Association of PIT1 genotypes with growth traits in Canchim cattle
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Scientia Agrícola (Online) |
Texto Completo: | https://www.revistas.usp.br/sa/article/view/22366 |
Resumo: | Use of genetic markers can aid on the identification of animals with highest breeding values in beef cattle. The PIT1 gene codes for the Pit-1 transcription factor is essential for the activation of prolactin, growth hormone and PIT1 genes. This research is an investigation of the effect of PIT1-HinfI polymorphism on growth traits of 509 Canchim animals, from two lineages, GG1 and GG2. PIT1 genotypes were identified through PCR-RFLP. Genotype effect on phenotypic values for birth weight (BW), standardized weaning weight (W240), weight at 12 months of age (W365), and the average daily weight gain from birth to weaning (AGBW), and from weaning to 12 months of age (AGW12) were analyzed by the least squares method. Effects of the interaction between the animal's genetic group and PIT1 genotype for W240, AGBW and AGW12 were observed (P < 0.05). Differences between means of HinfI (-/-), HinfI (+/+) and HinfI (+/-) genotypes for W240 and AGBW were observed in GG2 (P < 0.05), revealing superiority of (-/-) genotype for those traits. Means for genotypes (+/+) and (+/-) for W240 and AGBW, did not differ from one another, suggesting a dominance effect of the HinfI (+) allele. The HinfI (-) allele had a favorable effect on W240 and AGBW in GG2, when present in homozygosis. The difference between PIT1 behavior observed in the two genetic groups may suggest the action of a quantitative trait locus linked to PIT1, segregating only in GG2 population. |
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Association of PIT1 genotypes with growth traits in Canchim cattle Associação de genótipos PIT1 com características de crescimento em gado Canchim RFLPbovinosfator pituitário 1gene candidatoRFLPbovinepituitary factor 1candidate gene Use of genetic markers can aid on the identification of animals with highest breeding values in beef cattle. The PIT1 gene codes for the Pit-1 transcription factor is essential for the activation of prolactin, growth hormone and PIT1 genes. This research is an investigation of the effect of PIT1-HinfI polymorphism on growth traits of 509 Canchim animals, from two lineages, GG1 and GG2. PIT1 genotypes were identified through PCR-RFLP. Genotype effect on phenotypic values for birth weight (BW), standardized weaning weight (W240), weight at 12 months of age (W365), and the average daily weight gain from birth to weaning (AGBW), and from weaning to 12 months of age (AGW12) were analyzed by the least squares method. Effects of the interaction between the animal's genetic group and PIT1 genotype for W240, AGBW and AGW12 were observed (P < 0.05). Differences between means of HinfI (-/-), HinfI (+/+) and HinfI (+/-) genotypes for W240 and AGBW were observed in GG2 (P < 0.05), revealing superiority of (-/-) genotype for those traits. Means for genotypes (+/+) and (+/-) for W240 and AGBW, did not differ from one another, suggesting a dominance effect of the HinfI (+) allele. The HinfI (-) allele had a favorable effect on W240 and AGBW in GG2, when present in homozygosis. The difference between PIT1 behavior observed in the two genetic groups may suggest the action of a quantitative trait locus linked to PIT1, segregating only in GG2 population. O uso de marcadores genéticos pode favorecer a identificação de animais geneticamente superiores em bovino de corte. O gene PIT1 codifica para o fator de transcrição Pit-1, crítico para ativar a expressão dos genes da prolactina, hormônio de crescimento e PIT1. Esta pesquisa investiga o efeito do polimorfismo HinfI-PIT1 sobre características de crescimento em 509 animais da raça Canchim, pertencentes à duas linhagens, GG1 e GG2. Os genótipos do gene PIT1 foram identificados pela técnica PCR-RFLP. Os efeitos dos genótipos sobre valores fenotípicos para pesos ao nascimento (PN), pesos padronizados à desmama (P240) e ao ano (P365), ganhos médios diários de peso do nascimento à desmama (GMND), e da desmama aos 12 meses de idade (GMD12) foram analisados pelo método dos quadrados mínimos. Foram observados efeitos de interação entre grupo genético do animal e genótipo de PIT1 sobre P240, GMND e GMD12 (P < 0.05). Diferenças entre médias dos genótipos HinfI (-/-), HinfI (+/+) e HinfI (+/-) para P240 e GMND foram observadas em GG2 (P < 0,05), revelando superioridade do genótipo HinfI (-/-). As médias dos genótipos (+/+) e (+/-) para P240 e GMND, não diferiram, sugerindo efeito de dominância do alelo HinfI (+). O alelo HinfI (-) mostrou-se favorável sobre P240 e GMND em GG2, quando em homozigose. A diferença de comportamento de PIT1 observada nos dois grupos genéticos pode sugerir a ação de loco de característica quantitativa ligado ao gene PIT1, segregando apenas em GG2. Universidade de São Paulo. Escola Superior de Agricultura Luiz de Queiroz2008-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/sa/article/view/2236610.1590/S0103-90162008000200002Scientia Agricola; v. 65 n. 2 (2008); 116-121Scientia Agricola; Vol. 65 No. 2 (2008); 116-121Scientia Agricola; Vol. 65 Núm. 2 (2008); 116-1211678-992X0103-9016reponame:Scientia Agrícola (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/sa/article/view/22366/24390Copyright (c) 2015 Scientia Agricolainfo:eu-repo/semantics/openAccessCarrijo, Sônia MaraAlencar, Maurício Mello deToral, Fábio Luiz BuraneloRegitano, Luciana Correia de Almeida2015-07-07T17:35:17Zoai:revistas.usp.br:article/22366Revistahttp://revistas.usp.br/sa/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpscientia@usp.br||alleoni@usp.br1678-992X0103-9016opendoar:2015-07-07T17:35:17Scientia Agrícola (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Association of PIT1 genotypes with growth traits in Canchim cattle Associação de genótipos PIT1 com características de crescimento em gado Canchim |
title |
Association of PIT1 genotypes with growth traits in Canchim cattle |
spellingShingle |
Association of PIT1 genotypes with growth traits in Canchim cattle Carrijo, Sônia Mara RFLP bovinos fator pituitário 1 gene candidato RFLP bovine pituitary factor 1 candidate gene |
title_short |
Association of PIT1 genotypes with growth traits in Canchim cattle |
title_full |
Association of PIT1 genotypes with growth traits in Canchim cattle |
title_fullStr |
Association of PIT1 genotypes with growth traits in Canchim cattle |
title_full_unstemmed |
Association of PIT1 genotypes with growth traits in Canchim cattle |
title_sort |
Association of PIT1 genotypes with growth traits in Canchim cattle |
author |
Carrijo, Sônia Mara |
author_facet |
Carrijo, Sônia Mara Alencar, Maurício Mello de Toral, Fábio Luiz Buranelo Regitano, Luciana Correia de Almeida |
author_role |
author |
author2 |
Alencar, Maurício Mello de Toral, Fábio Luiz Buranelo Regitano, Luciana Correia de Almeida |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Carrijo, Sônia Mara Alencar, Maurício Mello de Toral, Fábio Luiz Buranelo Regitano, Luciana Correia de Almeida |
dc.subject.por.fl_str_mv |
RFLP bovinos fator pituitário 1 gene candidato RFLP bovine pituitary factor 1 candidate gene |
topic |
RFLP bovinos fator pituitário 1 gene candidato RFLP bovine pituitary factor 1 candidate gene |
description |
Use of genetic markers can aid on the identification of animals with highest breeding values in beef cattle. The PIT1 gene codes for the Pit-1 transcription factor is essential for the activation of prolactin, growth hormone and PIT1 genes. This research is an investigation of the effect of PIT1-HinfI polymorphism on growth traits of 509 Canchim animals, from two lineages, GG1 and GG2. PIT1 genotypes were identified through PCR-RFLP. Genotype effect on phenotypic values for birth weight (BW), standardized weaning weight (W240), weight at 12 months of age (W365), and the average daily weight gain from birth to weaning (AGBW), and from weaning to 12 months of age (AGW12) were analyzed by the least squares method. Effects of the interaction between the animal's genetic group and PIT1 genotype for W240, AGBW and AGW12 were observed (P < 0.05). Differences between means of HinfI (-/-), HinfI (+/+) and HinfI (+/-) genotypes for W240 and AGBW were observed in GG2 (P < 0.05), revealing superiority of (-/-) genotype for those traits. Means for genotypes (+/+) and (+/-) for W240 and AGBW, did not differ from one another, suggesting a dominance effect of the HinfI (+) allele. The HinfI (-) allele had a favorable effect on W240 and AGBW in GG2, when present in homozygosis. The difference between PIT1 behavior observed in the two genetic groups may suggest the action of a quantitative trait locus linked to PIT1, segregating only in GG2 population. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/sa/article/view/22366 10.1590/S0103-90162008000200002 |
url |
https://www.revistas.usp.br/sa/article/view/22366 |
identifier_str_mv |
10.1590/S0103-90162008000200002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/sa/article/view/22366/24390 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2015 Scientia Agricola info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2015 Scientia Agricola |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Escola Superior de Agricultura Luiz de Queiroz |
publisher.none.fl_str_mv |
Universidade de São Paulo. Escola Superior de Agricultura Luiz de Queiroz |
dc.source.none.fl_str_mv |
Scientia Agricola; v. 65 n. 2 (2008); 116-121 Scientia Agricola; Vol. 65 No. 2 (2008); 116-121 Scientia Agricola; Vol. 65 Núm. 2 (2008); 116-121 1678-992X 0103-9016 reponame:Scientia Agrícola (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Scientia Agrícola (Online) |
collection |
Scientia Agrícola (Online) |
repository.name.fl_str_mv |
Scientia Agrícola (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
scientia@usp.br||alleoni@usp.br |
_version_ |
1787713256896331776 |