Germ Cell Tumors in Dysgenetic Gonads
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/164105 |
Resumo: | This review describes the germ cell neoplasms that are malignant and most commonly associated with several types of gonadal dysgenesis. The most common neoplasm is gonadoblastoma, while others including dysgerminomas, yolk-sac tumors and teratomas are rare but can occur. The purpose of this review is to evaluate the incidences of these abnormalities and the circumstances surrounding these specific tumors. According to well-established methods, a PubMed systematic review was performed, to obtain relevant studies published in English and select those with the highest-quality data. Initially, the first search was performed using gonadal dysgenesis as the search term, resulting in 12,887 PubMed papers, published, from 1945 to 2017. A second search using ovarian germ cell tumors as the search term resulted in 10,473 papers, published from 1960 to 2017. Another search was performed in Medline, using germ cell neoplasia as the search term, and this search resulted in 7,560 papers that were published between 2003 to 2016, with 245 new papers assessing gonadoblastomas. The higher incidence of germ cell tumors in gonadal dysgenesis is associated with a chromosomal anomaly that leads to the absence of germ cells in these gonads and, consequently, a higher incidence of neoplasms when these tumors are located inside the abdomen. Several hypotheses suggest that increased incidence of germ cell tumors involves all or part of the Y chromosome or different genes. |
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Germ Cell Tumors in Dysgenetic GonadsOvarian NeoplasmsGonadal DysgenesisGonadal NeoplasmsGonadoblastomaGerm Cells TumorsDysgerminomaTeratomaYolk-sac TumorThis review describes the germ cell neoplasms that are malignant and most commonly associated with several types of gonadal dysgenesis. The most common neoplasm is gonadoblastoma, while others including dysgerminomas, yolk-sac tumors and teratomas are rare but can occur. The purpose of this review is to evaluate the incidences of these abnormalities and the circumstances surrounding these specific tumors. According to well-established methods, a PubMed systematic review was performed, to obtain relevant studies published in English and select those with the highest-quality data. Initially, the first search was performed using gonadal dysgenesis as the search term, resulting in 12,887 PubMed papers, published, from 1945 to 2017. A second search using ovarian germ cell tumors as the search term resulted in 10,473 papers, published from 1960 to 2017. Another search was performed in Medline, using germ cell neoplasia as the search term, and this search resulted in 7,560 papers that were published between 2003 to 2016, with 245 new papers assessing gonadoblastomas. The higher incidence of germ cell tumors in gonadal dysgenesis is associated with a chromosomal anomaly that leads to the absence of germ cells in these gonads and, consequently, a higher incidence of neoplasms when these tumors are located inside the abdomen. Several hypotheses suggest that increased incidence of germ cell tumors involves all or part of the Y chromosome or different genes.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-11-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/16410510.6061/clinics/2019/e408Clinics; v. 74 (2019); e408Clinics; Vol. 74 (2019); e408Clinics; Vol. 74 (2019); e4081980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/164105/157538https://www.revistas.usp.br/clinics/article/view/164105/157539Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessPiazza, Mauri JoséUrbanetz, Almir Antonio2019-11-14T12:36:05Zoai:revistas.usp.br:article/164105Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-11-14T12:36:05Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Germ Cell Tumors in Dysgenetic Gonads |
title |
Germ Cell Tumors in Dysgenetic Gonads |
spellingShingle |
Germ Cell Tumors in Dysgenetic Gonads Piazza, Mauri José Ovarian Neoplasms Gonadal Dysgenesis Gonadal Neoplasms Gonadoblastoma Germ Cells Tumors Dysgerminoma Teratoma Yolk-sac Tumor |
title_short |
Germ Cell Tumors in Dysgenetic Gonads |
title_full |
Germ Cell Tumors in Dysgenetic Gonads |
title_fullStr |
Germ Cell Tumors in Dysgenetic Gonads |
title_full_unstemmed |
Germ Cell Tumors in Dysgenetic Gonads |
title_sort |
Germ Cell Tumors in Dysgenetic Gonads |
author |
Piazza, Mauri José |
author_facet |
Piazza, Mauri José Urbanetz, Almir Antonio |
author_role |
author |
author2 |
Urbanetz, Almir Antonio |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Piazza, Mauri José Urbanetz, Almir Antonio |
dc.subject.por.fl_str_mv |
Ovarian Neoplasms Gonadal Dysgenesis Gonadal Neoplasms Gonadoblastoma Germ Cells Tumors Dysgerminoma Teratoma Yolk-sac Tumor |
topic |
Ovarian Neoplasms Gonadal Dysgenesis Gonadal Neoplasms Gonadoblastoma Germ Cells Tumors Dysgerminoma Teratoma Yolk-sac Tumor |
description |
This review describes the germ cell neoplasms that are malignant and most commonly associated with several types of gonadal dysgenesis. The most common neoplasm is gonadoblastoma, while others including dysgerminomas, yolk-sac tumors and teratomas are rare but can occur. The purpose of this review is to evaluate the incidences of these abnormalities and the circumstances surrounding these specific tumors. According to well-established methods, a PubMed systematic review was performed, to obtain relevant studies published in English and select those with the highest-quality data. Initially, the first search was performed using gonadal dysgenesis as the search term, resulting in 12,887 PubMed papers, published, from 1945 to 2017. A second search using ovarian germ cell tumors as the search term resulted in 10,473 papers, published from 1960 to 2017. Another search was performed in Medline, using germ cell neoplasia as the search term, and this search resulted in 7,560 papers that were published between 2003 to 2016, with 245 new papers assessing gonadoblastomas. The higher incidence of germ cell tumors in gonadal dysgenesis is associated with a chromosomal anomaly that leads to the absence of germ cells in these gonads and, consequently, a higher incidence of neoplasms when these tumors are located inside the abdomen. Several hypotheses suggest that increased incidence of germ cell tumors involves all or part of the Y chromosome or different genes. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/164105 10.6061/clinics/2019/e408 |
url |
https://www.revistas.usp.br/clinics/article/view/164105 |
identifier_str_mv |
10.6061/clinics/2019/e408 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/164105/157538 https://www.revistas.usp.br/clinics/article/view/164105/157539 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; v. 74 (2019); e408 Clinics; Vol. 74 (2019); e408 Clinics; Vol. 74 (2019); e408 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1787713181475405824 |