Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/213307 |
Resumo: | Objectives: This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones. Methods: A high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS): a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox. Results: The high-risk group (n = 2,949; aged 53.6 ± 9.2; 65.5% women) and the ACS (n=1543; 52.2±8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS. Conclusions: The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID. |
id |
USP-19_782d1a8c785196af78d7005a78fbd46f |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/213307 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-BrasilChronic Inflammatory diseaseCardiovascular diseaseCoronary artery calcium (CAC)arotid intima-media thickness (CIMT)Fatal and non-fatal cardiovascular eventsObjectives: This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones. Methods: A high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS): a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox. Results: The high-risk group (n = 2,949; aged 53.6 ± 9.2; 65.5% women) and the ACS (n=1543; 52.2±8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS. Conclusions: The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2022-04-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21330710.1016/j.clinsp.2022.100013Clinics; v. 77 (2022); 100013Clinics; Vol. 77 (2022); 100013Clinics; Vol. 77 (2022); 1000131980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/213307/195255Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessBensenor, Isabela M.Goulart, Alessandra C.Pereira, Alexandre C.Brunoni, André R.Alencar, AirlaneSantos, Raul D.Bittencourt, Márcio S.Telles, Rosa W.Machado, Luciana Andrade CarneiroBarreto, Sandhi MariaAlmeida-Pititto, Bianca deJanovsky, Carolina Porto SilvaSgarbi, José AugustoTebar, William R.Meneghini, VandrizeBarbosa Junior, FernandoRibeiro, Ana Cristina de MedeirosPasoto, Sandra GofinetPereira, Rosa Maria R.Bonfá, EloísaSipahi, Aytan M.Santos, Itamar de S.Lotufo, Paulo A.2023-06-18T13:18:36Zoai:revistas.usp.br:article/213307Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-06-18T13:18:36Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil |
title |
Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil |
spellingShingle |
Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil Bensenor, Isabela M. Chronic Inflammatory disease Cardiovascular disease Coronary artery calcium (CAC) arotid intima-media thickness (CIMT) Fatal and non-fatal cardiovascular events |
title_short |
Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil |
title_full |
Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil |
title_fullStr |
Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil |
title_full_unstemmed |
Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil |
title_sort |
Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil |
author |
Bensenor, Isabela M. |
author_facet |
Bensenor, Isabela M. Goulart, Alessandra C. Pereira, Alexandre C. Brunoni, André R. Alencar, Airlane Santos, Raul D. Bittencourt, Márcio S. Telles, Rosa W. Machado, Luciana Andrade Carneiro Barreto, Sandhi Maria Almeida-Pititto, Bianca de Janovsky, Carolina Porto Silva Sgarbi, José Augusto Tebar, William R. Meneghini, Vandrize Barbosa Junior, Fernando Ribeiro, Ana Cristina de Medeiros Pasoto, Sandra Gofinet Pereira, Rosa Maria R. Bonfá, Eloísa Sipahi, Aytan M. Santos, Itamar de S. Lotufo, Paulo A. |
author_role |
author |
author2 |
Goulart, Alessandra C. Pereira, Alexandre C. Brunoni, André R. Alencar, Airlane Santos, Raul D. Bittencourt, Márcio S. Telles, Rosa W. Machado, Luciana Andrade Carneiro Barreto, Sandhi Maria Almeida-Pititto, Bianca de Janovsky, Carolina Porto Silva Sgarbi, José Augusto Tebar, William R. Meneghini, Vandrize Barbosa Junior, Fernando Ribeiro, Ana Cristina de Medeiros Pasoto, Sandra Gofinet Pereira, Rosa Maria R. Bonfá, Eloísa Sipahi, Aytan M. Santos, Itamar de S. Lotufo, Paulo A. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bensenor, Isabela M. Goulart, Alessandra C. Pereira, Alexandre C. Brunoni, André R. Alencar, Airlane Santos, Raul D. Bittencourt, Márcio S. Telles, Rosa W. Machado, Luciana Andrade Carneiro Barreto, Sandhi Maria Almeida-Pititto, Bianca de Janovsky, Carolina Porto Silva Sgarbi, José Augusto Tebar, William R. Meneghini, Vandrize Barbosa Junior, Fernando Ribeiro, Ana Cristina de Medeiros Pasoto, Sandra Gofinet Pereira, Rosa Maria R. Bonfá, Eloísa Sipahi, Aytan M. Santos, Itamar de S. Lotufo, Paulo A. |
dc.subject.por.fl_str_mv |
Chronic Inflammatory disease Cardiovascular disease Coronary artery calcium (CAC) arotid intima-media thickness (CIMT) Fatal and non-fatal cardiovascular events |
topic |
Chronic Inflammatory disease Cardiovascular disease Coronary artery calcium (CAC) arotid intima-media thickness (CIMT) Fatal and non-fatal cardiovascular events |
description |
Objectives: This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones. Methods: A high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS): a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox. Results: The high-risk group (n = 2,949; aged 53.6 ± 9.2; 65.5% women) and the ACS (n=1543; 52.2±8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS. Conclusions: The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-06 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/213307 10.1016/j.clinsp.2022.100013 |
url |
https://www.revistas.usp.br/clinics/article/view/213307 |
identifier_str_mv |
10.1016/j.clinsp.2022.100013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/213307/195255 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; v. 77 (2022); 100013 Clinics; Vol. 77 (2022); 100013 Clinics; Vol. 77 (2022); 100013 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1787713183407931392 |