Tgf-β1 expression as a biomarker of poor prognosis in prostate cancer

• Autor(a) principal: Reis, Sabrina Thalita dos
• Data de Publicação: 2011
• Outros Autores: Pontes-Júnior, Jose, Antunes, Alberto Azoubel, Sousa-Canavez, Juliana Moreira de, Abe, Daniel Kanda, Cruz, José Arnaldo Shiomi da, Dall'Oglio, Marcos Francisco, Crippa, Alexandre, Passerotti, Carlo Camargo, Ribeiro-Filho, Leopoldo A, Viana, Nayara Izabel, Srougi, Miguel, Leite, Kátia Ramos Moreira
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Clinics
• Texto Completo: https://www.revistas.usp.br/clinics/article/view/19352
• topic: Prostate cancer; Prognosis; Molecular markers; TGF-&#946

OBJECTIVE: To evaluate the correlation between transforming growth factor beta (TGF-β1) expression and prognosis in prostate cancer. PATIENTS AND METHODS: TGF-β1 expression levels were analyzed using the quantitative real-time polymerase chain reaction to amplify RNA that had been isolated from fresh-frozen malignant and benign tissue specimens collected from 89 patients who had clinically localized prostate cancer and had been treated with radical prostatectomy. The control group consisted of li patients with benign prostate hyperplasia. The expression levels of TGF-β1 were compared between the groups in terms of Gleason scores, pathological staging, and prostate-specific antigen serum levels. RESULTS: In the majority of the tumor samples, TGF-β1 was underexpressed 67.0% of PCa patients. The same expression pattern was identified in benign tissues of patients with prostate cancer. Although most cases exhibited underexpression of TGF-β1, a higher expression level was found in patients with Gleason scores >7 when compared to patients with Gleason scores