pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/77290 |
Resumo: | OBJECTIVE: To utilize low-cost and simple methods to assess airway and lung inflammation biomarkers relatedto air pollution.METHODS: A total of 87 male, non-smorking, healthy subjects working as street traffic-controllers or office-workers were examined to determine carbon monoxide in ixhaled breath and to measure the pH in nasal lavage fluid and exhaled breath condensate. Air pollution exposure was measured by particulate matter concentration, and data were obtained from fixed monitoring stations (8-h work intervals per day, during the 5 consecutive days prior to the study).RESULTS: Exhaled carbon monoxide was two-fold greater in traffic-controllers than in office-workers. The mean pH values were 8.12 in exhaled breath condensate and 7.99 in nasal lavage fluid in office-workers; these values concentrations in both substrates, however, Il-aB and IL-8 were elevated in nasal lavage fluid compared with exhaled breath condensate. The particulate matter concentration weas greater at the workplace of traffic-controllers compared with that of office-workers.CONCLUSION: The pH values of nasal lavage fluid and exhaled breath condensate are important, robust, easy to measure and reproducible biomarkers that can be used to monitor occupational exposure to air pollution. Additionally, traffic-controllers are at an increased risk of airway and lung inflammation during their occupational activities compared with office-workers. |
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oai:revistas.usp.br:article/77290 |
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USP-19 |
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Clinics |
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pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workersExhaled Breath CondensateNasal Lavage FluidAir PollutionAirway Inflammation.OBJECTIVE: To utilize low-cost and simple methods to assess airway and lung inflammation biomarkers relatedto air pollution.METHODS: A total of 87 male, non-smorking, healthy subjects working as street traffic-controllers or office-workers were examined to determine carbon monoxide in ixhaled breath and to measure the pH in nasal lavage fluid and exhaled breath condensate. Air pollution exposure was measured by particulate matter concentration, and data were obtained from fixed monitoring stations (8-h work intervals per day, during the 5 consecutive days prior to the study).RESULTS: Exhaled carbon monoxide was two-fold greater in traffic-controllers than in office-workers. The mean pH values were 8.12 in exhaled breath condensate and 7.99 in nasal lavage fluid in office-workers; these values concentrations in both substrates, however, Il-aB and IL-8 were elevated in nasal lavage fluid compared with exhaled breath condensate. The particulate matter concentration weas greater at the workplace of traffic-controllers compared with that of office-workers.CONCLUSION: The pH values of nasal lavage fluid and exhaled breath condensate are important, robust, easy to measure and reproducible biomarkers that can be used to monitor occupational exposure to air pollution. Additionally, traffic-controllers are at an increased risk of airway and lung inflammation during their occupational activities compared with office-workers.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2013-12-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/7729010.1590/clin.v68i12.77290Clinics; Vol. 68 No. 12 (2013); 1488-1494Clinics; v. 68 n. 12 (2013); 1488-1494Clinics; Vol. 68 Núm. 12 (2013); 1488-14941980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/77290/81157Lima, Thamires Marques deKazama, Cristiane MayumiKoczulla, Andreas Rembert Koczulla RembertHiemstra, Pieter S.Macchione, MariangelaFernandes, Ana Luisa GodoySantos, Ubiratan de PaulaBueno-Garcia, Maria LuciaZanetta, Dirce MariaAndré, Carmen Diva Sadiva deSaldiva, Paulo Hilario NascimentoNakagawa, Naomi Kondoinfo:eu-repo/semantics/openAccess2015-06-16T11:28:21Zoai:revistas.usp.br:article/77290Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2015-06-16T11:28:21Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers |
title |
pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers |
spellingShingle |
pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers Lima, Thamires Marques de Exhaled Breath Condensate Nasal Lavage Fluid Air Pollution Airway Inflammation. |
title_short |
pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers |
title_full |
pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers |
title_fullStr |
pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers |
title_full_unstemmed |
pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers |
title_sort |
pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers |
author |
Lima, Thamires Marques de |
author_facet |
Lima, Thamires Marques de Kazama, Cristiane Mayumi Koczulla, Andreas Rembert Koczulla Rembert Hiemstra, Pieter S. Macchione, Mariangela Fernandes, Ana Luisa Godoy Santos, Ubiratan de Paula Bueno-Garcia, Maria Lucia Zanetta, Dirce Maria André, Carmen Diva Sadiva de Saldiva, Paulo Hilario Nascimento Nakagawa, Naomi Kondo |
author_role |
author |
author2 |
Kazama, Cristiane Mayumi Koczulla, Andreas Rembert Koczulla Rembert Hiemstra, Pieter S. Macchione, Mariangela Fernandes, Ana Luisa Godoy Santos, Ubiratan de Paula Bueno-Garcia, Maria Lucia Zanetta, Dirce Maria André, Carmen Diva Sadiva de Saldiva, Paulo Hilario Nascimento Nakagawa, Naomi Kondo |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lima, Thamires Marques de Kazama, Cristiane Mayumi Koczulla, Andreas Rembert Koczulla Rembert Hiemstra, Pieter S. Macchione, Mariangela Fernandes, Ana Luisa Godoy Santos, Ubiratan de Paula Bueno-Garcia, Maria Lucia Zanetta, Dirce Maria André, Carmen Diva Sadiva de Saldiva, Paulo Hilario Nascimento Nakagawa, Naomi Kondo |
dc.subject.por.fl_str_mv |
Exhaled Breath Condensate Nasal Lavage Fluid Air Pollution Airway Inflammation. |
topic |
Exhaled Breath Condensate Nasal Lavage Fluid Air Pollution Airway Inflammation. |
description |
OBJECTIVE: To utilize low-cost and simple methods to assess airway and lung inflammation biomarkers relatedto air pollution.METHODS: A total of 87 male, non-smorking, healthy subjects working as street traffic-controllers or office-workers were examined to determine carbon monoxide in ixhaled breath and to measure the pH in nasal lavage fluid and exhaled breath condensate. Air pollution exposure was measured by particulate matter concentration, and data were obtained from fixed monitoring stations (8-h work intervals per day, during the 5 consecutive days prior to the study).RESULTS: Exhaled carbon monoxide was two-fold greater in traffic-controllers than in office-workers. The mean pH values were 8.12 in exhaled breath condensate and 7.99 in nasal lavage fluid in office-workers; these values concentrations in both substrates, however, Il-aB and IL-8 were elevated in nasal lavage fluid compared with exhaled breath condensate. The particulate matter concentration weas greater at the workplace of traffic-controllers compared with that of office-workers.CONCLUSION: The pH values of nasal lavage fluid and exhaled breath condensate are important, robust, easy to measure and reproducible biomarkers that can be used to monitor occupational exposure to air pollution. Additionally, traffic-controllers are at an increased risk of airway and lung inflammation during their occupational activities compared with office-workers. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-31 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/77290 10.1590/clin.v68i12.77290 |
url |
https://www.revistas.usp.br/clinics/article/view/77290 |
identifier_str_mv |
10.1590/clin.v68i12.77290 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/77290/81157 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 68 No. 12 (2013); 1488-1494 Clinics; v. 68 n. 12 (2013); 1488-1494 Clinics; Vol. 68 Núm. 12 (2013); 1488-1494 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222761151365120 |