Suspected acute toxoplasmosis in pregnant women
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | https://www.revistas.usp.br/rsp/article/view/32190 |
Resumo: | OBJECTIVE: To determine the prevalence of reagent serology for suspected acute toxoplasmosis in pregnant women and to describe clinical, laboratory and therapeutic profiles of mothers and their children. METHODS: A retrospective study was conducted with IgM-anti-Toxoplasma gondii-reagent pregnant women and their children who attended the public health system in the state of Paraná, Southern Brazil, from January 2001 to December 2003. Information were obtained from clinical, laboratory (ELISA IgM/IgG) and ultrasonographic data and from interviews with the mothers. To test the homogeneity of the IgM indices in relation to the treatment used, the Pearson's Chi-square test was applied. Comparisons were considered significant at a 5% level. RESULTS: Two hundred and ninety (1.0%) cases of suspected IgM-reagent infection were documented, with a prevalence of 10.7 IgM-reagent women per 1,000 births. Prenatal care started within the first 12 weeks for 214/290; 146/204 were asymptomatic. Frequent complaints included headaches, visual disturbance and myalgia. Ultrasonography revealed abnormalities in 13 of 204 pregnancies. Chemoprophylaxis was administered to 112/227; a single ELISA test supported most decisions to begin treatment. Pregnant women with IgM indices =2.000 tended to be treated more often. Among exposed children, 44/208 were serologically followed up and all were IgG-reagent, and three IgM-reagent cases showed clinical symptoms. CONCLUSIONS: The existence of pregnant women with laboratorially suspected acute toxoplasmosis who were not properly followed up, and of fetuses that were not adequately monitored, shows that basic aspects of the prenatal care are not being systematically observed. There is need of implementing a surveillance system of pregnant women and their children exposed to T. gondii. |
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Suspected acute toxoplasmosis in pregnant women Suspeita de toxoplasmose aguda em gestantes GestantesToxoplasmose^i2^sepidemioloToxoplasmose congênita^i2^sprevenção e contrToxoplasmose congênitadiagnósticoCuidado pré-natalEstudos soroepidemiológicosServiços de vigilância epidemiológicaPregnant womenToxoplasmosisepidemiologyToxoplasmosis^i1^scongenitalprevention & contToxoplasmosis^i1^scongeniToxoplasmosis^i1^sdiagnoPrenatal careSeroepidemiological studiesEpidemiological surveillance services OBJECTIVE: To determine the prevalence of reagent serology for suspected acute toxoplasmosis in pregnant women and to describe clinical, laboratory and therapeutic profiles of mothers and their children. METHODS: A retrospective study was conducted with IgM-anti-Toxoplasma gondii-reagent pregnant women and their children who attended the public health system in the state of Paraná, Southern Brazil, from January 2001 to December 2003. Information were obtained from clinical, laboratory (ELISA IgM/IgG) and ultrasonographic data and from interviews with the mothers. To test the homogeneity of the IgM indices in relation to the treatment used, the Pearson's Chi-square test was applied. Comparisons were considered significant at a 5% level. RESULTS: Two hundred and ninety (1.0%) cases of suspected IgM-reagent infection were documented, with a prevalence of 10.7 IgM-reagent women per 1,000 births. Prenatal care started within the first 12 weeks for 214/290; 146/204 were asymptomatic. Frequent complaints included headaches, visual disturbance and myalgia. Ultrasonography revealed abnormalities in 13 of 204 pregnancies. Chemoprophylaxis was administered to 112/227; a single ELISA test supported most decisions to begin treatment. Pregnant women with IgM indices =2.000 tended to be treated more often. Among exposed children, 44/208 were serologically followed up and all were IgG-reagent, and three IgM-reagent cases showed clinical symptoms. CONCLUSIONS: The existence of pregnant women with laboratorially suspected acute toxoplasmosis who were not properly followed up, and of fetuses that were not adequately monitored, shows that basic aspects of the prenatal care are not being systematically observed. There is need of implementing a surveillance system of pregnant women and their children exposed to T. gondii. OBJETIVO: Determinar a prevalência de gestantes com sorologia reagente suspeita de toxoplasmose aguda e descrever as variáveis maternas e do concepto relacionadas ao perfil clínico, laboratorial e terapêutico. MÉTODOS: Estudo retrospectivo com gestantes IgM anti-Toxoplasma gondii reagentes e conceptos atendidos em serviço público de saúde do Paraná, de janeiro/2001-dezembro/2003. Foram obtidas informações a partir de dados dos registros clínicos, laboratoriais (ELISA IgM/IgG), ultrassonográficos e de entrevista materna. Para testar a homogeneidade dos indices de IgM em relação ao tratamento usado, aplicou-se o qui-quadrado de Pearson. O nível de significância adotado foi de 5%. RESULTADOS: Ocorreram 290 casos (1,0%) IgM reagentes, evidenciando prevalência de 10,7 gestantes com sorologia reagente a cada 1.000 nascimentos. Duzentos e quatorze de 290 gestantes iniciaram o pré-natal até a 12ª semana de gestação; 146/204 foram assintomáticas; cefaléia, distúrbios visuais e mialgia foram queixas freqüentes; 13/204 gestantes apresentaram anormalidades ao ultrassom; 112/227 gestantes receberam quimioprofilaxia; um único teste ELISA apoiou a maioria das tomadas de decisão para a quimioprofilaxia. Houve tendência em tratar gestantes com índices de IgM=2.000. Dentre as crianças expostas, 44/208 tiveram algum acompanhamento sorológico, das quais todas foram IgG reagentes e três casos IgM reagentes apresentaram manifestações clínicas. CONCLUSÕES: A existência de gestantes com suspeita laboratorial de toxoplasmose aguda não devidamente investigada e de conceptos sem monitoração adequada evidenciam que aspectos fundamentais da assistência pré-natal não estão sendo sistematicamente observados. Aponta-se a necessidade de implementar o sistema de vigilância para gestantes e crianças expostas ao T. gondii. Universidade de São Paulo. Faculdade de Saúde Pública2007-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/3219010.1590/S0034-89102007000100005Revista de Saúde Pública; Vol. 41 No. 1 (2007); 27-34 Revista de Saúde Pública; Vol. 41 Núm. 1 (2007); 27-34 Revista de Saúde Pública; v. 41 n. 1 (2007); 27-34 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/rsp/article/view/32190/34292Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessCastilho-Pelloso, Marcela PeresFalavigna, Dina Lúcia MoraisFalavigna-Guilherme, Ana Lúcia2012-07-09T00:27:52Zoai:revistas.usp.br:article/32190Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-07-09T00:27:52Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Suspected acute toxoplasmosis in pregnant women Suspeita de toxoplasmose aguda em gestantes |
title |
Suspected acute toxoplasmosis in pregnant women |
spellingShingle |
Suspected acute toxoplasmosis in pregnant women Castilho-Pelloso, Marcela Peres Gestantes Toxoplasmose^i2^sepidemiolo Toxoplasmose congênita^i2^sprevenção e contr Toxoplasmose congênita diagnóstico Cuidado pré-natal Estudos soroepidemiológicos Serviços de vigilância epidemiológica Pregnant women Toxoplasmosis epidemiology Toxoplasmosis^i1^scongenital prevention & cont Toxoplasmosis^i1^scongeni Toxoplasmosis^i1^sdiagno Prenatal care Seroepidemiological studies Epidemiological surveillance services |
title_short |
Suspected acute toxoplasmosis in pregnant women |
title_full |
Suspected acute toxoplasmosis in pregnant women |
title_fullStr |
Suspected acute toxoplasmosis in pregnant women |
title_full_unstemmed |
Suspected acute toxoplasmosis in pregnant women |
title_sort |
Suspected acute toxoplasmosis in pregnant women |
author |
Castilho-Pelloso, Marcela Peres |
author_facet |
Castilho-Pelloso, Marcela Peres Falavigna, Dina Lúcia Morais Falavigna-Guilherme, Ana Lúcia |
author_role |
author |
author2 |
Falavigna, Dina Lúcia Morais Falavigna-Guilherme, Ana Lúcia |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Castilho-Pelloso, Marcela Peres Falavigna, Dina Lúcia Morais Falavigna-Guilherme, Ana Lúcia |
dc.subject.por.fl_str_mv |
Gestantes Toxoplasmose^i2^sepidemiolo Toxoplasmose congênita^i2^sprevenção e contr Toxoplasmose congênita diagnóstico Cuidado pré-natal Estudos soroepidemiológicos Serviços de vigilância epidemiológica Pregnant women Toxoplasmosis epidemiology Toxoplasmosis^i1^scongenital prevention & cont Toxoplasmosis^i1^scongeni Toxoplasmosis^i1^sdiagno Prenatal care Seroepidemiological studies Epidemiological surveillance services |
topic |
Gestantes Toxoplasmose^i2^sepidemiolo Toxoplasmose congênita^i2^sprevenção e contr Toxoplasmose congênita diagnóstico Cuidado pré-natal Estudos soroepidemiológicos Serviços de vigilância epidemiológica Pregnant women Toxoplasmosis epidemiology Toxoplasmosis^i1^scongenital prevention & cont Toxoplasmosis^i1^scongeni Toxoplasmosis^i1^sdiagno Prenatal care Seroepidemiological studies Epidemiological surveillance services |
description |
OBJECTIVE: To determine the prevalence of reagent serology for suspected acute toxoplasmosis in pregnant women and to describe clinical, laboratory and therapeutic profiles of mothers and their children. METHODS: A retrospective study was conducted with IgM-anti-Toxoplasma gondii-reagent pregnant women and their children who attended the public health system in the state of Paraná, Southern Brazil, from January 2001 to December 2003. Information were obtained from clinical, laboratory (ELISA IgM/IgG) and ultrasonographic data and from interviews with the mothers. To test the homogeneity of the IgM indices in relation to the treatment used, the Pearson's Chi-square test was applied. Comparisons were considered significant at a 5% level. RESULTS: Two hundred and ninety (1.0%) cases of suspected IgM-reagent infection were documented, with a prevalence of 10.7 IgM-reagent women per 1,000 births. Prenatal care started within the first 12 weeks for 214/290; 146/204 were asymptomatic. Frequent complaints included headaches, visual disturbance and myalgia. Ultrasonography revealed abnormalities in 13 of 204 pregnancies. Chemoprophylaxis was administered to 112/227; a single ELISA test supported most decisions to begin treatment. Pregnant women with IgM indices =2.000 tended to be treated more often. Among exposed children, 44/208 were serologically followed up and all were IgG-reagent, and three IgM-reagent cases showed clinical symptoms. CONCLUSIONS: The existence of pregnant women with laboratorially suspected acute toxoplasmosis who were not properly followed up, and of fetuses that were not adequately monitored, shows that basic aspects of the prenatal care are not being systematically observed. There is need of implementing a surveillance system of pregnant women and their children exposed to T. gondii. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/32190 10.1590/S0034-89102007000100005 |
url |
https://www.revistas.usp.br/rsp/article/view/32190 |
identifier_str_mv |
10.1590/S0034-89102007000100005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/32190/34292 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Revista de Saúde Pública info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Revista de Saúde Pública |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
dc.source.none.fl_str_mv |
Revista de Saúde Pública; Vol. 41 No. 1 (2007); 27-34 Revista de Saúde Pública; Vol. 41 Núm. 1 (2007); 27-34 Revista de Saúde Pública; v. 41 n. 1 (2007); 27-34 1518-8787 0034-8910 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
_version_ |
1787713226355507200 |