Effects of early changes in organ dysfunctions on the outcomes of critically ill patients in need of renal replacement therapy

• Autor(a) principal: Maccariello, Elizabeth
• Data de Publicação: 2008
• Outros Autores: Rocha, Eduardo, Valente, Carla, Nogueira, Lina, Rocha, Pedro T., Bonomo Jr, Hélio, Serpa, Luciana F., Ismael, Márcia, Valença, Ricardo V. R., Machado, José E. S., Soares, Márcio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Clinics
• Texto Completo: https://www.revistas.usp.br/clinics/article/view/17804
• topic: Sequential Organ Failure Score; Dialysis; Acute kidney injury; Mortality; Outcome

INTRODUCTION: Acute kidney injury usually develops in critically ill patients in the context of multiple organ dysfunctions. OBJECTIVE: To evaluate the effect of changes in associated organ dysfunctions over the first three days of renal replacement therapy on the outcomes of patients with acute kidney injury. METHODS: Over a 19-month period, we evaluated 260 patients admitted to the intensive care units of three tertiary-care hospitals who required renal replacement therapy for >; 48 h. Organ dysfunctions were evaluated by SOFA score (excluding renal points) on the first (D1) and third (D3) days of renal replacement therapy. Absolute (A-SOFA) and relative (D-SOFA) changes in SOFA scores were also calculated. RESULTS: Hospital mortality rate was 75%. Organ dysfunctions worsened (A-SOFA>;0) in 53%, remained unchanged (A-SOFA=0) in 17% and improved (A-SOFA