Serum bilirubin is negatively associated with white blood cell count
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/161184 |
Resumo: | OBJECTIVE: Bilirubin is considered an important antioxidant, anti-inflammatory factor and immunomodulator. The current investigation aimed to explore the association between bilirubin and white blood cell (WBC) count in a large Chinese cohort. METHODS: A total of 61091 participants (29259 males, 31832 females) were recruited from a Chinese tertiary hospital. Data were sorted by sex, and the association between bilirubin and WBC count was analyzed after dividing bilirubin levels into quartiles. RESULTS: Most parameters (including age, body mass index, systolic blood pressure, diastolic blood pressure, alanine aminotransferase, total bilirubin, blood urea nitrogen, creatinine, uric acid, triglycerides and WBC count) were significantly higher in men than in women. Bilirubin displayed significant negative relationships with most other measured variables. Linear logistic regression analysis further indicated their negative relationships. Females showed a significantly higher frequency of leucopenia than males. Significant associations of leucopenia with high bilirubin quartiles were shown in binary logistic regression models for both sexes, with a much closer association in men than in women. For instance, for men with bilirubin levels in quartile 4, the adjusted likelihood of leucopenia was 1.600-times higher than that of men with values in quartile 1. For women with bilirubin levels in quartile 4, the adjusted likelihood of leucopenia was 1.135-times higher than that of women with values in quartile 1. CONCLUSION: Bilirubin is negatively related to WBC count. Significant associations exist between leucopenia and high bilirubin quartiles, and these associations are more obvious in men than in women. |
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Clinics |
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Serum bilirubin is negatively associated with white blood cell countBilirubinWhite Blood Cell (WBC)SexOBJECTIVE: Bilirubin is considered an important antioxidant, anti-inflammatory factor and immunomodulator. The current investigation aimed to explore the association between bilirubin and white blood cell (WBC) count in a large Chinese cohort. METHODS: A total of 61091 participants (29259 males, 31832 females) were recruited from a Chinese tertiary hospital. Data were sorted by sex, and the association between bilirubin and WBC count was analyzed after dividing bilirubin levels into quartiles. RESULTS: Most parameters (including age, body mass index, systolic blood pressure, diastolic blood pressure, alanine aminotransferase, total bilirubin, blood urea nitrogen, creatinine, uric acid, triglycerides and WBC count) were significantly higher in men than in women. Bilirubin displayed significant negative relationships with most other measured variables. Linear logistic regression analysis further indicated their negative relationships. Females showed a significantly higher frequency of leucopenia than males. Significant associations of leucopenia with high bilirubin quartiles were shown in binary logistic regression models for both sexes, with a much closer association in men than in women. For instance, for men with bilirubin levels in quartile 4, the adjusted likelihood of leucopenia was 1.600-times higher than that of men with values in quartile 1. For women with bilirubin levels in quartile 4, the adjusted likelihood of leucopenia was 1.135-times higher than that of women with values in quartile 1. CONCLUSION: Bilirubin is negatively related to WBC count. Significant associations exist between leucopenia and high bilirubin quartiles, and these associations are more obvious in men than in women.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-08-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/16118410.6061/clinics/2019/e775Clinics; Vol. 74 (2019); e775Clinics; v. 74 (2019); e775Clinics; Vol. 74 (2019); e7751980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/161184/155169https://www.revistas.usp.br/clinics/article/view/161184/155170Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessZhang, LiZhang, ChunmeiMeng, ZhaoweiGong, LuPang, ChongjieLiu, Xiangxiang LiuZhang, QingJia, QiyuSong, Kun2019-08-19T12:52:43Zoai:revistas.usp.br:article/161184Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-08-19T12:52:43Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Serum bilirubin is negatively associated with white blood cell count |
title |
Serum bilirubin is negatively associated with white blood cell count |
spellingShingle |
Serum bilirubin is negatively associated with white blood cell count Zhang, Li Bilirubin White Blood Cell (WBC) Sex |
title_short |
Serum bilirubin is negatively associated with white blood cell count |
title_full |
Serum bilirubin is negatively associated with white blood cell count |
title_fullStr |
Serum bilirubin is negatively associated with white blood cell count |
title_full_unstemmed |
Serum bilirubin is negatively associated with white blood cell count |
title_sort |
Serum bilirubin is negatively associated with white blood cell count |
author |
Zhang, Li |
author_facet |
Zhang, Li Zhang, Chunmei Meng, Zhaowei Gong, Lu Pang, Chongjie Liu, Xiangxiang Liu Zhang, Qing Jia, Qiyu Song, Kun |
author_role |
author |
author2 |
Zhang, Chunmei Meng, Zhaowei Gong, Lu Pang, Chongjie Liu, Xiangxiang Liu Zhang, Qing Jia, Qiyu Song, Kun |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Zhang, Li Zhang, Chunmei Meng, Zhaowei Gong, Lu Pang, Chongjie Liu, Xiangxiang Liu Zhang, Qing Jia, Qiyu Song, Kun |
dc.subject.por.fl_str_mv |
Bilirubin White Blood Cell (WBC) Sex |
topic |
Bilirubin White Blood Cell (WBC) Sex |
description |
OBJECTIVE: Bilirubin is considered an important antioxidant, anti-inflammatory factor and immunomodulator. The current investigation aimed to explore the association between bilirubin and white blood cell (WBC) count in a large Chinese cohort. METHODS: A total of 61091 participants (29259 males, 31832 females) were recruited from a Chinese tertiary hospital. Data were sorted by sex, and the association between bilirubin and WBC count was analyzed after dividing bilirubin levels into quartiles. RESULTS: Most parameters (including age, body mass index, systolic blood pressure, diastolic blood pressure, alanine aminotransferase, total bilirubin, blood urea nitrogen, creatinine, uric acid, triglycerides and WBC count) were significantly higher in men than in women. Bilirubin displayed significant negative relationships with most other measured variables. Linear logistic regression analysis further indicated their negative relationships. Females showed a significantly higher frequency of leucopenia than males. Significant associations of leucopenia with high bilirubin quartiles were shown in binary logistic regression models for both sexes, with a much closer association in men than in women. For instance, for men with bilirubin levels in quartile 4, the adjusted likelihood of leucopenia was 1.600-times higher than that of men with values in quartile 1. For women with bilirubin levels in quartile 4, the adjusted likelihood of leucopenia was 1.135-times higher than that of women with values in quartile 1. CONCLUSION: Bilirubin is negatively related to WBC count. Significant associations exist between leucopenia and high bilirubin quartiles, and these associations are more obvious in men than in women. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08-19 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/161184 10.6061/clinics/2019/e775 |
url |
https://www.revistas.usp.br/clinics/article/view/161184 |
identifier_str_mv |
10.6061/clinics/2019/e775 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/161184/155169 https://www.revistas.usp.br/clinics/article/view/161184/155170 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 74 (2019); e775 Clinics; v. 74 (2019); e775 Clinics; Vol. 74 (2019); e775 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222764210061312 |