Time-related effects of general functional training in spinal cord-injured rats

Detalhes bibliográficos
Autor(a) principal: Miranda, Taisa Amoroso Bortolato
Data de Publicação: 2012
Outros Autores: Vicente, Juliana Mendes Yule, Marcon, Raphael Martus, Cristante, Alexandre Fogaça, Morya, Edgard, Valle, Angela Cristina do
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/40157
Resumo: OBJECTIVES: This prospective, randomized, experimental study with rats aimed to investigate the influence of general treatment strategies on the motor recovery of Wistar rats with moderate contusive spinal cord injury. METHODS: A total of 51 Wistar rats were randomized into five groups: control, maze, ramp, runway, and sham (laminectomy only). The rats underwent spinal cord injury at the T9-T10 levels using the NYU-Impactor. Each group was trained for 12 minutes twice a week for two weeks before and five weeks after the spinal cord injury, except for the control group. Functional motor recovery was assessed with the Basso, Beattie, and Bresnahan Scale on the first postoperative day and then once a week for five weeks. The animals were euthanized, and the spinal cords were collected for histological analysis. RESULTS: Ramp and maze groups showed an earlier and greater functional improvement effect than the control and runway groups. However, over time, unexpectedly, all of the groups showed similar effects as the control group, with spontaneous recovery. There were no histological differences in the injured area between the trained and control groups. CONCLUSION: Short-term benefits can be associated with a specific training regime; however, the same training was ineffective at maintaining superior long-term recovery. These results might support new considerations before hospital discharge of patients with spinal cord injuries.
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spelling Time-related effects of general functional training in spinal cord-injured ratsSpinal cord injuryRehabilitationExercise movement techniquesOBJECTIVES: This prospective, randomized, experimental study with rats aimed to investigate the influence of general treatment strategies on the motor recovery of Wistar rats with moderate contusive spinal cord injury. METHODS: A total of 51 Wistar rats were randomized into five groups: control, maze, ramp, runway, and sham (laminectomy only). The rats underwent spinal cord injury at the T9-T10 levels using the NYU-Impactor. Each group was trained for 12 minutes twice a week for two weeks before and five weeks after the spinal cord injury, except for the control group. Functional motor recovery was assessed with the Basso, Beattie, and Bresnahan Scale on the first postoperative day and then once a week for five weeks. The animals were euthanized, and the spinal cords were collected for histological analysis. RESULTS: Ramp and maze groups showed an earlier and greater functional improvement effect than the control and runway groups. However, over time, unexpectedly, all of the groups showed similar effects as the control group, with spontaneous recovery. There were no histological differences in the injured area between the trained and control groups. CONCLUSION: Short-term benefits can be associated with a specific training regime; however, the same training was ineffective at maintaining superior long-term recovery. These results might support new considerations before hospital discharge of patients with spinal cord injuries.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2012-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/4015710.6061/clinics/2012(07)16Clinics; Vol. 67 No. 7 (2012); 799-804Clinics; v. 67 n. 7 (2012); 799-804Clinics; Vol. 67 Núm. 7 (2012); 799-8041980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/40157/43023Miranda, Taisa Amoroso BortolatoVicente, Juliana Mendes YuleMarcon, Raphael MartusCristante, Alexandre FogaçaMorya, EdgardValle, Angela Cristina doinfo:eu-repo/semantics/openAccess2012-08-23T18:32:14Zoai:revistas.usp.br:article/40157Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-08-23T18:32:14Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Time-related effects of general functional training in spinal cord-injured rats
title Time-related effects of general functional training in spinal cord-injured rats
spellingShingle Time-related effects of general functional training in spinal cord-injured rats
Miranda, Taisa Amoroso Bortolato
Spinal cord injury
Rehabilitation
Exercise movement techniques
title_short Time-related effects of general functional training in spinal cord-injured rats
title_full Time-related effects of general functional training in spinal cord-injured rats
title_fullStr Time-related effects of general functional training in spinal cord-injured rats
title_full_unstemmed Time-related effects of general functional training in spinal cord-injured rats
title_sort Time-related effects of general functional training in spinal cord-injured rats
author Miranda, Taisa Amoroso Bortolato
author_facet Miranda, Taisa Amoroso Bortolato
Vicente, Juliana Mendes Yule
Marcon, Raphael Martus
Cristante, Alexandre Fogaça
Morya, Edgard
Valle, Angela Cristina do
author_role author
author2 Vicente, Juliana Mendes Yule
Marcon, Raphael Martus
Cristante, Alexandre Fogaça
Morya, Edgard
Valle, Angela Cristina do
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Miranda, Taisa Amoroso Bortolato
Vicente, Juliana Mendes Yule
Marcon, Raphael Martus
Cristante, Alexandre Fogaça
Morya, Edgard
Valle, Angela Cristina do
dc.subject.por.fl_str_mv Spinal cord injury
Rehabilitation
Exercise movement techniques
topic Spinal cord injury
Rehabilitation
Exercise movement techniques
description OBJECTIVES: This prospective, randomized, experimental study with rats aimed to investigate the influence of general treatment strategies on the motor recovery of Wistar rats with moderate contusive spinal cord injury. METHODS: A total of 51 Wistar rats were randomized into five groups: control, maze, ramp, runway, and sham (laminectomy only). The rats underwent spinal cord injury at the T9-T10 levels using the NYU-Impactor. Each group was trained for 12 minutes twice a week for two weeks before and five weeks after the spinal cord injury, except for the control group. Functional motor recovery was assessed with the Basso, Beattie, and Bresnahan Scale on the first postoperative day and then once a week for five weeks. The animals were euthanized, and the spinal cords were collected for histological analysis. RESULTS: Ramp and maze groups showed an earlier and greater functional improvement effect than the control and runway groups. However, over time, unexpectedly, all of the groups showed similar effects as the control group, with spontaneous recovery. There were no histological differences in the injured area between the trained and control groups. CONCLUSION: Short-term benefits can be associated with a specific training regime; however, the same training was ineffective at maintaining superior long-term recovery. These results might support new considerations before hospital discharge of patients with spinal cord injuries.
publishDate 2012
dc.date.none.fl_str_mv 2012-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/40157
10.6061/clinics/2012(07)16
url https://www.revistas.usp.br/clinics/article/view/40157
identifier_str_mv 10.6061/clinics/2012(07)16
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/40157/43023
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 67 No. 7 (2012); 799-804
Clinics; v. 67 n. 7 (2012); 799-804
Clinics; Vol. 67 Núm. 7 (2012); 799-804
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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