated for the total area of the lesions using a specific software. Representative specimens were also prepared for histopathological analysis. Radiographic analysis revealed that diabetic rats presented significantly larger periradicular lesions when compared with control rats, regardless of the experimental period (p<0.05). Histopathological examination of representative specimens revealed larger periradicular lesions and more severe inflammatory exudate in the group of diabetic rats when compared with the control group. Data from the present study indicated that diabetic rats can be more prone to develop large periradicular lesions, possibly due to reduction in the defense ability against microbial pathogens.Faculdade De Odontologia De Bauru - USP2006-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572006000500013Journal of Applied Oral Science v.14 n.5 2006reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/S1678-77572006000500013info:eu-repo/semantics/openAccessArmada-Dias,LuciBreda,JorgeProvenzano,José ClaudioBreitenbach,MarisaRôças,Isabela das NevesGahyva,Sérgio Márcio MottaSiqueira Junior,José Freitaseng2007-01-09T00:00:00Zoai:scielo:S1678-77572006000500013Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2007-01-09T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Development of periradicular lesions in normal and diabetic rats |
title |
Development of periradicular lesions in normal and diabetic rats |
spellingShingle |
Development of periradicular lesions in normal and diabetic rats Armada-Dias,Luci Endodontic infection Apical periodontitis Diabetes |
title_short |
Development of periradicular lesions in normal and diabetic rats |
title_full |
Development of periradicular lesions in normal and diabetic rats |
title_fullStr |
Development of periradicular lesions in normal and diabetic rats |
title_full_unstemmed |
Development of periradicular lesions in normal and diabetic rats |
title_sort |
Development of periradicular lesions in normal and diabetic rats |
author |
Armada-Dias,Luci |
author_facet |
Armada-Dias,Luci Breda,Jorge Provenzano,José Claudio Breitenbach,Marisa Rôças,Isabela das Neves Gahyva,Sérgio Márcio Motta Siqueira Junior,José Freitas |
author_role |
author |
author2 |
Breda,Jorge Provenzano,José Claudio Breitenbach,Marisa Rôças,Isabela das Neves Gahyva,Sérgio Márcio Motta Siqueira Junior,José Freitas |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Armada-Dias,Luci Breda,Jorge Provenzano,José Claudio Breitenbach,Marisa Rôças,Isabela das Neves Gahyva,Sérgio Márcio Motta Siqueira Junior,José Freitas |
dc.subject.por.fl_str_mv |
Endodontic infection Apical periodontitis Diabetes |
topic |
Endodontic infection Apical periodontitis Diabetes |
description |
Evidence suggests that diabetic patients are more significantly affected by problems of endodontic origin. This study sought to radiographically and histologically examine the development of periradicular inflammation in control and in diabetic rats after induction of pulpal infection. The pulps of the mandibular first molars of normal and streptozotocin-induced diabetic rats were exposed and left in contact with their oral cavities for 21 and 40 days. Afterwards, the animals were sacrificed, the mandibles were surgically removed, fixed in formalin and then radiographed in a standardized position. The radiographic images of the periradicular lesions were scanned and computerized images were evaluated for the total area of the lesions using a specific software. Representative specimens were also prepared for histopathological analysis. Radiographic analysis revealed that diabetic rats presented significantly larger periradicular lesions when compared with control rats, regardless of the experimental period (p<0.05). Histopathological examination of representative specimens revealed larger periradicular lesions and more severe inflammatory exudate in the group of diabetic rats when compared with the control group. Data from the present study indicated that diabetic rats can be more prone to develop large periradicular lesions, possibly due to reduction in the defense ability against microbial pathogens. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572006000500013 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572006000500013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1678-77572006000500013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science v.14 n.5 2006 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1748936434341904384 |