Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/174296 |
Resumo: | OBJECTIVES: We designed a cohort study to describe characteristics and outcomes of patients with coronavirus disease (COVID-19) admitted to the intensive care unit (ICU) in the largest public hospital in Sao Paulo, Brazil, as Latin America becomes the epicenter of the pandemic. METHODS: This is the protocol for a study being conducted at an academic hospital in Brazil with 300 adult ICU beds dedicated to COVID-19 patients. We will include adult patients admitted to the ICU with suspected or confirmed COVID-19 during the study period. The main outcome is ICU survival at 28 days. Data will be collected prospectively and retrospectively by trained investigators from the hospital’s electronic medical records, using an electronic data capture tool. We will collect data on demographics, comorbidities, severity of disease, and laboratorial test results at admission. Information on the need for advanced life support and ventilator parameters will be collected during ICU stay. Patients will be followed up for 28 days in the ICU and 60 days in the hospital. We will plot Kaplan-Meier curves to estimate ICU and hospital survival and perform survival analysis using the Cox proportional hazards model to identify the main risk factors for mortality. ClinicalTrials. gov: NCT04378582. RESULTS: We expect to include a large sample of patients with COVID-19 admitted to the ICU and to be able to provide data on admission characteristics, use of advanced life support, ICU survival at 28 days, and hospital survival at 60 days. CONCLUSIONS: This study will provide epidemiological data about critically ill patients with COVID-19 in Brazil, which could inform health policy and resource allocation in low- and middle-income countries. |
id |
USP-19_f95f27dcb95af1c17cc74d4f0bd15340 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/174296 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocolVentilationArtificialSevere Acute Respiratory SyndromeIntensive Care UnitsSARS VirusCOVID-19OBJECTIVES: We designed a cohort study to describe characteristics and outcomes of patients with coronavirus disease (COVID-19) admitted to the intensive care unit (ICU) in the largest public hospital in Sao Paulo, Brazil, as Latin America becomes the epicenter of the pandemic. METHODS: This is the protocol for a study being conducted at an academic hospital in Brazil with 300 adult ICU beds dedicated to COVID-19 patients. We will include adult patients admitted to the ICU with suspected or confirmed COVID-19 during the study period. The main outcome is ICU survival at 28 days. Data will be collected prospectively and retrospectively by trained investigators from the hospital’s electronic medical records, using an electronic data capture tool. We will collect data on demographics, comorbidities, severity of disease, and laboratorial test results at admission. Information on the need for advanced life support and ventilator parameters will be collected during ICU stay. Patients will be followed up for 28 days in the ICU and 60 days in the hospital. We will plot Kaplan-Meier curves to estimate ICU and hospital survival and perform survival analysis using the Cox proportional hazards model to identify the main risk factors for mortality. ClinicalTrials. gov: NCT04378582. RESULTS: We expect to include a large sample of patients with COVID-19 admitted to the ICU and to be able to provide data on admission characteristics, use of advanced life support, ICU survival at 28 days, and hospital survival at 60 days. CONCLUSIONS: This study will provide epidemiological data about critically ill patients with COVID-19 in Brazil, which could inform health policy and resource allocation in low- and middle-income countries.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2020-08-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/17429610.6061/clinics/2020/e2294Clinics; Vol. 75 (2020); e2294Clinics; v. 75 (2020); e2294Clinics; Vol. 75 (2020); e22941980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/174296/163147https://www.revistas.usp.br/clinics/article/view/174296/163148Copyright (c) 2020 Clinicsinfo:eu-repo/semantics/openAccessFerreira, Juliana C.Ho, Yeh-LiBesen, Bruno A. M. P.Malbuisson, Luiz M. S.Taniguchi, Leandro U.Mendes, Pedro V.Costa, Eduardo L. V.Park, MarceloDaltro-Oliveira, RenatoRoepke, Roberta M. L.Silva Júnior, João M.Carmona, Maria José C.Carvalho, Carlos Roberto RibeiroStudy Group, EPICCoV2020-08-30T21:23:06Zoai:revistas.usp.br:article/174296Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2020-08-30T21:23:06Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol |
title |
Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol |
spellingShingle |
Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol Ferreira, Juliana C. Ventilation Artificial Severe Acute Respiratory Syndrome Intensive Care Units SARS Virus COVID-19 |
title_short |
Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol |
title_full |
Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol |
title_fullStr |
Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol |
title_full_unstemmed |
Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol |
title_sort |
Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol |
author |
Ferreira, Juliana C. |
author_facet |
Ferreira, Juliana C. Ho, Yeh-Li Besen, Bruno A. M. P. Malbuisson, Luiz M. S. Taniguchi, Leandro U. Mendes, Pedro V. Costa, Eduardo L. V. Park, Marcelo Daltro-Oliveira, Renato Roepke, Roberta M. L. Silva Júnior, João M. Carmona, Maria José C. Carvalho, Carlos Roberto Ribeiro Study Group, EPICCoV |
author_role |
author |
author2 |
Ho, Yeh-Li Besen, Bruno A. M. P. Malbuisson, Luiz M. S. Taniguchi, Leandro U. Mendes, Pedro V. Costa, Eduardo L. V. Park, Marcelo Daltro-Oliveira, Renato Roepke, Roberta M. L. Silva Júnior, João M. Carmona, Maria José C. Carvalho, Carlos Roberto Ribeiro Study Group, EPICCoV |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, Juliana C. Ho, Yeh-Li Besen, Bruno A. M. P. Malbuisson, Luiz M. S. Taniguchi, Leandro U. Mendes, Pedro V. Costa, Eduardo L. V. Park, Marcelo Daltro-Oliveira, Renato Roepke, Roberta M. L. Silva Júnior, João M. Carmona, Maria José C. Carvalho, Carlos Roberto Ribeiro Study Group, EPICCoV |
dc.subject.por.fl_str_mv |
Ventilation Artificial Severe Acute Respiratory Syndrome Intensive Care Units SARS Virus COVID-19 |
topic |
Ventilation Artificial Severe Acute Respiratory Syndrome Intensive Care Units SARS Virus COVID-19 |
description |
OBJECTIVES: We designed a cohort study to describe characteristics and outcomes of patients with coronavirus disease (COVID-19) admitted to the intensive care unit (ICU) in the largest public hospital in Sao Paulo, Brazil, as Latin America becomes the epicenter of the pandemic. METHODS: This is the protocol for a study being conducted at an academic hospital in Brazil with 300 adult ICU beds dedicated to COVID-19 patients. We will include adult patients admitted to the ICU with suspected or confirmed COVID-19 during the study period. The main outcome is ICU survival at 28 days. Data will be collected prospectively and retrospectively by trained investigators from the hospital’s electronic medical records, using an electronic data capture tool. We will collect data on demographics, comorbidities, severity of disease, and laboratorial test results at admission. Information on the need for advanced life support and ventilator parameters will be collected during ICU stay. Patients will be followed up for 28 days in the ICU and 60 days in the hospital. We will plot Kaplan-Meier curves to estimate ICU and hospital survival and perform survival analysis using the Cox proportional hazards model to identify the main risk factors for mortality. ClinicalTrials. gov: NCT04378582. RESULTS: We expect to include a large sample of patients with COVID-19 admitted to the ICU and to be able to provide data on admission characteristics, use of advanced life support, ICU survival at 28 days, and hospital survival at 60 days. CONCLUSIONS: This study will provide epidemiological data about critically ill patients with COVID-19 in Brazil, which could inform health policy and resource allocation in low- and middle-income countries. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/174296 10.6061/clinics/2020/e2294 |
url |
https://www.revistas.usp.br/clinics/article/view/174296 |
identifier_str_mv |
10.6061/clinics/2020/e2294 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/174296/163147 https://www.revistas.usp.br/clinics/article/view/174296/163148 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 75 (2020); e2294 Clinics; v. 75 (2020); e2294 Clinics; Vol. 75 (2020); e2294 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222765229277184 |