Evaluation of conjunctival bacterial flora in patients with Stevens-Johnson Syndrome
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/77105 |
Resumo: | OBJECTIVE: To determine the conjunctival bacterial flora present in patients with Stevens-Johnson syndrome. METHODS: A prospective study of the conjunctival bacterial flora was performed in 41 eyes of 22 patients with Stevens-Johnson syndrome. The information gathered included the patient's sex and age, the duration of disease, the cause of Stevens-Johnson syndrome, and treatments. Scrapings of the inferior conjunctival fornix were performed in both eyes. Fourteen days before scraping, the patients were asked to interrupt all topical medication and start using 0.5% nonpreserved methylcellulose. The microbiological evaluation included microorganism identification and determination of antibiotic sensitivity. RESULTS: Of 22 patients (41 eyes), 14 (64%) were females, and eight (36%) were males. The mean age was 33.2 years, and the mean duration of disease was 15.6 years. Visual acuity ranged from light perception to 20/25 (1.57 logMar). The treatment received by most patients consisted of tear substitutes, topical antibiotics, and contact lenses. Bacterial identification was positive in 39 eyes (95%) and negative in two eyes (5%). Gram-positive cocci accounted for 55.5% of the microorganisms, whereas gram-positive bacilli and gram-negative bacilli accounted for 19% and 25.5%, respectively. Half of the patients (54%) had multiple bacterial species in their flora, and only one bacterial species was identified in the other half. Resistant bacteria were isolated from four eyes. The antibiotic sensitivity results for the Streptococcus group showed the lowest sensitivity and the highest microbial resistance identified. CONCLUSION: Patients with Stevens-Johnson syndrome have a diverse conjunctival flora that includes many pathogenic species. |
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Clinics |
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Evaluation of conjunctival bacterial flora in patients with Stevens-Johnson SyndromeOBJECTIVE: To determine the conjunctival bacterial flora present in patients with Stevens-Johnson syndrome. METHODS: A prospective study of the conjunctival bacterial flora was performed in 41 eyes of 22 patients with Stevens-Johnson syndrome. The information gathered included the patient's sex and age, the duration of disease, the cause of Stevens-Johnson syndrome, and treatments. Scrapings of the inferior conjunctival fornix were performed in both eyes. Fourteen days before scraping, the patients were asked to interrupt all topical medication and start using 0.5% nonpreserved methylcellulose. The microbiological evaluation included microorganism identification and determination of antibiotic sensitivity. RESULTS: Of 22 patients (41 eyes), 14 (64%) were females, and eight (36%) were males. The mean age was 33.2 years, and the mean duration of disease was 15.6 years. Visual acuity ranged from light perception to 20/25 (1.57 logMar). The treatment received by most patients consisted of tear substitutes, topical antibiotics, and contact lenses. Bacterial identification was positive in 39 eyes (95%) and negative in two eyes (5%). Gram-positive cocci accounted for 55.5% of the microorganisms, whereas gram-positive bacilli and gram-negative bacilli accounted for 19% and 25.5%, respectively. Half of the patients (54%) had multiple bacterial species in their flora, and only one bacterial species was identified in the other half. Resistant bacteria were isolated from four eyes. The antibiotic sensitivity results for the Streptococcus group showed the lowest sensitivity and the highest microbial resistance identified. CONCLUSION: Patients with Stevens-Johnson syndrome have a diverse conjunctival flora that includes many pathogenic species.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2014-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/7710510.1590/clin.v69i3.77105Clinics; Vol. 69 No. 3 (2014); 168-172Clinics; v. 69 n. 3 (2014); 168-172Clinics; Vol. 69 Núm. 3 (2014); 168-1721980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/77105/80973Frizon, LucianaAraujo, Marilia CavalcanteAndrade, LarissaYu, Maria Cecilia ZoratWakamatsu, Tais HitomiHofling-Lima, Ana LuisaGomes, Jose Alvaro Pereirainfo:eu-repo/semantics/openAccess2014-03-21T19:24:19Zoai:revistas.usp.br:article/77105Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2014-03-21T19:24:19Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Evaluation of conjunctival bacterial flora in patients with Stevens-Johnson Syndrome |
title |
Evaluation of conjunctival bacterial flora in patients with Stevens-Johnson Syndrome |
spellingShingle |
Evaluation of conjunctival bacterial flora in patients with Stevens-Johnson Syndrome Frizon, Luciana |
title_short |
Evaluation of conjunctival bacterial flora in patients with Stevens-Johnson Syndrome |
title_full |
Evaluation of conjunctival bacterial flora in patients with Stevens-Johnson Syndrome |
title_fullStr |
Evaluation of conjunctival bacterial flora in patients with Stevens-Johnson Syndrome |
title_full_unstemmed |
Evaluation of conjunctival bacterial flora in patients with Stevens-Johnson Syndrome |
title_sort |
Evaluation of conjunctival bacterial flora in patients with Stevens-Johnson Syndrome |
author |
Frizon, Luciana |
author_facet |
Frizon, Luciana Araujo, Marilia Cavalcante Andrade, Larissa Yu, Maria Cecilia Zorat Wakamatsu, Tais Hitomi Hofling-Lima, Ana Luisa Gomes, Jose Alvaro Pereira |
author_role |
author |
author2 |
Araujo, Marilia Cavalcante Andrade, Larissa Yu, Maria Cecilia Zorat Wakamatsu, Tais Hitomi Hofling-Lima, Ana Luisa Gomes, Jose Alvaro Pereira |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Frizon, Luciana Araujo, Marilia Cavalcante Andrade, Larissa Yu, Maria Cecilia Zorat Wakamatsu, Tais Hitomi Hofling-Lima, Ana Luisa Gomes, Jose Alvaro Pereira |
description |
OBJECTIVE: To determine the conjunctival bacterial flora present in patients with Stevens-Johnson syndrome. METHODS: A prospective study of the conjunctival bacterial flora was performed in 41 eyes of 22 patients with Stevens-Johnson syndrome. The information gathered included the patient's sex and age, the duration of disease, the cause of Stevens-Johnson syndrome, and treatments. Scrapings of the inferior conjunctival fornix were performed in both eyes. Fourteen days before scraping, the patients were asked to interrupt all topical medication and start using 0.5% nonpreserved methylcellulose. The microbiological evaluation included microorganism identification and determination of antibiotic sensitivity. RESULTS: Of 22 patients (41 eyes), 14 (64%) were females, and eight (36%) were males. The mean age was 33.2 years, and the mean duration of disease was 15.6 years. Visual acuity ranged from light perception to 20/25 (1.57 logMar). The treatment received by most patients consisted of tear substitutes, topical antibiotics, and contact lenses. Bacterial identification was positive in 39 eyes (95%) and negative in two eyes (5%). Gram-positive cocci accounted for 55.5% of the microorganisms, whereas gram-positive bacilli and gram-negative bacilli accounted for 19% and 25.5%, respectively. Half of the patients (54%) had multiple bacterial species in their flora, and only one bacterial species was identified in the other half. Resistant bacteria were isolated from four eyes. The antibiotic sensitivity results for the Streptococcus group showed the lowest sensitivity and the highest microbial resistance identified. CONCLUSION: Patients with Stevens-Johnson syndrome have a diverse conjunctival flora that includes many pathogenic species. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/77105 10.1590/clin.v69i3.77105 |
url |
https://www.revistas.usp.br/clinics/article/view/77105 |
identifier_str_mv |
10.1590/clin.v69i3.77105 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/77105/80973 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 69 No. 3 (2014); 168-172 Clinics; v. 69 n. 3 (2014); 168-172 Clinics; Vol. 69 Núm. 3 (2014); 168-172 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222761135636480 |