Impact of clinical characteristics on human chorionic gonadotropin regression after molar pregnancy
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/212961 |
Resumo: | OBJECTIVES: This study aimed to determine the effects of age, race/ethnicity, body mass index, and contraception on human chorionic gonadotropin (hCG) regression following the evacuation of a molar pregnancy. METHODS: This was a retrospective cohort study of 277 patients with molar pregnancies between January 1, 1994 and December 31, 2015. The rate of hCG regression was estimated using mixed-effects linear regression models on daily log-transformed serum hCG levels after evacuation. RESULTS: There were no differences in hCG half-lives among age (p=0.13) or race/ethnicity (p=0.16) groups. Women with obesity and hormonal contraceptive use demonstrated faster hCG regression than their counterparts (3.2 versus. 3.7 days, p=0.02 and 3.4 versus. 4.0 days, p=0.002, respectively). CONCLUSION: Age and race/ethnicity were not associated with hCG regression rates. Hormonal contraceptive use and obesity were associated with shorter hCG half-lives, but with unlikely clinical significance. It is important to understand whether the clinical characteristics of patients may influence the hCG regression curve, as it has been proposed as a way to predict the risk of gestational trophoblastic neoplasia. |
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Clinics |
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Impact of clinical characteristics on human chorionic gonadotropin regression after molar pregnancyGestational Trophoblastic DiseaseChorionic GonadotropinMolar PregnancyOBJECTIVES: This study aimed to determine the effects of age, race/ethnicity, body mass index, and contraception on human chorionic gonadotropin (hCG) regression following the evacuation of a molar pregnancy. METHODS: This was a retrospective cohort study of 277 patients with molar pregnancies between January 1, 1994 and December 31, 2015. The rate of hCG regression was estimated using mixed-effects linear regression models on daily log-transformed serum hCG levels after evacuation. RESULTS: There were no differences in hCG half-lives among age (p=0.13) or race/ethnicity (p=0.16) groups. Women with obesity and hormonal contraceptive use demonstrated faster hCG regression than their counterparts (3.2 versus. 3.7 days, p=0.02 and 3.4 versus. 4.0 days, p=0.002, respectively). CONCLUSION: Age and race/ethnicity were not associated with hCG regression rates. Hormonal contraceptive use and obesity were associated with shorter hCG half-lives, but with unlikely clinical significance. It is important to understand whether the clinical characteristics of patients may influence the hCG regression curve, as it has been proposed as a way to predict the risk of gestational trophoblastic neoplasia.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2021-08-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21296110.6061/clinics/2021/e2830Clinics; Vol. 76 (2021); e2830Clinics; v. 76 (2021); e2830Clinics; Vol. 76 (2021); e28301980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/212961/194991Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessGockley, Allison A.Lin, Lawrence H.Davis, MichelleMelamed, AlexanderRizzo, AnthonySun, Sue YazakiElias, KevinGoldstein, Donald P.Berkowitz, Ross StuartHorowitz, Neil S.2023-07-06T13:04:06Zoai:revistas.usp.br:article/212961Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-07-06T13:04:06Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Impact of clinical characteristics on human chorionic gonadotropin regression after molar pregnancy |
title |
Impact of clinical characteristics on human chorionic gonadotropin regression after molar pregnancy |
spellingShingle |
Impact of clinical characteristics on human chorionic gonadotropin regression after molar pregnancy Gockley, Allison A. Gestational Trophoblastic Disease Chorionic Gonadotropin Molar Pregnancy |
title_short |
Impact of clinical characteristics on human chorionic gonadotropin regression after molar pregnancy |
title_full |
Impact of clinical characteristics on human chorionic gonadotropin regression after molar pregnancy |
title_fullStr |
Impact of clinical characteristics on human chorionic gonadotropin regression after molar pregnancy |
title_full_unstemmed |
Impact of clinical characteristics on human chorionic gonadotropin regression after molar pregnancy |
title_sort |
Impact of clinical characteristics on human chorionic gonadotropin regression after molar pregnancy |
author |
Gockley, Allison A. |
author_facet |
Gockley, Allison A. Lin, Lawrence H. Davis, Michelle Melamed, Alexander Rizzo, Anthony Sun, Sue Yazaki Elias, Kevin Goldstein, Donald P. Berkowitz, Ross Stuart Horowitz, Neil S. |
author_role |
author |
author2 |
Lin, Lawrence H. Davis, Michelle Melamed, Alexander Rizzo, Anthony Sun, Sue Yazaki Elias, Kevin Goldstein, Donald P. Berkowitz, Ross Stuart Horowitz, Neil S. |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gockley, Allison A. Lin, Lawrence H. Davis, Michelle Melamed, Alexander Rizzo, Anthony Sun, Sue Yazaki Elias, Kevin Goldstein, Donald P. Berkowitz, Ross Stuart Horowitz, Neil S. |
dc.subject.por.fl_str_mv |
Gestational Trophoblastic Disease Chorionic Gonadotropin Molar Pregnancy |
topic |
Gestational Trophoblastic Disease Chorionic Gonadotropin Molar Pregnancy |
description |
OBJECTIVES: This study aimed to determine the effects of age, race/ethnicity, body mass index, and contraception on human chorionic gonadotropin (hCG) regression following the evacuation of a molar pregnancy. METHODS: This was a retrospective cohort study of 277 patients with molar pregnancies between January 1, 1994 and December 31, 2015. The rate of hCG regression was estimated using mixed-effects linear regression models on daily log-transformed serum hCG levels after evacuation. RESULTS: There were no differences in hCG half-lives among age (p=0.13) or race/ethnicity (p=0.16) groups. Women with obesity and hormonal contraceptive use demonstrated faster hCG regression than their counterparts (3.2 versus. 3.7 days, p=0.02 and 3.4 versus. 4.0 days, p=0.002, respectively). CONCLUSION: Age and race/ethnicity were not associated with hCG regression rates. Hormonal contraceptive use and obesity were associated with shorter hCG half-lives, but with unlikely clinical significance. It is important to understand whether the clinical characteristics of patients may influence the hCG regression curve, as it has been proposed as a way to predict the risk of gestational trophoblastic neoplasia. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/212961 10.6061/clinics/2021/e2830 |
url |
https://www.revistas.usp.br/clinics/article/view/212961 |
identifier_str_mv |
10.6061/clinics/2021/e2830 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/212961/194991 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 76 (2021); e2830 Clinics; v. 76 (2021); e2830 Clinics; Vol. 76 (2021); e2830 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222766146781184 |