Exercise training reduces sympathetic nerve activity and improves executive performance in individuals with obstructive sleep apnea

Detalhes bibliográficos
Autor(a) principal: Goya, Thiago Tanaka
Data de Publicação: 2021
Outros Autores: Ferreira-Silva, Rosyvaldo, Gara, Elisangela Macedo, Guerra, Renan Segalla, Barbosa, Eline Rozária Ferreira, Toschi-Dias, Edgar, Cunha, Paulo Jannuzzi, Negrão, Carlos Eduardo, Lorenzi-Filho, Geraldo, Ueno-Pardi, Linda Massako
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/212936
Resumo: OBJECTIVE: To investigate the effects of exercise training (ET) on muscle sympathetic nerve activity (MSNA) and executive performance during Stroop Color Word Test (SCWT) also referred to as mental stress test. METHODS: Forty-four individuals with obstructive sleep apnea (OSA) and no significant co-morbidities were randomized into 2 groups; 15 individuals completed the control period, and 18 individuals completed the ET. Mini-mental state of examination and intelligence quotient were also assessed. MSNA assessed by microneurography, heart rate by electrocardiography, blood pressure (automated oscillometric device) were measured at baseline and during 3 min of the SCWT. Peak oxygen uptake (VO2 peak) was evaluated using cardiopulmonary exercise testing. Executive performance was assessed by the total correct responses during 3 min of the SCWT. ET consisted of 3 weekly sessions of aerobic exercise, resistance exercises, and flexibility (72 sessions, achieved in 40±3.9 weeks). RESULTS: Baseline parameters were similar between groups. Heart rate, blood pressure, and MSNA responses during SCWT were similar between groups (p>0.05). The comparisons between groups showed that the changes in VO2 (4.7±0.8 vs -1.2±0.4) and apnea-hypopnea index (-7.4±3.1 vs 5.5±3.3) in the exercise-trained group were significantly greater than those observed in the control group respectively (p<0.05) after intervention. ET reduced MSNA responses (p<0.05) and significantly increased the number of correct answers (12.4%) during SCWT. The number of correct answers was unchanged in the control group (p>0.05). CONCLUSIONS: ET improves sympathetic response and executive performance during SCWT, suggesting a prominent positive impact of ET on prefrontal functioning in individuals with OSA. ClinicalTrials.gov: NCT002289625.
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spelling Exercise training reduces sympathetic nerve activity and improves executive performance in individuals with obstructive sleep apneaExercise TrainingSympathetic Nervous SystemExecutive FunctionObstructive Sleep ApneaOBJECTIVE: To investigate the effects of exercise training (ET) on muscle sympathetic nerve activity (MSNA) and executive performance during Stroop Color Word Test (SCWT) also referred to as mental stress test. METHODS: Forty-four individuals with obstructive sleep apnea (OSA) and no significant co-morbidities were randomized into 2 groups; 15 individuals completed the control period, and 18 individuals completed the ET. Mini-mental state of examination and intelligence quotient were also assessed. MSNA assessed by microneurography, heart rate by electrocardiography, blood pressure (automated oscillometric device) were measured at baseline and during 3 min of the SCWT. Peak oxygen uptake (VO2 peak) was evaluated using cardiopulmonary exercise testing. Executive performance was assessed by the total correct responses during 3 min of the SCWT. ET consisted of 3 weekly sessions of aerobic exercise, resistance exercises, and flexibility (72 sessions, achieved in 40±3.9 weeks). RESULTS: Baseline parameters were similar between groups. Heart rate, blood pressure, and MSNA responses during SCWT were similar between groups (p>0.05). The comparisons between groups showed that the changes in VO2 (4.7±0.8 vs -1.2±0.4) and apnea-hypopnea index (-7.4±3.1 vs 5.5±3.3) in the exercise-trained group were significantly greater than those observed in the control group respectively (p<0.05) after intervention. ET reduced MSNA responses (p<0.05) and significantly increased the number of correct answers (12.4%) during SCWT. The number of correct answers was unchanged in the control group (p>0.05). CONCLUSIONS: ET improves sympathetic response and executive performance during SCWT, suggesting a prominent positive impact of ET on prefrontal functioning in individuals with OSA. ClinicalTrials.gov: NCT002289625.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2021-09-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21293610.6061/clinics/2021/e2786Clinics; Vol. 76 (2021); e2786Clinics; v. 76 (2021); e2786Clinics; Vol. 76 (2021); e27861980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/212936/194983Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessGoya, Thiago TanakaFerreira-Silva, RosyvaldoGara, Elisangela MacedoGuerra, Renan SegallaBarbosa, Eline Rozária FerreiraToschi-Dias, EdgarCunha, Paulo JannuzziNegrão, Carlos EduardoLorenzi-Filho, GeraldoUeno-Pardi, Linda Massako2023-07-06T13:04:05Zoai:revistas.usp.br:article/212936Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-07-06T13:04:05Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Exercise training reduces sympathetic nerve activity and improves executive performance in individuals with obstructive sleep apnea
title Exercise training reduces sympathetic nerve activity and improves executive performance in individuals with obstructive sleep apnea
spellingShingle Exercise training reduces sympathetic nerve activity and improves executive performance in individuals with obstructive sleep apnea
Goya, Thiago Tanaka
Exercise Training
Sympathetic Nervous System
Executive Function
Obstructive Sleep Apnea
title_short Exercise training reduces sympathetic nerve activity and improves executive performance in individuals with obstructive sleep apnea
title_full Exercise training reduces sympathetic nerve activity and improves executive performance in individuals with obstructive sleep apnea
title_fullStr Exercise training reduces sympathetic nerve activity and improves executive performance in individuals with obstructive sleep apnea
title_full_unstemmed Exercise training reduces sympathetic nerve activity and improves executive performance in individuals with obstructive sleep apnea
title_sort Exercise training reduces sympathetic nerve activity and improves executive performance in individuals with obstructive sleep apnea
author Goya, Thiago Tanaka
author_facet Goya, Thiago Tanaka
Ferreira-Silva, Rosyvaldo
Gara, Elisangela Macedo
Guerra, Renan Segalla
Barbosa, Eline Rozária Ferreira
Toschi-Dias, Edgar
Cunha, Paulo Jannuzzi
Negrão, Carlos Eduardo
Lorenzi-Filho, Geraldo
Ueno-Pardi, Linda Massako
author_role author
author2 Ferreira-Silva, Rosyvaldo
Gara, Elisangela Macedo
Guerra, Renan Segalla
Barbosa, Eline Rozária Ferreira
Toschi-Dias, Edgar
Cunha, Paulo Jannuzzi
Negrão, Carlos Eduardo
Lorenzi-Filho, Geraldo
Ueno-Pardi, Linda Massako
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Goya, Thiago Tanaka
Ferreira-Silva, Rosyvaldo
Gara, Elisangela Macedo
Guerra, Renan Segalla
Barbosa, Eline Rozária Ferreira
Toschi-Dias, Edgar
Cunha, Paulo Jannuzzi
Negrão, Carlos Eduardo
Lorenzi-Filho, Geraldo
Ueno-Pardi, Linda Massako
dc.subject.por.fl_str_mv Exercise Training
Sympathetic Nervous System
Executive Function
Obstructive Sleep Apnea
topic Exercise Training
Sympathetic Nervous System
Executive Function
Obstructive Sleep Apnea
description OBJECTIVE: To investigate the effects of exercise training (ET) on muscle sympathetic nerve activity (MSNA) and executive performance during Stroop Color Word Test (SCWT) also referred to as mental stress test. METHODS: Forty-four individuals with obstructive sleep apnea (OSA) and no significant co-morbidities were randomized into 2 groups; 15 individuals completed the control period, and 18 individuals completed the ET. Mini-mental state of examination and intelligence quotient were also assessed. MSNA assessed by microneurography, heart rate by electrocardiography, blood pressure (automated oscillometric device) were measured at baseline and during 3 min of the SCWT. Peak oxygen uptake (VO2 peak) was evaluated using cardiopulmonary exercise testing. Executive performance was assessed by the total correct responses during 3 min of the SCWT. ET consisted of 3 weekly sessions of aerobic exercise, resistance exercises, and flexibility (72 sessions, achieved in 40±3.9 weeks). RESULTS: Baseline parameters were similar between groups. Heart rate, blood pressure, and MSNA responses during SCWT were similar between groups (p>0.05). The comparisons between groups showed that the changes in VO2 (4.7±0.8 vs -1.2±0.4) and apnea-hypopnea index (-7.4±3.1 vs 5.5±3.3) in the exercise-trained group were significantly greater than those observed in the control group respectively (p<0.05) after intervention. ET reduced MSNA responses (p<0.05) and significantly increased the number of correct answers (12.4%) during SCWT. The number of correct answers was unchanged in the control group (p>0.05). CONCLUSIONS: ET improves sympathetic response and executive performance during SCWT, suggesting a prominent positive impact of ET on prefrontal functioning in individuals with OSA. ClinicalTrials.gov: NCT002289625.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/212936
10.6061/clinics/2021/e2786
url https://www.revistas.usp.br/clinics/article/view/212936
identifier_str_mv 10.6061/clinics/2021/e2786
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/212936/194983
dc.rights.driver.fl_str_mv Copyright (c) 2023 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 76 (2021); e2786
Clinics; v. 76 (2021); e2786
Clinics; Vol. 76 (2021); e2786
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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