The association between vitamin D and BDNF on cognition in older adults in Southern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | https://www.revistas.usp.br/rsp/article/view/205761 |
Resumo: | OBJECTIVE: To estimate the association between vitamin D and the cognitive decline of older adults and evaluate whether this association is mediated by brain-derived neurotrophic factor (BDNF) serum concentration. METHODS: Cross-sectional study nested in a population-based cohort. Of the 604 participants in the complementary examination of the EpiFloripa Study, 576 older adults (60 years or older) were eligible for the study. The outcome is cognitive decline evaluated by the Mini-Mental State Examination, the exposure is vitamin D, and BDNF is the mediator. The control variables are age, sex, per capita family income, and educational level. The direct effect of vitamin D and BDNF on cognitive decline and the indirect effect mediated by BDNF was evaluated using path analysis, with the estimation of standardized coefficients. RESULTS: Among the participants, we observed a direct and positive effect of vitamin D on cognitive function (Coef: 0.06; 95%CI 0.02 to 0.11; p < 0.001) and serum BDNF concentration (Coef: 21.55; 95%CI 9.92 to 33.17; p = 0.002), i.e., the higher the vitamin D, the higher the cognitive function and serum level of BDNF. CONCLUSION: There was an association between vitamin D on serum BDNF and on cognitive decline in older adults. Moreover, BDNF did not have an effect on cognitive decline, so BDNF was not a mediator of the vitamin D effect on cognitive decline. |
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Revista de Saúde Pública |
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The association between vitamin D and BDNF on cognition in older adults in Southern BrazilAgedCognitionVitamin DBrain-Derived Neurotrophic FactorOBJECTIVE: To estimate the association between vitamin D and the cognitive decline of older adults and evaluate whether this association is mediated by brain-derived neurotrophic factor (BDNF) serum concentration. METHODS: Cross-sectional study nested in a population-based cohort. Of the 604 participants in the complementary examination of the EpiFloripa Study, 576 older adults (60 years or older) were eligible for the study. The outcome is cognitive decline evaluated by the Mini-Mental State Examination, the exposure is vitamin D, and BDNF is the mediator. The control variables are age, sex, per capita family income, and educational level. The direct effect of vitamin D and BDNF on cognitive decline and the indirect effect mediated by BDNF was evaluated using path analysis, with the estimation of standardized coefficients. RESULTS: Among the participants, we observed a direct and positive effect of vitamin D on cognitive function (Coef: 0.06; 95%CI 0.02 to 0.11; p < 0.001) and serum BDNF concentration (Coef: 21.55; 95%CI 9.92 to 33.17; p = 0.002), i.e., the higher the vitamin D, the higher the cognitive function and serum level of BDNF. CONCLUSION: There was an association between vitamin D on serum BDNF and on cognitive decline in older adults. Moreover, BDNF did not have an effect on cognitive decline, so BDNF was not a mediator of the vitamin D effect on cognitive decline.Universidade de São Paulo. Faculdade de Saúde Pública2022-12-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/xmlhttps://www.revistas.usp.br/rsp/article/view/20576110.11606/s1518-8787.2022056004134Revista de Saúde Pública; Vol. 56 (2022); 109Revista de Saúde Pública; Vol. 56 (2022); 109Revista de Saúde Pública; v. 56 (2022); 1091518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/rsp/article/view/205761/189284https://www.revistas.usp.br/rsp/article/view/205761/189283Copyright (c) 2022 Anna Quialheiro, Eleonora d´Orsi, Júlia Dubois Moreira, André Junqueira Xavier, Marco Aurélio Pereshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessQuialheiro, Annad´Orsi, EleonoraMoreira, Júlia DuboisXavier, André JunqueiraPeres, Marco Aurélio2022-12-13T21:17:13Zoai:revistas.usp.br:article/205761Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2022-12-13T21:17:13Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
The association between vitamin D and BDNF on cognition in older adults in Southern Brazil |
title |
The association between vitamin D and BDNF on cognition in older adults in Southern Brazil |
spellingShingle |
The association between vitamin D and BDNF on cognition in older adults in Southern Brazil Quialheiro, Anna Aged Cognition Vitamin D Brain-Derived Neurotrophic Factor |
title_short |
The association between vitamin D and BDNF on cognition in older adults in Southern Brazil |
title_full |
The association between vitamin D and BDNF on cognition in older adults in Southern Brazil |
title_fullStr |
The association between vitamin D and BDNF on cognition in older adults in Southern Brazil |
title_full_unstemmed |
The association between vitamin D and BDNF on cognition in older adults in Southern Brazil |
title_sort |
The association between vitamin D and BDNF on cognition in older adults in Southern Brazil |
author |
Quialheiro, Anna |
author_facet |
Quialheiro, Anna d´Orsi, Eleonora Moreira, Júlia Dubois Xavier, André Junqueira Peres, Marco Aurélio |
author_role |
author |
author2 |
d´Orsi, Eleonora Moreira, Júlia Dubois Xavier, André Junqueira Peres, Marco Aurélio |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Quialheiro, Anna d´Orsi, Eleonora Moreira, Júlia Dubois Xavier, André Junqueira Peres, Marco Aurélio |
dc.subject.por.fl_str_mv |
Aged Cognition Vitamin D Brain-Derived Neurotrophic Factor |
topic |
Aged Cognition Vitamin D Brain-Derived Neurotrophic Factor |
description |
OBJECTIVE: To estimate the association between vitamin D and the cognitive decline of older adults and evaluate whether this association is mediated by brain-derived neurotrophic factor (BDNF) serum concentration. METHODS: Cross-sectional study nested in a population-based cohort. Of the 604 participants in the complementary examination of the EpiFloripa Study, 576 older adults (60 years or older) were eligible for the study. The outcome is cognitive decline evaluated by the Mini-Mental State Examination, the exposure is vitamin D, and BDNF is the mediator. The control variables are age, sex, per capita family income, and educational level. The direct effect of vitamin D and BDNF on cognitive decline and the indirect effect mediated by BDNF was evaluated using path analysis, with the estimation of standardized coefficients. RESULTS: Among the participants, we observed a direct and positive effect of vitamin D on cognitive function (Coef: 0.06; 95%CI 0.02 to 0.11; p < 0.001) and serum BDNF concentration (Coef: 21.55; 95%CI 9.92 to 33.17; p = 0.002), i.e., the higher the vitamin D, the higher the cognitive function and serum level of BDNF. CONCLUSION: There was an association between vitamin D on serum BDNF and on cognitive decline in older adults. Moreover, BDNF did not have an effect on cognitive decline, so BDNF was not a mediator of the vitamin D effect on cognitive decline. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-13 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/205761 10.11606/s1518-8787.2022056004134 |
url |
https://www.revistas.usp.br/rsp/article/view/205761 |
identifier_str_mv |
10.11606/s1518-8787.2022056004134 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/205761/189284 https://www.revistas.usp.br/rsp/article/view/205761/189283 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/xml |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
dc.source.none.fl_str_mv |
Revista de Saúde Pública; Vol. 56 (2022); 109 Revista de Saúde Pública; Vol. 56 (2022); 109 Revista de Saúde Pública; v. 56 (2022); 109 1518-8787 0034-8910 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
_version_ |
1800221803345346560 |