Arterial stiffness and atrial fibrillation: A review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/213597 |
Resumo: | Arterial stiffness has been investigated as part of the physiopathology of arterial hypertension since the 1970s. Its role in increasing the “pulsatile load” imposed over the Left Ventricle (LV) has been intensely studied recently and has helped in understanding the mechanisms of Atrial Fibrillation (AF) in hypertensive patients. This paper aims to review the main evidence on this issue and establish possible mechanisms involved in the development of AF in patients with arterial stiffness. A PubMed search was performed, and selected articles were searched for references focusing on this topic. In the long term, lower blood pressure levels allow for arterial wall remodeling, leading to a lower stiffness index. To this day, however, there are no available treatments that directly promote the lowering of arterial wall stiffness. Most classes of anti-hypertensive drugs ‒ with stronger evidence for beta-blockers and diuretics ‒ could be effective in reducing arterial stiffness. There is strong evidence demonstrating an association between arterial stiffness and AF. New studies focusing on arterial stiffness and pre-fibrillatory stages would strengthen this causality relation. |
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Clinics |
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Arterial stiffness and atrial fibrillation: A reviewAtrial fibrillationArterial stiffnessAtrial arrhythmiaArterial stiffness has been investigated as part of the physiopathology of arterial hypertension since the 1970s. Its role in increasing the “pulsatile load” imposed over the Left Ventricle (LV) has been intensely studied recently and has helped in understanding the mechanisms of Atrial Fibrillation (AF) in hypertensive patients. This paper aims to review the main evidence on this issue and establish possible mechanisms involved in the development of AF in patients with arterial stiffness. A PubMed search was performed, and selected articles were searched for references focusing on this topic. In the long term, lower blood pressure levels allow for arterial wall remodeling, leading to a lower stiffness index. To this day, however, there are no available treatments that directly promote the lowering of arterial wall stiffness. Most classes of anti-hypertensive drugs ‒ with stronger evidence for beta-blockers and diuretics ‒ could be effective in reducing arterial stiffness. There is strong evidence demonstrating an association between arterial stiffness and AF. New studies focusing on arterial stiffness and pre-fibrillatory stages would strengthen this causality relation.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2022-03-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21359710.1016/j.clinsp.2022.100014Clinics; v. 77 (2022); 100014Clinics; Vol. 77 (2022); 100014Clinics; Vol. 77 (2022); 1000141980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/213597/195685Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessLage, João Gabriel BatistaBortolotto, Alexandre LemosScanavacca, Mauricio IbrahimBortolotto, Luiz AparecidoDarrieux, Francisco Carlos da Costa2023-06-25T13:55:10Zoai:revistas.usp.br:article/213597Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-06-25T13:55:10Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Arterial stiffness and atrial fibrillation: A review |
title |
Arterial stiffness and atrial fibrillation: A review |
spellingShingle |
Arterial stiffness and atrial fibrillation: A review Lage, João Gabriel Batista Atrial fibrillation Arterial stiffness Atrial arrhythmia |
title_short |
Arterial stiffness and atrial fibrillation: A review |
title_full |
Arterial stiffness and atrial fibrillation: A review |
title_fullStr |
Arterial stiffness and atrial fibrillation: A review |
title_full_unstemmed |
Arterial stiffness and atrial fibrillation: A review |
title_sort |
Arterial stiffness and atrial fibrillation: A review |
author |
Lage, João Gabriel Batista |
author_facet |
Lage, João Gabriel Batista Bortolotto, Alexandre Lemos Scanavacca, Mauricio Ibrahim Bortolotto, Luiz Aparecido Darrieux, Francisco Carlos da Costa |
author_role |
author |
author2 |
Bortolotto, Alexandre Lemos Scanavacca, Mauricio Ibrahim Bortolotto, Luiz Aparecido Darrieux, Francisco Carlos da Costa |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Lage, João Gabriel Batista Bortolotto, Alexandre Lemos Scanavacca, Mauricio Ibrahim Bortolotto, Luiz Aparecido Darrieux, Francisco Carlos da Costa |
dc.subject.por.fl_str_mv |
Atrial fibrillation Arterial stiffness Atrial arrhythmia |
topic |
Atrial fibrillation Arterial stiffness Atrial arrhythmia |
description |
Arterial stiffness has been investigated as part of the physiopathology of arterial hypertension since the 1970s. Its role in increasing the “pulsatile load” imposed over the Left Ventricle (LV) has been intensely studied recently and has helped in understanding the mechanisms of Atrial Fibrillation (AF) in hypertensive patients. This paper aims to review the main evidence on this issue and establish possible mechanisms involved in the development of AF in patients with arterial stiffness. A PubMed search was performed, and selected articles were searched for references focusing on this topic. In the long term, lower blood pressure levels allow for arterial wall remodeling, leading to a lower stiffness index. To this day, however, there are no available treatments that directly promote the lowering of arterial wall stiffness. Most classes of anti-hypertensive drugs ‒ with stronger evidence for beta-blockers and diuretics ‒ could be effective in reducing arterial stiffness. There is strong evidence demonstrating an association between arterial stiffness and AF. New studies focusing on arterial stiffness and pre-fibrillatory stages would strengthen this causality relation. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-03 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/213597 10.1016/j.clinsp.2022.100014 |
url |
https://www.revistas.usp.br/clinics/article/view/213597 |
identifier_str_mv |
10.1016/j.clinsp.2022.100014 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/213597/195685 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; v. 77 (2022); 100014 Clinics; Vol. 77 (2022); 100014 Clinics; Vol. 77 (2022); 100014 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1787713183836798976 |