Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | https://www.revistas.usp.br/rsp/article/view/195077 |
Resumo: | OBJECTIVE To investigated the effect of oropharyngeal colostrum immunotherapy in reducing the time required for very low birth weight preterm newborns (VLBW-PTNB: < 1,500g and < 37 weeks) to achieve full enteral nutrition. METHODS Literature search was conducted using four databases, including gray literature, with additional manual search of the references of selected articles. Eligibility criteria consisted of randomized clinical trials, without restriction regarding the date or language of the publication. Two independent reviewers performed the article selection and data extraction. The random-effects meta-analysis used a non-standard technique to assess the mean difference in days to achieve full enteral nutrition, carried out by the Stata 15 statistic program. RESULTS The systematic review comprised 10 studies, and five were selected for meta-analysis, with a population of 764 VLBW-PTNB and gestational age of birth between 25 and 32 weeks. The studies were conducted between 2011 and 2018 in North America, Asia and Africa, with only one conducted in South America. Altogether, they reported the number of days it took 708 VLBW-PTNB to achieve full enteral nutrition, with newborns treated with immunotherapy showing a shorter time in only three studies. Meta-analysis showed a mean difference of -4.26 days, (95% CI -7.44; -1.08d), with high heterogeneity (I2 = 83.1%). CONCLUSION The use of oropharyngeal colostrum immunotherapy can reduce the time for VLBW-PTNB to achieve full nutrition when compared to those who used a placebo or received routine care. |
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Revista de Saúde Pública |
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Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysisInfant, Very Low Birth WeightInfant, PrematureImmunotherapyColostrumSystematic ReviewOBJECTIVE To investigated the effect of oropharyngeal colostrum immunotherapy in reducing the time required for very low birth weight preterm newborns (VLBW-PTNB: < 1,500g and < 37 weeks) to achieve full enteral nutrition. METHODS Literature search was conducted using four databases, including gray literature, with additional manual search of the references of selected articles. Eligibility criteria consisted of randomized clinical trials, without restriction regarding the date or language of the publication. Two independent reviewers performed the article selection and data extraction. The random-effects meta-analysis used a non-standard technique to assess the mean difference in days to achieve full enteral nutrition, carried out by the Stata 15 statistic program. RESULTS The systematic review comprised 10 studies, and five were selected for meta-analysis, with a population of 764 VLBW-PTNB and gestational age of birth between 25 and 32 weeks. The studies were conducted between 2011 and 2018 in North America, Asia and Africa, with only one conducted in South America. Altogether, they reported the number of days it took 708 VLBW-PTNB to achieve full enteral nutrition, with newborns treated with immunotherapy showing a shorter time in only three studies. Meta-analysis showed a mean difference of -4.26 days, (95% CI -7.44; -1.08d), with high heterogeneity (I2 = 83.1%). CONCLUSION The use of oropharyngeal colostrum immunotherapy can reduce the time for VLBW-PTNB to achieve full nutrition when compared to those who used a placebo or received routine care.IUniversidade de São Paulo. Faculdade de Saúde Pública2021-12-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/xmlhttps://www.revistas.usp.br/rsp/article/view/19507710.11606/s1518-8787.2021055003051Revista de Saúde Pública; Vol. 55 (2021); 59Revista de Saúde Pública; Vol. 55 (2021); 59Revista de Saúde Pública; v. 55 (2021); 591518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/rsp/article/view/195077/180350https://www.revistas.usp.br/rsp/article/view/195077/180349Copyright (c) 2021 Michelle de Santana Xavier Ramos, Camilla da Cruz Martins, Elivan Silva Souza, Graciete Oliveira Vieira, Isaac Suzart Gomes-Filho, Ana Claudia Morais Godoy Figueiredo, Maurício Gomes Pereira, Simone Seixas da Cruzhttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRamos, Michelle de Santana XavierMartins, Camilla da Cruz Souza, Elivan SilvaVieira, Graciete Oliveira Gomes-Filho, Isaac SuzartFigueiredo, Ana Claudia Morais Godoy Pereira, Maurício GomesCruz, Simone Seixas da2022-02-18T14:17:43Zoai:revistas.usp.br:article/195077Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2022-02-18T14:17:43Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis |
title |
Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis |
spellingShingle |
Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis Ramos, Michelle de Santana Xavier Infant, Very Low Birth Weight Infant, Premature Immunotherapy Colostrum Systematic Review |
title_short |
Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis |
title_full |
Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis |
title_fullStr |
Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis |
title_full_unstemmed |
Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis |
title_sort |
Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis |
author |
Ramos, Michelle de Santana Xavier |
author_facet |
Ramos, Michelle de Santana Xavier Martins, Camilla da Cruz Souza, Elivan Silva Vieira, Graciete Oliveira Gomes-Filho, Isaac Suzart Figueiredo, Ana Claudia Morais Godoy Pereira, Maurício Gomes Cruz, Simone Seixas da |
author_role |
author |
author2 |
Martins, Camilla da Cruz Souza, Elivan Silva Vieira, Graciete Oliveira Gomes-Filho, Isaac Suzart Figueiredo, Ana Claudia Morais Godoy Pereira, Maurício Gomes Cruz, Simone Seixas da |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Ramos, Michelle de Santana Xavier Martins, Camilla da Cruz Souza, Elivan Silva Vieira, Graciete Oliveira Gomes-Filho, Isaac Suzart Figueiredo, Ana Claudia Morais Godoy Pereira, Maurício Gomes Cruz, Simone Seixas da |
dc.subject.por.fl_str_mv |
Infant, Very Low Birth Weight Infant, Premature Immunotherapy Colostrum Systematic Review |
topic |
Infant, Very Low Birth Weight Infant, Premature Immunotherapy Colostrum Systematic Review |
description |
OBJECTIVE To investigated the effect of oropharyngeal colostrum immunotherapy in reducing the time required for very low birth weight preterm newborns (VLBW-PTNB: < 1,500g and < 37 weeks) to achieve full enteral nutrition. METHODS Literature search was conducted using four databases, including gray literature, with additional manual search of the references of selected articles. Eligibility criteria consisted of randomized clinical trials, without restriction regarding the date or language of the publication. Two independent reviewers performed the article selection and data extraction. The random-effects meta-analysis used a non-standard technique to assess the mean difference in days to achieve full enteral nutrition, carried out by the Stata 15 statistic program. RESULTS The systematic review comprised 10 studies, and five were selected for meta-analysis, with a population of 764 VLBW-PTNB and gestational age of birth between 25 and 32 weeks. The studies were conducted between 2011 and 2018 in North America, Asia and Africa, with only one conducted in South America. Altogether, they reported the number of days it took 708 VLBW-PTNB to achieve full enteral nutrition, with newborns treated with immunotherapy showing a shorter time in only three studies. Meta-analysis showed a mean difference of -4.26 days, (95% CI -7.44; -1.08d), with high heterogeneity (I2 = 83.1%). CONCLUSION The use of oropharyngeal colostrum immunotherapy can reduce the time for VLBW-PTNB to achieve full nutrition when compared to those who used a placebo or received routine care. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/195077 10.11606/s1518-8787.2021055003051 |
url |
https://www.revistas.usp.br/rsp/article/view/195077 |
identifier_str_mv |
10.11606/s1518-8787.2021055003051 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/195077/180350 https://www.revistas.usp.br/rsp/article/view/195077/180349 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/xml |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
dc.source.none.fl_str_mv |
Revista de Saúde Pública; Vol. 55 (2021); 59 Revista de Saúde Pública; Vol. 55 (2021); 59 Revista de Saúde Pública; v. 55 (2021); 59 1518-8787 0034-8910 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
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1800221802604003328 |