Experimental study of histological changes in vascular loops according to the duration of the postoperative period: Application in reconstructive microsurgery
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/140030 |
Resumo: | OBJECTIVES: To analyze the histological changes observed in venous grafts subjected to arterial blood flow as a function of the duration of the postoperative period to optimize their use in free flap reconstructions. METHOD: Twenty-five rats (7 females and 18 males) underwent surgery. Surgeries were performed on one animal per week. Five weeks after the first surgery, the same five animals were subjected to an additional surgery to assess the presence or absence of blood flow through the vascular loop, and samples were collected for histological analysis. This cycle was performed five times. RESULTS: Of the rats euthanized four to five weeks after the first surgery, no blood flow was observed through the graft in 80% of the cases. In the group euthanized three weeks after the first surgery, no blood flow was observed in 20% of the cases. In the groups euthanized one to two weeks after the first surgery, blood flow through the vascular loop was observed in all animals. Moreover, intimal proliferation tended to increase with the duration of the postoperative period. Two weeks after surgery, intimal proliferation increased slightly, whereas strong intimal proliferation was observed in all rats evaluated five weeks after surgery. CONCLUSION: Intimal proliferation was the most significant change noted in venous grafts as a function of the duration of the postoperative period and was directly correlated with graft occlusion. In cases in which vascular loops are required during free flap reconstruction, both procedures should preferably be performed during the same surgery. |
id |
USP-19_30976467a468a1678851ea1e5835fc81 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/140030 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
Experimental study of histological changes in vascular loops according to the duration of the postoperative period: Application in reconstructive microsurgeryVascular LoopIntimal HyperplasiaVascular RemodelingOBJECTIVES: To analyze the histological changes observed in venous grafts subjected to arterial blood flow as a function of the duration of the postoperative period to optimize their use in free flap reconstructions. METHOD: Twenty-five rats (7 females and 18 males) underwent surgery. Surgeries were performed on one animal per week. Five weeks after the first surgery, the same five animals were subjected to an additional surgery to assess the presence or absence of blood flow through the vascular loop, and samples were collected for histological analysis. This cycle was performed five times. RESULTS: Of the rats euthanized four to five weeks after the first surgery, no blood flow was observed through the graft in 80% of the cases. In the group euthanized three weeks after the first surgery, no blood flow was observed in 20% of the cases. In the groups euthanized one to two weeks after the first surgery, blood flow through the vascular loop was observed in all animals. Moreover, intimal proliferation tended to increase with the duration of the postoperative period. Two weeks after surgery, intimal proliferation increased slightly, whereas strong intimal proliferation was observed in all rats evaluated five weeks after surgery. CONCLUSION: Intimal proliferation was the most significant change noted in venous grafts as a function of the duration of the postoperative period and was directly correlated with graft occlusion. In cases in which vascular loops are required during free flap reconstruction, both procedures should preferably be performed during the same surgery.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2017-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/14003010.6061/clinics/2017(09)03Clinics; Vol. 72 No. 9 (2017); 538-542Clinics; v. 72 n. 9 (2017); 538-542Clinics; Vol. 72 Núm. 9 (2017); 538-5421980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/140030/135230Copyright (c) 2017 Clinicsinfo:eu-repo/semantics/openAccessPaulos, Renata GregorioRudelli, Bruno AlvesFilippe, Renee Zondos Santos, Gustavo BispoHerrera, Ana AbarcaRibeiro, Andre Araujode Rezende, Marcelo RosaHsiang-Wei, TengMattar-Jr, Rames2017-10-25T11:34:41Zoai:revistas.usp.br:article/140030Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2017-10-25T11:34:41Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Experimental study of histological changes in vascular loops according to the duration of the postoperative period: Application in reconstructive microsurgery |
title |
Experimental study of histological changes in vascular loops according to the duration of the postoperative period: Application in reconstructive microsurgery |
spellingShingle |
Experimental study of histological changes in vascular loops according to the duration of the postoperative period: Application in reconstructive microsurgery Paulos, Renata Gregorio Vascular Loop Intimal Hyperplasia Vascular Remodeling |
title_short |
Experimental study of histological changes in vascular loops according to the duration of the postoperative period: Application in reconstructive microsurgery |
title_full |
Experimental study of histological changes in vascular loops according to the duration of the postoperative period: Application in reconstructive microsurgery |
title_fullStr |
Experimental study of histological changes in vascular loops according to the duration of the postoperative period: Application in reconstructive microsurgery |
title_full_unstemmed |
Experimental study of histological changes in vascular loops according to the duration of the postoperative period: Application in reconstructive microsurgery |
title_sort |
Experimental study of histological changes in vascular loops according to the duration of the postoperative period: Application in reconstructive microsurgery |
author |
Paulos, Renata Gregorio |
author_facet |
Paulos, Renata Gregorio Rudelli, Bruno Alves Filippe, Renee Zon dos Santos, Gustavo Bispo Herrera, Ana Abarca Ribeiro, Andre Araujo de Rezende, Marcelo Rosa Hsiang-Wei, Teng Mattar-Jr, Rames |
author_role |
author |
author2 |
Rudelli, Bruno Alves Filippe, Renee Zon dos Santos, Gustavo Bispo Herrera, Ana Abarca Ribeiro, Andre Araujo de Rezende, Marcelo Rosa Hsiang-Wei, Teng Mattar-Jr, Rames |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Paulos, Renata Gregorio Rudelli, Bruno Alves Filippe, Renee Zon dos Santos, Gustavo Bispo Herrera, Ana Abarca Ribeiro, Andre Araujo de Rezende, Marcelo Rosa Hsiang-Wei, Teng Mattar-Jr, Rames |
dc.subject.por.fl_str_mv |
Vascular Loop Intimal Hyperplasia Vascular Remodeling |
topic |
Vascular Loop Intimal Hyperplasia Vascular Remodeling |
description |
OBJECTIVES: To analyze the histological changes observed in venous grafts subjected to arterial blood flow as a function of the duration of the postoperative period to optimize their use in free flap reconstructions. METHOD: Twenty-five rats (7 females and 18 males) underwent surgery. Surgeries were performed on one animal per week. Five weeks after the first surgery, the same five animals were subjected to an additional surgery to assess the presence or absence of blood flow through the vascular loop, and samples were collected for histological analysis. This cycle was performed five times. RESULTS: Of the rats euthanized four to five weeks after the first surgery, no blood flow was observed through the graft in 80% of the cases. In the group euthanized three weeks after the first surgery, no blood flow was observed in 20% of the cases. In the groups euthanized one to two weeks after the first surgery, blood flow through the vascular loop was observed in all animals. Moreover, intimal proliferation tended to increase with the duration of the postoperative period. Two weeks after surgery, intimal proliferation increased slightly, whereas strong intimal proliferation was observed in all rats evaluated five weeks after surgery. CONCLUSION: Intimal proliferation was the most significant change noted in venous grafts as a function of the duration of the postoperative period and was directly correlated with graft occlusion. In cases in which vascular loops are required during free flap reconstruction, both procedures should preferably be performed during the same surgery. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/140030 10.6061/clinics/2017(09)03 |
url |
https://www.revistas.usp.br/clinics/article/view/140030 |
identifier_str_mv |
10.6061/clinics/2017(09)03 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/140030/135230 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 72 No. 9 (2017); 538-542 Clinics; v. 72 n. 9 (2017); 538-542 Clinics; Vol. 72 Núm. 9 (2017); 538-542 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222763241177088 |